A Study Evaluating the Efficacy and Safety of Pegozafermin in Participants With MASH and Fibrosis (ENLIGHTEN-Fibrosis)

ClinicalTrials.gov ID: NCT06318169

Public ClinicalTrials.gov record NCT06318169. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 6, 2026, 8:58 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3 Study to Evaluate the Efficacy and Safety of Pegozafermin in Subjects With Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Fibrosis

Study identification

NCT ID: NCT06318169
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: 89bio, Inc.; Industry
Enrollment: 1,350 participants

Conditions and interventions

Conditions

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASH) / Nonalcoholic Steatohepatitis (NASH) With Fibrosis

Interventions

Pegozafermin Biological
Placebo Other

Biological · Other

Eligibility (public fields only)

Age range: 18 Years to 80 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Mar 12, 2024
Primary completion: Jan 31, 2029
Completion: Jan 31, 2029
Last update posted: May 4, 2026

2024 – 2029

United States locations

U.S. sites: 135
U.S. states: 31
U.S. cities: 119

Facility	City	State	ZIP	Site status
89bio Clinical Study Site	Birmingham	Alabama	35209	Recruiting
89bio Clinical Study Site	Chandler	Arizona	85224	Recruiting
89bio Clinical Study Site	Flagstaff	Arizona	86001	Recruiting
89bio Clinical Study Site	Glendale	Arizona	85036	Recruiting
89bio Clinical Study Site	Tucson	Arizona	85712	Recruiting
89bio Clinical Study Site	Conway	Arkansas	72032	Terminated
89bio Clinical Study Site	Little Rock	Arkansas	72211-3859	Recruiting
89bio Clinical Study Site	North Little Rock	Arkansas	72117	Recruiting
89bio Clinical Study Site	Canoga Park	California	91604	Recruiting
89bio Clinical Study Site	Coronado	California	92118	Recruiting
89bio Clinical Study Site	Fountain Valley	California	92708	Recruiting
89bio Clinical Study Site	Fresno	California	93720	Recruiting
89bio Clinical Study Site	Gardena	California	90247	Recruiting
89bio Clinical Study Site	Huntington Park	California	90255	Terminated
89bio Clinical Study Site	Inglewood	California	90301	Recruiting
89bio Clinical Study Site	La Jolla	California	92037	Recruiting
89bio Clinical Study Site	Lancaster	California	93534	Recruiting
89bio Clinical Study Site	Long Beach	California	90815	Recruiting
89bio Clinical Study Site	Los Angeles	California	90048	Recruiting
89bio Clinical Study Site	Montclair	California	91763	Recruiting
89bio Clinical Study Site	Orange	California	92868	Recruiting
89bio Clinical Study Site	Panorama City	California	91402	Recruiting
89bio Clinical Study Site	Pasadena	California	91105	Recruiting
89bio Clinical Study Site	Poway	California	92064	Recruiting
89bio Clinical Study Site	Rialto	California	92377	Recruiting
89bio Clinical Study Site	Santa Ana	California	92704-5763	Terminated
89bio Clinical Study Site	Stanford	California	94305	Recruiting
89bio Clinical Study Site	Victorville	California	92395	Recruiting
89bio Clinical Study Site	Colorado Springs	Colorado	80923	Recruiting
89bio Clinical Study Site	Littleton	Colorado	80120	Recruiting
89bio Clinical Study Site	Brandon	Florida	33511	Recruiting
89bio Clinical Study Site	Clermont	Florida	34711	Recruiting
89bio Clinical Study Site	Fort Myers	Florida	33912	Recruiting
