ClinicalTrials.gov record
A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)
ClinicalTrials.gov ID: NCT06312137
Public ClinicalTrials.gov record NCT06312137. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 9, 2026, 8:46 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3 Randomized Open-Label Study of Adjuvant Pembrolizumab With or Without MK-2870 in Participants With Resectable Stage II to IIIB (N2) NSCLC Not Achieving pCR After Receiving Neoadjuvant Pembrolizumab With Platinum-based Doublet Chemotherapy Followed by Surgery
Study identification
- NCT ID
- NCT06312137
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Merck Sharp & Dohme LLC
- Industry
- Enrollment
- 780 participants
Conditions and interventions
Conditions
Interventions
- Carboplatin Drug
- Cisplatin Drug
- Gemcitabine Drug
- Paclitaxel Drug
- Pembrolizumab Biological
- Pemetrexed Drug
- Rescue medication Drug
- Sacituzumab tirumotecan Biological
Drug · Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 2, 2024
- Primary completion
- Feb 20, 2034
- Completion
- Oct 22, 2034
- Last update posted
- May 7, 2026
2024 – 2034
United States locations
- U.S. sites
- 48
- U.S. states
- 24
- U.S. cities
- 42
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| UAMS Winthrop P. Rockefeller Cancer Institute ( Site 0060) | Little Rock | Arkansas | 72205 | Recruiting |
| Highlands Oncology Group-Research Department ( Site 0062) | Springdale | Arkansas | 72762 | Recruiting |
| Beverly Hills Cancer Center ( Site 0070) | Beverly Hills | California | 90211 | Recruiting |
| The Angeles Clinic and Research Institute ( Site 0040) | Los Angeles | California | 90025 | Recruiting |
| The Angeles Clinic and Research Institute- A Cedars-Sinai Affiliate ( Site 0079) | Los Angeles | California | 90025 | Recruiting |
| UCLA Clinical & Translational Research Center (CTRC) ( Site 0033) | Los Angeles | California | 90095 | Recruiting |
| Hoag Memorial Hospital Presbyterian ( Site 0096) | Newport Beach | California | 92663 | Recruiting |
| San Francisco Oncology Associates ( Site 0066) | San Francisco | California | 94115 | Recruiting |
| Stamford Hospital ( Site 0083) | Stamford | Connecticut | 06902 | Recruiting |
| Mayo Clinic in Florida ( Site 0014) | Jacksonville | Florida | 32224 | Recruiting |
| Mount Sinai Cancer Center ( Site 0038) | Miami Beach | Florida | 33140 | Recruiting |
| Mid Florida Hematology and Oncology Center ( Site 0018) | Orange City | Florida | 32763 | Recruiting |
| Emory University School of Medicine-Phase I ( Site 0056) | Atlanta | Georgia | 30322 | Recruiting |
| Northside Hospital ( Site 0055) | Atlanta | Georgia | 30342 | Recruiting |
| Centricity Research Columbus Cancer Center ( Site 0005) | Columbus | Georgia | 31904 | Completed |
| Southeastern Regional Medical Center ( Site 0065) | Newnan | Georgia | 30265 | Recruiting |
| Lewis Cancer and Research Pavilion ( Site 0063) | Savannah | Georgia | 31405 | Recruiting |
| Archbold Cancer Center ( Site 0071) | Thomasville | Georgia | 31792 | Recruiting |
| Edward-Elmhurst Healthcare, Elmhurst Hospital-Nancy W. Knowles Cancer Center ( Site 0017) | Elmhurst | Illinois | 60126 | Completed |
| Accellacare of Duly ( Site 4005) | Lisle | Illinois | 60532 | Recruiting |
| Edward-Elmhurst Healthcare, Edward Hospital-Edward Cancer Center ( Site 0078) | Naperville | Illinois | 60540 | Completed |
| Parkview Research Center at Parkview Regional Medical Center ( Site 0089) | Fort Wayne | Indiana | 46845 | Recruiting |
| Indiana University Health Arnett Cancer Center ( Site 0076) | Lafayette | Indiana | 47904 | Recruiting |
| Saint Elizabeth Medical Center Edgewood-Cancer Care Center ( Site 0061) | Edgewood | Kentucky | 41017 | Recruiting |
| LSU Health Baton Rouge North Clinic ( Site 4003) | Baton Rouge | Louisiana | 70805 | Recruiting |
| Our Lady of the Lake Physician Group-Medical Oncology ( Site 0080) | Baton Rouge | Louisiana | 70808 | Recruiting |
| New England Cancer Specialists ( Site 0095) | Westbrook | Maine | 04092 | Recruiting |
| Allina Health Cancer Institute - Abbott Northwestern Hospital ( Site 0027) | Minneapolis | Minnesota | 55407 | Recruiting |
| Mayo Clinic - Rochester ( Site 0073) | Rochester | Minnesota | 55905 | Recruiting |
| Mercy South - David M Sindelar Cancer Center ( Site 0098) | St Louis | Missouri | 63128 | Recruiting |
| Mercy Research - David C. Pratt Cancer Center ( Site 0006) | St Louis | Missouri | 63141 | Recruiting |
| Renown Regional Medical Center-Renown Health Medical Oncology ( Site 0037) | Reno | Nevada | 89502 | Recruiting |
| Atlantic Health Morristown Medical Center ( Site 0077) | Morristown | New Jersey | 07960 | Recruiting |
| Cayuga Medical Center ( Site 0086) | Ithaca | New York | 14850 | Recruiting |
| Stony Brook University-Cancer Center ( Site 0054) | Stony Brook | New York | 11794 | Recruiting |
| White Plains Hospital ( Site 0091) | White Plains | New York | 10601 | Recruiting |
| Sanford Fargo Medical Center-Roger Maris Cancer Center ( Site 0057) | Fargo | North Dakota | 58102 | Recruiting |
| Hightower Clinical, LLC ( Site 0084) | Oklahoma City | Oklahoma | 73102 | Recruiting |
| Oregon Health and Science University ( Site 0052) | Portland | Oregon | 97239 | Recruiting |
| Penn State Milton S. Hershey Medical Center-Penn State Cancer Institute ( Site 0059) | Hershey | Pennsylvania | 17033 | Recruiting |
| Lancaster General Hospital - Ann B Barshinger Cancer Institute ( Site 0068) | Lancaster | Pennsylvania | 17601 | Recruiting |
| Saint Joseph's Candler Health System ( Site 4010) | Bluffton | South Carolina | 29910 | Recruiting |
| Medical University of South Carolina-Hollings Cancer Center ( Site 0045) | Charleston | South Carolina | 29425 | Recruiting |
| Sanford Cancer Center ( Site 0053) | Sioux Falls | South Dakota | 57104 | Recruiting |
| Avera Cancer Institute- Research ( Site 0090) | Sioux Falls | South Dakota | 57105 | Recruiting |
| University of Tennessee Medical Center Knoxville ( Site 0082) | Knoxville | Tennessee | 37920 | Recruiting |
| Millennium Research & Clinical Development ( Site 0039) | Houston | Texas | 77090 | Completed |
| Huntsman Cancer Institute ( Site 0042) | Salt Lake City | Utah | 84112-5500 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 212 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06312137, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 7, 2026 · Synced May 9, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06312137 live on ClinicalTrials.gov.