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Recruiting Phase 3 Interventional

Saruparib (AZD5305) Plus Camizestrant or Plus Endocrine Therapy, Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer

ClinicalTrials.gov ID: NCT06380751

Public ClinicalTrials.gov record NCT06380751. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 1, 2026, 1:48 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomised, Open-Label, Phase III Study of Saruparib (AZD5305) Plus Camizestrant or Plus Endocrine Therapy, Compared With Physician's Choice CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant for the First-Line Treatment of Patients With BRCA1, BRCA2, or PALB2 Mutations and Hormone Receptor Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified) Advanced Breast Cancer (EvoPAR-Breast01)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The primary objective of the study is to measure efficacy of saruparib (AZD5305) plus camizestrant compared with physician's choice CDK4/6i plus ET in patients with BRCA1, BRCA2, or PALB2m, HR-positive, HER2-negative (defined as IHC 0, 1+, 2+/ ISH non-amplified) advanced breast cancer

Study identification

NCT ID
NCT06380751
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
AstraZeneca
Industry
Enrollment
788 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jul 31, 2024
Primary completion
Dec 17, 2029
Completion
Dec 29, 2031
Last update posted
Jul 29, 2026

2024 – 2031

United States locations

U.S. sites
55
U.S. states
22
U.S. cities
50
Facility City State ZIP Site status
Research Site Gilbert Arizona 85234 Recruiting
Research Site Fountain Valley California 92708 Recruiting
Research Site Glendale California 91206 Recruiting
Research Site Los Angeles California 90089 Recruiting
Research Site Newport Beach California 92663 Recruiting
Research Site Aurora Colorado 80045 Recruiting
Research Site Grand Junction Colorado 81501 Withdrawn
Research Site Hollywood Florida 33021 Recruiting
Research Site Jacksonville Florida 32224 Recruiting
Research Site Orlando Florida 32806 Withdrawn
Research Site Arlington Heights Illinois 60005 Recruiting
Research Site Chicago Illinois 60611 Recruiting
Research Site Evanston Illinois 60201 Recruiting
Research Site Park Ridge Illinois 60068 Withdrawn
Research Site Urbana Illinois 61801 Recruiting
Research Site Winfield Illinois 60190 Recruiting
Research Site Indianapolis Indiana 46227 Withdrawn
Research Site Louisville Kentucky 40207 Withdrawn
Research Site Baltimore Maryland 21201 Not yet recruiting
Research Site Silver Spring Maryland 20902 Withdrawn
Research Site Silver Spring Maryland 20904 Recruiting
Research Site Boston Massachusetts 02215 Recruiting
Research Site Dearborn Michigan 48126 Withdrawn
Research Site Detroit Michigan 48202 Withdrawn
Research Site Royal Oak Michigan 48073 Recruiting
Research Site Rochester Minnesota 55905 Recruiting
Research Site Saint Joseph Missouri 64507 Recruiting
Research Site Springfield Missouri 65804 Recruiting
Research Site St Louis Missouri 63110 Not yet recruiting
Research Site Camden New Jersey 08103 Recruiting
Research Site New Brunswick New Jersey 08901 Withdrawn
Research Site Brooklyn New York 11220 Withdrawn
Research Site Mineola New York 11501 Recruiting
Research Site New Hyde Park New York 11042 Withdrawn
Research Site New York New York 10016 Recruiting
Research Site New York New York 10028 Withdrawn
Research Site New York New York 10065 Recruiting
Research Site Shirley New York 11967 Withdrawn
Research Site Stony Brook New York 11790 Recruiting
Research Site The Bronx New York 10469 Withdrawn
Research Site Westbury New York 11590 Withdrawn
Research Site Hershey Pennsylvania 17033 Recruiting
Research Site Philadelphia Pennsylvania 19104 Recruiting
Research Site Pittsburgh Pennsylvania 15212 Not yet recruiting
Research Site Pittsburgh Pennsylvania 15215 Recruiting
Research Site West Columbia South Carolina 29169 Withdrawn
Research Site Chattanooga Tennessee 37404 Recruiting
Research Site Nashville Tennessee 37203 Recruiting
Research Site Houston Texas 77030 Recruiting
Research Site Houston Texas 77054 Recruiting
Research Site San Antonio Texas 78240 Recruiting
Research Site Norfolk Virginia 23502 Recruiting
Research Site Tacoma Washington 98405 Recruiting
Research Site Morgantown West Virginia 26506 Recruiting
Research Site Milwaukee Wisconsin 53215 Withdrawn

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 244 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT06380751, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Jul 29, 2026 · Synced Sep 1, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06380751 live on ClinicalTrials.gov.

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