89bio Clinical Study Site	Hialeah Gardens	Florida	33016	Recruiting
89bio Clinical Study Site	Homestead	Florida	33030	Recruiting
89bio Clinical Study Site	Jacksonville	Florida	32256	Recruiting
89bio Clinical Study Site	Jupiter	Florida	33458	Recruiting
89bio Clinical Study Site	Lady Lake	Florida	32159-6831	Recruiting
89bio Clinical Study Site	Lady Lake	Florida	32159-8986	Terminated
89bio Clinical Study Site	Lakewood Rch	Florida	34211	Recruiting
89bio Clinical Study Site	Lehigh Acres	Florida	33936	Recruiting
89bio Clinical Study Site	Maitland	Florida	32751-7258	Recruiting
89bio Clinical Study Site	Maitland	Florida	32751-7497	Recruiting
89bio Clinical Study Site	New Port Richey	Florida	34653	Recruiting
89bio Clinical Study Site	Ocala	Florida	34471	Recruiting
89bio Clinical Study Site	Ocoee	Florida	34761	Recruiting
89bio Clinical Study Site	Sarasota	Florida	34240	Recruiting
89bio Clinical Study Site	Winter Park	Florida	32789	Recruiting
89bio Clinical Study Site	Athens	Georgia	30607	Recruiting
89bio Clinical Study Site	Dalton	Georgia	30720	Recruiting
89bio Clinical Study Site	Chicago	Illinois	60611	Recruiting
89bio Clinical Study Site	Hammond	Indiana	46324	Recruiting
89bio Clinical Study Site	New Albany	Indiana	47150	Recruiting
89bio Clinical Study Site	South Bend	Indiana	46635	Recruiting
89bio Clinical Study Site	Iowa City	Iowa	52242	Recruiting
89bio Clinical Study Site	Topeka	Kansas	66606	Recruiting
89bio Clinical Study Site	Covington	Louisiana	70433	Recruiting
89bio Clinical Study Site	Houma	Louisiana	70360	Recruiting
89bio Clinical Study Site	Lake Charles	Louisiana	70605	Recruiting
89bio Clinical Study Site	Marrero	Louisiana	70072	Recruiting
89bio Clinical Study Site	New Orleans	Louisiana	70115	Recruiting
89bio Clinical Study Site	West Monroe	Louisiana	71291	Recruiting
89bio Clinical Study Site	Baltimore	Maryland	21202	Recruiting
89bio Clinical Study Site	Glen Burnie	Maryland	21061	Recruiting
89bio Clinical Study Site	Greenbelt	Maryland	20770	Recruiting
89bio Clinical Study Site	Burlington	Massachusetts	01805	Recruiting
89bio Clinical Study Site	Chesterfield	Michigan	48047	Recruiting
89bio Clinical Study Site	Wyoming	Michigan	49519	Recruiting
89bio Clinical Study Site	Ypsilanti	Michigan	48197	Recruiting
89bio Clinical Study Site	Rochester	Minnesota	55905	Recruiting
89bio Clinical Study Site	Flowood	Mississippi	39232	Recruiting
89bio Clinical Study Site	St Louis	Missouri	63123	Recruiting
89bio Clinical Study Site	Las Vegas	Nevada	89106	Recruiting
89bio Clinical Study Site	Florham Park	New Jersey	07932	Terminated
89bio Clinical Study Site	Freehold	New Jersey	07728	Recruiting
89bio Clinical Study Site	Warren Township	New Jersey	07059	Recruiting
89bio Clinical Study Site	Albuquerque	New Mexico	87109	Recruiting
89bio Clinical Study Site	Carmel	New York	10512	Recruiting
89bio Clinical Study Site	New York	New York	10021	Recruiting
89bio Clinical Study Site	New York	New York	10033	Terminated
89bio Clinical Study Site	Charlotte	North Carolina	28207	Recruiting
89bio Clinical Study Site	Durham	North Carolina	27710	Recruiting
89bio Clinical Study Site	Fayetteville	North Carolina	28304	Recruiting
89bio Clinical Study Site	Morehead City	North Carolina	28557	Recruiting
89bio Clinical Study Site	Raleigh	North Carolina	27612	Recruiting
