A Study of Lebrikizumab (LY3650150) in Participants With Chronic Rhinosinusitis and Nasal Polyps Treated With Intranasal Corticosteroids (CONTRAST-NP)

ClinicalTrials.gov ID: NCT06338995

Public ClinicalTrials.gov record NCT06338995. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

View official ClinicalTrials.gov record → Back to search

ClinicalTrials.gov public records Last synced Sep 6, 2026, 12:28 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Efficacy and Safety of Lebrikizumab/LY3650150 in Participants With Chronic Rhinosinusitis With Nasal Polyps on Background Intranasal Corticosteroids

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The main purpose of this study is to evaluate the efficacy and safety of lebrikizumab in participants with chronic rhinosinusitis and nasal polyps treated with intranasal corticosteroids. The study will last about 18 months.

Study identification

NCT ID: NCT06338995
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Eli Lilly and Company; Industry
Enrollment: 510 participants

Conditions and interventions

Conditions

Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)

Interventions

Drug

Eligibility (public fields only)

Age range: 12 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Apr 28, 2024
Primary completion: Apr 30, 2027
Completion: Feb 29, 2028
Last update posted: Aug 23, 2026

2024 – 2028

United States locations

U.S. sites: 41
U.S. states: 19
U.S. cities: 35

Facility	City	State	ZIP	Site status
AllerVie Clinical Research	Birmingham	Alabama	35209	Not yet recruiting
University of Alabama at Birmingham	Birmingham	Alabama	35233	Recruiting
Medovation Research	Huntsville	Alabama	35801	Not yet recruiting
Novak Clinical Research - Tucson - North La Cholla Boulevard	Tucson	Arizona	85741	Recruiting
Keck Medicine of USC	Arcadia	California	91007	Not yet recruiting
University of California, Irvine	Irvine	California	92697	Recruiting
ADCRC	La Mesa	California	91942	Not yet recruiting
Ark Clinical Research	Long Beach	California	90815	Not yet recruiting
DaVinci Research LLC	Roseville	California	95661	Recruiting
Breathe Clear Institute	Torrance	California	90503	Recruiting
Colorado ENT & Allergy	Colorado Springs	Colorado	80923	Recruiting
Bioresearch Partner-Kendale Lakes	Miami	Florida	33155	Not yet recruiting
Orlando ENT & Allergy	Orlando	Florida	32825	Not yet recruiting
NuLine Clinical Trial Center	Pompano Beach	Florida	33060	Not yet recruiting
University of South Florida	Tampa	Florida	33613	Recruiting
MJ Research	Tampa	Florida	33615	Not yet recruiting
Treasure Valley Medical Research	Boise	Idaho	83706	Recruiting
Entopy Research LLC	Chicago	Illinois	60616	Recruiting
Chicago ENT	Chicago	Illinois	60657	Recruiting
EMEDR	Overland Park	Kansas	66211	Not yet recruiting
South Louisiana Ear, Nose, Throat & Facial Plastic Surgery - PPDS	Mandeville	Louisiana	70471	Recruiting
Chesapeake Clinical Research, Inc.	White Marsh	Maryland	21162	Recruiting
Brigham and Women's Hospital	Boston	Massachusetts	02215	Recruiting
University of Missouri	Columbia	Missouri	65212	Recruiting
Washington University School of Medicine	St Louis	Missouri	63141	Not yet recruiting
Circuit Clinical/Mercer Allergy and Pulmonary Associates	Hamilton	New Jersey	08619	Not yet recruiting
Madison ENT & Facial Plastic Surgery	New York	New York	10016	Recruiting
New York Allergy and Sinus Center	New York	New York	10016	Recruiting
Equity Medical	The Bronx	New York	10455	Recruiting
UCMC	Cincinnati	Ohio	45267	Not yet recruiting
Optimed Research, LTD	Columbus	Ohio	43235	Recruiting
Charleston ENT	Charleston	South Carolina	29406	Not yet recruiting
Medical University of South Carolina- Department of Otolaryngology and Head and Neck Surgery	Charleston	South Carolina	29425	Not yet recruiting
Alina Clinical Trials	Dallas	Texas	75209	Recruiting
UT Southwestern Medical Center	Dallas	Texas	75390-9035	Not yet recruiting
University of Texas Physicians Department of Otorhinolaryngology Clinc	Houston	Texas	77030	Recruiting
Ear Nose and Throat Associates of Texas PA	McKinney	Texas	75070-5735	Recruiting
Alamo ENT Associates	San Antonio	Texas	78258-3227	Recruiting
Eastern Virginia Medical School	Norfolk	Virginia	23507	Recruiting
Richmond Ear Nose and Throat	Richmond	Virginia	23235	Not yet recruiting
The Medical College of Wisconsin	Milwaukee	Wisconsin	53226-3548	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 159 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06338995, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Aug 23, 2026 · Synced Sep 6, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06338995 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →