Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread
Public ClinicalTrials.gov record NCT06324357. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Beamion BCGC-1: A Phase Ib Dose Escalation and Phase II Dose Optimization, Randomized, Open-label, Multicenter Trial of Oral Zongertinib (BI 1810631) Alone or in Combination With Other Agents for the Treatment of Patients With Advanced HER2+ Metastatic Breast Cancer (mBC), Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (mGEAC), or Metastatic Colorectal Cancer (mCRC)
Study identification
- NCT ID
- NCT06324357
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Lead sponsor
- Boehringer Ingelheim
- Industry
- Enrollment
- 768 participants
Conditions and interventions
Conditions
Interventions
- Capecitabine Drug
- Trastuzumab Drug
- Trastuzumab deruxtecan Drug
- Trastuzumab emtansine Drug
- Zongertinib Drug
- mFOLFOX6 Drug
- zanidatamab Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 2, 2024
- Primary completion
- Jan 7, 2029
- Completion
- Jan 7, 2029
- Last update posted
- Apr 28, 2026
2024 – 2029
United States locations
- U.S. sites
- 29
- U.S. states
- 17
- U.S. cities
- 23
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Mayo Clinic-Arizona | Phoenix | Arizona | 85054 | Not yet recruiting |
| The Oncology Institute of Hope and Innovation | Cerritos | California | 90703 | Not yet recruiting |
| Ellison Medical Institute | Los Angeles | California | 90064 | Not yet recruiting |
| Valkyrie Clinical Trials | Los Angeles | California | 90067 | Recruiting |
| University of California Los Angeles | Los Angeles | California | 90095 | Not yet recruiting |
| University of California Irvine | Orange | California | 92868 | Recruiting |
| Sharp Memorial Hospital | San Diego | California | 92123 | Not yet recruiting |
| Yale University School of Medicine | New Haven | Connecticut | 06510 | Recruiting |
| Mayo Clinic - Florida | Jacksonville | Florida | 32224 | Not yet recruiting |
| H. Lee Moffitt Cancer Center and Research Institute | Tampa | Florida | 33612 | Not yet recruiting |
| Orchard Healthcare Research Inc.- Skokie | Skokie | Illinois | 60077 | Not yet recruiting |
| Community Health Network | Indianapolis | Indiana | 46250 | Not yet recruiting |
| University of Iowa Hospitals and Clinics | Iowa City | Iowa | 52242 | Recruiting |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | Not yet recruiting |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02215 | Not yet recruiting |
| University of Michigan | Ann Arbor | Michigan | 48109 | Not yet recruiting |
| Mayo Clinic, Rochester | Rochester | Minnesota | 55905 | Not yet recruiting |
| Memorial Sloan-Kettering Cancer Center | New York | New York | 10065 | Not yet recruiting |
| New York Cancer & Blood Specialists | Shirley | New York | 11967 | Not yet recruiting |
| Penn State Milton S. Hershey Medical Center | Hershey | Pennsylvania | 17033 | Not yet recruiting |
| Avera Cancer Institute | Sioux Falls | South Dakota | 57105 | Not yet recruiting |
| Baptist Cancer Center - Memphis | Memphis | Tennessee | 38120 | Not yet recruiting |
| SCRI Oncology Partners | Nashville | Tennessee | 37203 | Recruiting |
| Tennessee Oncology, Pllc | Nashville | Tennessee | 37203 | Recruiting |
| The Methodist Hospital Research Institute | Houston | Texas | 77030 | Not yet recruiting |
| The University of Texas MD Anderson Cancer Center | Houston | Texas | 77030 | Not yet recruiting |
| Inova Schar Cancer Institute | Fairfax | Virginia | 22031 | Not yet recruiting |
| Virginia Cancer Specialists, PC | Fairfax | Virginia | 22031 | Recruiting |
| Fred Hutchinson Cancer Research Center | Seattle | Washington | 98109 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 79 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06324357, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 28, 2026 · Synced May 8, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06324357 live on ClinicalTrials.gov.