ClinicalTrials.gov record
Impact of Discontinuing Hypertonic Saline in People With CF on Highly Effective CFTR Modulators- A SIMPLIFY Sub-Study
ClinicalTrials.gov ID: NCT06350461
Public ClinicalTrials.gov record NCT06350461. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 6, 2026, 8:59 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Master Protocol to Test the Impact of Discontinuing Chronic Therapies in People With Cystic Fibrosis on Highly Effective CFTR Modulator Therapy - Hypertonic Saline
Study identification
- NCT ID
- NCT06350461
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Not applicable
- Lead sponsor
- Nicole Hamblett
- Other
- Enrollment
- 370 participants
Conditions and interventions
Conditions
Interventions
- Continuation of hypertonic saline (HS) Other
- Discontinuation of hypertonic saline (HS) Other
Other
Eligibility (public fields only)
- Age range
- 12 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 24, 2020
- Primary completion
- Jul 10, 2022
- Completion
- Jul 10, 2022
- Last update posted
- Sep 30, 2024
2020 – 2022
United States locations
- U.S. sites
- 81
- U.S. states
- 38
- U.S. cities
- 72
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| Providence Alaska Medical Center | Anchorage | Alaska | 99508 | — |
| Tucson Cystic Fibrosis Center | Tucson | Arizona | 85724 | — |
| Arkansas Children's Hospital | Little Rock | Arkansas | 72202 | — |
| Miller Children's and Women's Hospital Long Beach | Long Beach | California | 90806 | — |
| CHOC Children's Hospital | Orange | California | 92868 | — |
| Stanford University Medical Center | Palo Alto | California | 94304 | — |
| Rady Children's Hospital and Health Center at the University of California San Diego | San Diego | California | 92123 | — |
| University of California, San Francisco - Adult Center | San Francisco | California | 94143 | — |
| University of California, San Francisco - Peds Center | San Francisco | California | 94158 | — |
| Children's Hospital Colorado | Aurora | Colorado | 80045 | — |
| National Jewish Health | Denver | Colorado | 80206 | — |
| Yale University School of Medicine | New Haven | Connecticut | 06520 | — |
| University of Florida | Gainesville | Florida | 32610 | — |
| Nemours Children's Clinic - Jacksonville | Jacksonville | Florida | 32207 | — |
| Central Florida Pulmonary Group | Orlando | Florida | 32803 | — |
| The Nemours Children's Clinic - Orlando | Orlando | Florida | 32827 | — |
| Nemours Children's Clinic - Pensacola | Pensacola | Florida | 32514 | — |
| All Children's Hospital | St. Petersburg | Florida | 33701 | — |
| Tampa General Hospital | Tampa | Florida | 33606 | — |
| Emory University | Atlanta | Georgia | 30324 | — |
| Saint Luke's Cystic Fibrosis Center of Idaho | Boise | Idaho | 83702 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| OSF Saint Francis Medical Center | Peoria | Illinois | 61637 | — |
| Riley Hospital for Children | Indianapolis | Indiana | 46202 | — |
| University of Iowa | Iowa City | Iowa | 52242 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| University of Kentucky | Lexington | Kentucky | 40506 | — |
| University of Louisville | Louisville | Kentucky | 40202 | — |
| Tulane University | Metairie | Louisiana | 70001 | — |
| Maine Medical Partners Pediatric Specialty Care | Portland | Maine | 04102 | — |
| Johns Hopkins University | Baltimore | Maryland | 21287 | — |
| Boston Children's Hospital | Boston | Massachusetts | 02115 | — |
| University of Michigan, Michigan Medicine | Ann Arbor | Michigan | 48109 | — |
| Wayne State University Harper University Hospital | Detroit | Michigan | 48201 | — |
| Corewell Health Helen DeVos | Grand Rapids | Michigan | 49546 | — |
| Children's Hospitals and Clinics of Minnesota | Minneapolis | Minnesota | 55404 | — |
| The Minnesota Cystic Fibrosis Center | Minneapolis | Minnesota | 55455 | — |
| Children's Mercy Kansas City | Kansas City | Missouri | 64108 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Billings Clinic | Billings | Montana | 59101 | — |
| Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | — |
| Monmouth Medical Center | Eatontown | New Jersey | 07724 | — |
| Morristown Medical Center | Morristown | New Jersey | 07960 | — |
| Rutgers - Robert Wood Johnson Medical School | New Brunswick | New Jersey | 08903 | — |
| Cohen Children's Medical Center of New York | New Hyde Park | New York | 11042 | — |
| Beth Israel Medical Center | New York | New York | 10003 | — |
| Lenox Hill Hospital Cystic Fibrosis Center | New York | New York | 10028 | — |
| Columbia University Cystic Fibrosis Program | New York | New York | 10032 | — |
| University of Rochester Medical Center Strong Memorial | Rochester | New York | 14642 | — |
| SUNY Upstate Medical University | Syracuse | New York | 13210 | — |
| New York Medical College at Westchester Medical Center | Valhalla | New York | 10595 | — |
| University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | 27517 | — |
| Atrium Health Wake Forest Baptist | Winston-Salem | North Carolina | 27157 | — |
| Children's Hospital Medical Center of Akron | Akron | Ohio | 44308 | — |
| Cincinnati Children's Hospital Medical Center | Cincinnati | Ohio | 45229 | — |
| Rainbow Babies and Children's Hospital/University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44146 | — |
| Cleveland Clinic Cystic Fibrosis Program | Cleveland | Ohio | 44195 | — |
| Nationwide Children's Hospital | Columbus | Ohio | 43205 | — |
| Dayton Children's Hospital | Dayton | Ohio | 45404 | — |
| Oregon Health & Sciences University | Portland | Oregon | 97239 | — |
| Hershey Medical Center Pennsylvania State University | Hershey | Pennsylvania | 17033 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| University of Pittsburgh Medical Center | Pittsburgh | Pennsylvania | 15224 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Dell Children's Medical Center of Central Texas | Austin | Texas | 78723 | — |
| University of Texas Southwestern / Children's Health | Dallas | Texas | 75207 | — |
| University of Texas Southwestern | Dallas | Texas | 75390 | — |
| Cook Children's Medical Center | Fort Worth | Texas | 76104 | — |
| University of Texas Health Center at Tyler | Tyler | Texas | 75708 | — |
| Primary Children's Cystic Fibrosis Center | Salt Lake City | Utah | 84113 | — |
| University of Vermont Medical Center | Burlington | Vermont | 05401 | — |
| University of Virginia | Charlottesville | Virginia | 22904 | — |
| Virginia Commonwealth University | Richmond | Virginia | 23219 | — |
| Seattle Children's Hospital | Seattle | Washington | 98105 | — |
| University of Washington Medical Center | Seattle | Washington | 98195 | — |
| Providence Medical Group, Cystic Fibrosis Clinic | Spokane | Washington | 99204 | — |
| West Virginia University - Morgantown | Morgantown | West Virginia | 26506 | — |
| University of Wisconsin | Madison | Wisconsin | 53792 | — |
| Children's Wisconsin | Milwaukee | Wisconsin | 53226 | — |
| Froedtert & Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06350461, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 30, 2024 · Synced May 6, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06350461 live on ClinicalTrials.gov.