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Recruiting Phase 3 Interventional

A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma

ClinicalTrials.gov ID: NCT06388733

Public ClinicalTrials.gov record NCT06388733. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 20, 2026, 4:09 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3, Open-label, Randomized 2-arm Study Comparing the Clinical Efficacy and Safety of Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma

Study identification

NCT ID
NCT06388733
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
Ivy Brain Tumor Center
Other
Enrollment
450 participants

Conditions and interventions

Interventions

  • Niraparib Drug
  • Temozolomide Drug

Drug

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jun 18, 2024
Primary completion
Nov 30, 2027
Completion
Feb 29, 2028
Last update posted
Mar 31, 2026

2024 – 2028

United States locations

U.S. sites
32
U.S. states
22
U.S. cities
30
Facility City State ZIP Site status
University of Alabama at Birmingham Birmingham Alabama 35233 Recruiting
Ivy Brain Tumor Center Phoenix Arizona 85013 Recruiting
Scripps Cancer Center La Jolla California 92037 Recruiting
Moores UCSD Cancer Center La Jolla California 92093 Recruiting
Smilow Cancer Hospital at Yale New Haven Guilford Connecticut 06437 Recruiting
Indiana University Indianapolis Indiana 46202 Recruiting
The NeuroMedical Center Baton Rouge Louisiana 70809 Recruiting
MaineHealth Maine Medical Center Care South Portland Maine 04106 Recruiting
Tufts Medical Center Boston Massachusetts 02111 Recruiting
University of Michigan Rogel Cancer Center Ann Arbor Michigan 48109 Recruiting
Allina Health Minneapolis Minnesota 55407 Recruiting
University of Minnesota Health Clinics and Surgery Center, Minneapolis Minneapolis Minnesota 55455 Recruiting
Saint Lukes Neuro Oncology Kansas City Missouri 64111 Recruiting
Washington University, School of Medicine St Louis Missouri 63110 Recruiting
Jersey Shore University Medical Center Neptune City New Jersey 07753 Recruiting
Atlantic Health System Summit New Jersey 07901 Recruiting
Northwell Health New Hyde Park New York 11042 Recruiting
New York University Ambulatory Care Center New York New York 10016 Recruiting
Montefiore Medical Center The Bronx New York 10461 Recruiting
Duke Cancer Center Brain Tumor Clinic Durham North Carolina 27710 Recruiting
Wake Forest Baptist Health Winston-Salem North Carolina 27157 Recruiting
University of Cincinnati Cancer Institute Cincinnati Ohio 45267 Recruiting
The Cleveland Clinic Foundation Cleveland Ohio 44195 Recruiting
The Ohio State University Columbus Ohio 43210 Recruiting
Providence Portland Medical Center Portland Oregon 97213 Recruiting
Thomas Jefferson University Philadelphia Pennsylvania 19107 Recruiting
University of Pittsburgh Medical Center Health System Pittsburgh Pennsylvania 15232 Recruiting
Medical University of South Carolina - Department of Neurosurgery Charleston South Carolina 29425 Recruiting
Baylor Scott & White Health Temple Texas 76508 Recruiting
The University of Vermont Medical Center Burlington Vermont 05401 Recruiting
University of Washington Medical Center Seattle Washington 98109 Recruiting
University of Wisconsin Cancer Center Madison Wisconsin 53706 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 63 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT06388733, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Mar 31, 2026 · Synced May 20, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06388733 live on ClinicalTrials.gov.

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