ClinicalTrials.gov record
A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)
ClinicalTrials.gov ID: NCT06312176
Public ClinicalTrials.gov record NCT06312176. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 19, 2026, 8:53 PM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
An Open-label, Randomized Phase 3 Study of MK-2870 as a Single Agent and in Combination With Pembrolizumab Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer
Study identification
- NCT ID
- NCT06312176
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Merck Sharp & Dohme LLC
- Industry
- Enrollment
- 1,200 participants
Conditions and interventions
Conditions
Interventions
- Capecitabine Drug
- Liposomal doxorubicin Drug
- Nab-paclitaxel Drug
- Paclitaxel Drug
- Pembrolizumab Biological
- Sacituzumab tirumotecan Drug
Drug · Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 13, 2024
- Primary completion
- Jul 10, 2027
- Completion
- Apr 11, 2031
- Last update posted
- May 14, 2026
2024 – 2031
United States locations
- U.S. sites
- 46
- U.S. states
- 21
- U.S. cities
- 41
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Ironwood Cancer & Research Centers ( Site 0066) | Chandler | Arizona | 85224 | Recruiting |
| Banner MD Anderson Cancer Center-Oncology ( Site 0004) | Gilbert | Arizona | 85234 | Recruiting |
| Providence Medical Foundation-Oncology ( Site 0020) | Fullerton | California | 92835 | Recruiting |
| Moores Cancer Center ( Site 0059) | La Jolla | California | 92093-0698 | Active, not recruiting |
| Cancer and Blood Specialty Clinic ( Site 0001) | Los Alamitos | California | 90720 | Recruiting |
| University of Colorado Anschutz Medical Campus ( Site 0061) | Aurora | Colorado | 80045 | Recruiting |
| UCHealth Cherry Creek Medical Center ( Site 0094) | Denver | Colorado | 80206 | Recruiting |
| University of Colorado Health - Highlands Ranch Hospital ( Site 0095) | Highlands Ranch | Colorado | 80129 | Recruiting |
| Yale Cancer Center ( Site 0060) | New Haven | Connecticut | 06510 | Recruiting |
| Stamford Hospital ( Site 0049) | Stamford | Connecticut | 06902 | Recruiting |
| AdventHealth Altamonte Springs ( Site 0021) | Altamonte Springs | Florida | 32701 | Recruiting |
| University of Florida College of Medicine ( Site 0063) | Gainesville | Florida | 32610 | Recruiting |
| Orlando Health Cancer Institute ( Site 0011) | Orlando | Florida | 32806 | Recruiting |
| Archbold Memorial Hospital-Lewis Hall Singletary Oncology Center ( Site 0032) | Thomasville | Georgia | 31792 | Recruiting |
| Rush University Medical Center ( Site 0079) | Chicago | Illinois | 60607 | Recruiting |
| University of Chicago Medical Center ( Site 0067) | Chicago | Illinois | 60637 | Recruiting |
| Saint Elizabeth Medical Center Edgewood-Cancer Care Center ( Site 0053) | Edgewood | Kentucky | 41017 | Recruiting |
| Mary Bird Perkins Cancer Center-Breast & GYN Pavilion ( Site 0042) | Baton Rouge | Louisiana | 70817 | Recruiting |
| Greenebaum Comprehensive Cancer Center ( Site 0036) | Baltimore | Maryland | 21201 | Recruiting |
| Mercy Medical Center - Baltimore-Medical Oncology and Hematology ( Site 0028) | Baltimore | Maryland | 21202 | Completed |
| Holy Cross Hospital ( Site 0073) | Silver Spring | Maryland | 20910 | Recruiting |
| Dana-Farber Cancer Institute-Breast Oncology Center ( Site 0037) | Boston | Massachusetts | 02215 | Recruiting |
| Henry Ford Health ( Site 0002) | Detroit | Michigan | 48202 | Recruiting |
| Saint Luke's Cancer Institute ( Site 0027) | Kansas City | Missouri | 64111 | Recruiting |
| Washington University School of Medicine ( Site 0076) | St Louis | Missouri | 63110 | Recruiting |
| NYU Langone Health - Brooklyn ( Site 0089) | Brooklyn | New York | 11220 | Recruiting |
| NYU Langone Hospital - Long Island ( Site 0090) | Mineola | New York | 11501 | Recruiting |
| Laura and Isaac Perlmutter Cancer Center-Hematology and Oncology ( Site 0068) | New York | New York | 10016 | Recruiting |
| Hematology Oncology Associates of Rockland ( Site 0054) | Nyack | New York | 10960 | Recruiting |
| Stony Brook University-Cancer Center ( Site 0034) | Stony Brook | New York | 11794 | Recruiting |
| Levine Cancer Institute ( Site 0014) | Charlotte | North Carolina | 28204 | Recruiting |
| Zangmeister Cancer Center ( Site 7000) | Columbus | Ohio | 43219 | Recruiting |
| Providence Portland Medical Center ( Site 0044) | Portland | Oregon | 97213 | Recruiting |
| Providence St. Vincent Medical Center ( Site 0081) | Portland | Oregon | 97225 | Recruiting |
| Thomas Jefferson University - Clinical Research Institute ( Site 0056) | Philadelphia | Pennsylvania | 19107 | Recruiting |
| Texas Oncology-Dallas Presbyterian Hospital ( Site 8000) | Dallas | Texas | 75231 | Recruiting |
| Parkland Health and Hospital System ( Site 0069) | Dallas | Texas | 75235 | Recruiting |
| UT Southwestern Medical Center ( Site 0050) | Dallas | Texas | 75390 | Recruiting |
| The Center for Cancer and Blood Disorders ( Site 0041) | Fort Worth | Texas | 76104 | Recruiting |
| Texas Oncology - San Antonio ( Site 8002) | San Antonio | Texas | 78240 | Recruiting |
| The University of Texas Health Science Center at Tyler dba UT Health East Texas HOPE Cancer Center ( Site 0057) | Tyler | Texas | 75701 | Recruiting |
| Inova Schar Cancer Institute ( Site 0025) | Fairfax | Virginia | 22031 | Recruiting |
| Bon Secours St. Francis Medical Center-Oncology Research ( Site 0015) | Midlothian | Virginia | 23114 | Recruiting |
| VCU Health Adult Outpatient Pavillion ( Site 0070) | Richmond | Virginia | 23219 | Recruiting |
| Oncology and Hematology Associates of Southwest Virginia (BRCC) ( Site 8001) | Roanoke | Virginia | 24014 | Recruiting |
| University Hospital and UW Health Clinics-Carbone Cancer Center ( Site 0040) | Madison | Wisconsin | 53792 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 212 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06312176, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 14, 2026 · Synced May 19, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06312176 live on ClinicalTrials.gov.