Study to Compare the Effectiveness and Safety of Golcadomide Plus R-CHOP vs Placebo Plus R-CHOP in Participants With Previously Untreated High-risk Large B-cell Lymphoma
Public ClinicalTrials.gov record NCT06356129. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study Comparing the Efficacy and Safety of Golcadomide Plus R-CHOP Chemotherapy vs Placebo Plus R-CHOP Chemotherapy in Participants With Previously Untreated High-risk Large B-cell Lymphoma (GOLSEEK-1)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to compare the effectiveness and safety of golcadomide in combination with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) chemotherapy vs placebo in combination with R-CHOP chemotherapy in participants with previously untreated high-risk large B-cell lymphoma (LBCL).
Study identification
- NCT ID
- NCT06356129
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 850 participants
Conditions and interventions
Conditions
Interventions
- Golcadomide Drug
- Placebo Drug
- Rituximab Drug
- Cyclophosphamide Drug
- Doxorubicin Drug
- Vincristine Drug
- Prednisone Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 19, 2024 (Actual)
- Primary completion
- Aug 9, 2027 (Estimated)
- Completion
- Jun 26, 2029 (Estimated)
- Last update posted
- Jul 6, 2026
2024 – 2029
United States locations
- U.S. sites
- 46
- U.S. states
- 24
- U.S. cities
- 41
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Local Institution - 0014 | Mobile | Alabama | 36604 | — |
| Local Institution - 0477 | Anchorage | Alaska | 99508 | — |
| Local Institution - 0452 | Phoenix | Arizona | 85054 | — |
| Local Institution - 0342 | San Francisco | California | 94143 | — |
| Local Institution - 0497 | Fort Myers | Florida | 33901 | — |
| Local Institution - 0287 | Jacksonville | Florida | 32224 | — |
| Local Institution - 0415 | Margate | Florida | 33063 | — |
| Local Institution - 0045 | Miami Beach | Florida | 33140 | — |
| Local Institution - 0012 | Pensacola | Florida | 32504 | — |
| Local Institution - 0502 | St. Petersburg | Florida | 33705 | — |
| Local Institution - 0414 | Tampa | Florida | 33612 | — |
| Local Institution - 0192 | West Palm Beach | Florida | 33401 | — |
| Local Institution - 0485 | Weston | Florida | 33331 | — |
| Local Institution - 0515 | Atlanta | Georgia | 30303 | — |
| Local Institution - 0303 | Atlanta | Georgia | 30322 | — |
| Local Institution - 0182 | Chicago | Illinois | 60611 | — |
| Local Institution - 0048 | Skokie | Illinois | 60077 | — |
| Local Institution - 0461 | Waukee | Iowa | 50309 | — |
| Local Institution - 0031 | Westwood | Kansas | 66205 | — |
| Local Institution - 0436 | Edgewood | Kentucky | 41017 | — |
| Local Institution - 0408 | Baton Rouge | Louisiana | 70809 | — |
| Local Institution - 0478 | Ann Arbor | Michigan | 48109 | — |
| Local Institution - 0067 | Minneapolis | Minnesota | 55407 | — |
| Local Institution - 0203 | Rochester | Minnesota | 55905 | — |
| Local Institution - 0437 | Kansas City | Missouri | 64132 | — |
| Local Institution - 0466 | Reno | Nevada | 89511 | — |
| Local Institution - 0498 | East Brunswick | New Jersey | 08816 | — |
| Local Institution - 0480 | Hackensack | New Jersey | 07601 | — |
| Local Institution - 0049 | Morristown | New Jersey | 07960 | — |
| Local Institution - 0175 | New Brunswick | New Jersey | 08901 | — |
| Local Institution - 0190 | Buffalo | New York | 14263 | — |
| Local Institution - 0451 | East Syracuse | New York | 13057 | — |
| Local Institution - 0484 | New York | New York | 10016 | — |
| Local Institution - 0369 | New York | New York | 10028 | — |
| Local Institution - 0176 | New York | New York | 10029 | — |
| Local Institution - 0174 | Chapel Hill | North Carolina | 27599 | — |
| Local Institution - 0066 | Massillon | Ohio | 44646 | — |
| Local Institution - 0450 | Tulsa | Oklahoma | 74146 | — |
| Local Institution - 0179 | Portland | Oregon | 97239 | — |
| Local Institution - 0009 | Pittsburgh | Pennsylvania | 15232 | — |
| Local Institution - 0419 | York | Pennsylvania | 17403 | — |
| Local Institution - 0435 | Fort Sam Houston | Texas | 78234 | — |
| Local Institution - 0516 | Houston | Texas | 77026 | — |
| Local Institution - 0046 | Houston | Texas | 77030 | — |
| Local Institution - 0424 | Houston | Texas | 77030 | — |
| Local Institution - 0293 | Richmond | Virginia | 23298 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 279 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06356129, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 6, 2026 · Synced Oct 28, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06356129 live on ClinicalTrials.gov.