A Randomized, Controlled, Safety and Tolerability Study of VRDN-001 in Participants With Thyroid Eye Disease (TED)
Public ClinicalTrials.gov record NCT06384547. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Controlled, Safety and Tolerability Study of VRDN-001, a Humanized Monoclonal Antibody Directed Against the IGF-1 Receptor, in Participants With Thyroid Eye Disease (TED)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The investigational drug, VRDN-001, is a monoclonal antibody that inhibits the activity of a cell surface receptor called insulin-like growth factor-1 receptor (IGF-1R). Inhibition of IGF-1R may help to reduce the inflammation and associated tissue swelling that occurs in participants with TED. The primary objective of this clinical trial is to evaluate the safety and tolerability of VRDN-001 in participants with TED.
Study identification
- NCT ID
- NCT06384547
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 231 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 23, 2024 (Actual)
- Primary completion
- May 1, 2025 (Actual)
- Completion
- Jan 19, 2026 (Actual)
- Last update posted
- Aug 13, 2026
2024 – 2026
United States locations
- U.S. sites
- 26
- U.S. states
- 14
- U.S. cities
- 23
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| United Medical Research Institute | Inglewood | California | 90301 | — |
| Advancing Research International, LLC | Los Angeles | California | 90023 | — |
| Stanford Byers Eye Institute | Palo Alto | California | 94303 | — |
| Cockerham Eye Consultants, PC | San Diego | California | 92108 | — |
| FOMAT Medical Research | Santa Maria | California | 93454 | — |
| University of Colorado - Dept of Ophthalmology | Aurora | Colorado | 80045 | — |
| Sina Medical Center LLC | Homestead | Florida | 33034 | — |
| Med-Care Research Inc. | Miami | Florida | 33125 | — |
| Edward Jenner Research Group Center LLC | Plantation | Florida | 33317 | — |
| Sarasota Retina Institute | Sarasota | Florida | 34231 | — |
| Vision Medical Research Inc. | Orland Park | Illinois | 60462 | — |
| University Health Diabetes, Endocrinology & Nephrology Center | Kansas City | Kansas | 64108 | — |
| KU Medical Center, University of Kansas | Kansas City | Kansas | 66103 | — |
| Massachusetts Eye and Ear | Boston | Massachusetts | 02114 | — |
| Ophthalmic Consultants of Boston | Weymouth | Massachusetts | 02189 | — |
| Fraser Eye Care Center | Fraser | Michigan | 48026 | — |
| Kahana Oculoplastic & Orbital Surgery | Livonia | Michigan | 48152 | — |
| University of Minnesota, Department of Ophthalmology and Visual Neurosciences | Minneapolis | Minnesota | 55455 | — |
| Advancing Research International, LLC | Las Vegas | Nevada | 89144 | — |
| Rutgers- New Jersey Medical School- Newark | Newark | New Jersey | 07103 | — |
| New York Eye Ear Infirmary of Mount Sinai | New York | New York | 10003 | — |
| Baylor College of Medicine (BCM) - Ophthalmology | Houston | Texas | 77030 | — |
| Neuro-Eye Clinical Trials | Houston | Texas | 77074 | — |
| Neuro-Ophthalmology of Texas, PLLC | Houston | Texas | 77074 | — |
| University of Vermont Medical Center | Burlington | Vermont | 05401 | — |
| West Virginia University Eye Institute | Morgantown | West Virginia | 26506 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 24 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06384547, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 13, 2026 · Synced Oct 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06384547 live on ClinicalTrials.gov.