89bio Clinical Study Site	Winston-Salem	North Carolina	27103	Recruiting
89bio Clinical Study Site	Akron	Ohio	44320	Recruiting
89bio Clinical Study Site	Cleveland	Ohio	44106	Recruiting
89bio Clinical Study Site	Dayton	Ohio	45414	Recruiting
89bio Clinical Study Site	Liberty Township	Ohio	45044	Recruiting
89bio Clinical Study Site	Lima	Ohio	45801	Recruiting
89bio Clinical Study Site	Springboro	Ohio	45066	Recruiting
89bio Clinical Study Site	Westlake	Ohio	44145	Recruiting
89bio Clinical Study Site	East Greenwich	Rhode Island	02818	Recruiting
89bio Clinical Study Site	Charleston	South Carolina	29425	Recruiting
89bio Clinical Study Site	Columbia	South Carolina	29204	Recruiting
89bio Clinical Study Site	Chattanooga	Tennessee	37421	Recruiting
89bio Clinical Study Site	Cordova	Tennessee	38018	Recruiting
89bio Clinical Study Site	Hermitage	Tennessee	37076	Recruiting
89bio Clinical Study Site	Nashville	Tennessee	37211	Recruiting
89bio Clinical Study Site	Amarillo	Texas	79106	Recruiting
89bio Clinical Study Site	Austin	Texas	78745	Recruiting
89bio Clinical Study Site	Austin	Texas	78757-8051	Recruiting
89bio Clinical Study Site	Austin	Texas	78757	Recruiting
89bio Clinical Study Site	Bellaire	Texas	77401	Recruiting
89bio Clinical Study Site	Brownsville	Texas	78520	Recruiting
89bio Clinical Study Site	Corpus Christi	Texas	78404	Recruiting
89bio Clinical Study Site	DeSoto	Texas	75115	Recruiting
89bio Clinical Study Site	Edinburg	Texas	78539	Recruiting
89bio Clinical Study Site	Farmers Branch	Texas	75234	Recruiting
89bio Clinical Study Site	Fort Sam Houston	Texas	78234	Terminated
89bio Clinical Study Site	Fort Worth	Texas	76104	Recruiting
89bio Clinical Study Site	Garland	Texas	75044	Recruiting
89bio Clinical Study Site	Georgetown	Texas	78626	Recruiting
89bio Clinical Study Site	Georgetown	Texas	78628	Recruiting
89bio Clinical Study Site	Houston	Texas	77030	Recruiting
89bio Clinical Study Site	Houston	Texas	77099	Recruiting
89bio Clinical Study Site	Katy	Texas	77494	Recruiting
89bio Clinical Study Site	San Antonio	Texas	78209	Recruiting
89bio Clinical Study Site	San Antonio	Texas	78215	Recruiting
89bio Clinical Study Site	San Antonio	Texas	78222	Recruiting
89bio Clinical Study Site	San Antonio	Texas	78229-4801	Recruiting
89bio Clinical Study Site	San Antonio	Texas	78229	Recruiting
89bio Clinical Study Site	Stafford	Texas	77477	Recruiting
89bio Clinical Study Site	Tomball	Texas	77584	Recruiting
89bio Clinical Study Site	Waco	Texas	76301	Recruiting
89bio Clinical Study Site	Waco	Texas	76710	Recruiting
89bio Clinical Study Site	Ogden	Utah	84405	Recruiting
89bio Clinical Study Site	Richmond	Virginia	23226-1925	Recruiting
89bio Clinical Study Site	Richmond	Virginia	23229	Terminated
89bio Clinical Study Site	Richmond	Virginia	23236	Recruiting
89bio Clinical Study Site	Richmond	Virginia	23298	Recruiting
89bio Clinical Study Site	Roanoke	Virginia	24014	Recruiting
89bio Clinical Study Site	Seattle	Washington	98101	Recruiting
89bio Clinical Study Site	Seattle	Washington	98105	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 207 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06318169, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 4, 2026 · Synced May 6, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06318169 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →