A Study of Upadacitinib in Adult Participants With Moderate-to-Severe Atopic Dermatitis and Inadequate Response to Dupilumab
Public ClinicalTrials.gov record NCT06389136. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3b/4 Randomized, Open-label, Efficacy Assessor-Blinded Study, to Evaluate the Efficacy and Safety of Upadacitinib for the Treatment of Adult Subjects With Moderate to Severe Atopic Dermatitis and Inadequate Response to Dupilumab (SWITCH-UP)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Atopic dermatitis (AD) is a skin condition that may cause a rash and itching due to inflammation of the skin. Therapies spread over the skin may not be enough to control the AD in trial participants who require systemic anti-inflammatory treatment. This study aims to provide data on the efficacy and safety of upadacitinib at different doses in adult participants with moderate to severe AD. Upadacitinib is an approved drug for the treatment of moderate to severe atopic dermatitis (AD). This study is conducted in 2 periods. During Period 1, participants are randomly assigned into 1 of 2 groups called treatment arms to receive upadacitinib 15mg or dupilumab 300mg. Based on the participants response to upadacitinib 15mg, they may have their dose increased to upadacitinib 30mg after 2 weeks. In Period 2, participants that completed Period 1 will either remain on their assigned dose or be reassigned to a different dose based on their Eczema Area and Severity Index (EASI) response. Approximately 200 adult participants ages 18 to less than 64 with moderate to severe AD who are current users of dupilumab and had a history of inadequate response to dupilumab will be enrolled at up to 130 sites worldwide. The study is comprised of a 35-day Screening Period, an 8-week Open-Label Period 1 and a 24-week Open-Label Period 2 for participants that completed Period 1. Participants will receive upadacitinib oral tablets once daily or dupilumab subcutaneous (SC) injection every other week for 32 weeks and followed for 30 days. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.
Study identification
- NCT ID
- NCT06389136
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 184 participants
Conditions and interventions
Conditions
Interventions
- Upadacitinib 15mg Dose Drug
- Dupilumab 300mg Dose Drug
- Upadacitinib 30mg Dose Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 63 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 14, 2024 (Actual)
- Primary completion
- Nov 2026 (Estimated)
- Completion
- May 2027 (Estimated)
- Last update posted
- Oct 16, 2026
2024 – 2027
United States locations
- U.S. sites
- 84
- U.S. states
- 28
- U.S. cities
- 73
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Cahaba Dermatology and Skin Health Center /ID# 263855 | Birmingham | Alabama | 35244 | — |
| One Of A Kind Clinical Research Center - Scottsdale /ID# 278675 | Scottsdale | Arizona | 85253 | — |
| Clinical Trials Institute - Northwest Arkansas /ID# 267290 | Fayetteville | Arkansas | 72703 | — |
| Exalt Clinical Research /ID# 281611 | Chula Vista | California | 91910 | — |
| Private Practice - Dr. Tooraj Raoof /ID# 263849 | Encino | California | 91436 | — |
| First Oc Dermatology /ID# 263349 | Fountain Valley | California | 92708 | — |
| NorCal Medical Research /ID# 278397 | Greenbrae | California | 94904 | — |
| Allergy & Asthma Associates of Southern California - Mission Viejo /ID# 266574 | Mission Viejo | California | 92691 | — |
| Dermatologist Medical Group of North County- Profound Research /ID# 266512 | Oceanside | California | 92056 | — |
| Comprehensive Dermatology Center of Pasadena /ID# 281014 | Pasadena | California | 91105 | — |
| Stanford University School of Medicine - Redwood City /ID# 263776 | Redwood City | California | 94063 | — |
| West Dermatology La Jolla /ID# 265014 | San Diego | California | 92121 | — |
| Clinical Trials Research Institute /ID# 263846 | Thousand Oaks | California | 91320 | — |
| Yale University School of Medicine /ID# 263836 | New Haven | Connecticut | 06510 | — |
| Clearlyderm Dermatology - West Boca /ID# 264923 | Boca Raton | Florida | 33428 | — |
| Skin Care Research Boca Raton /ID# 263733 | Boca Raton | Florida | 33486-2269 | — |
| Apex Clinical Trials /ID# 263747 | Brandon | Florida | 33511 | — |
| TrueBlue Clinical Research - Brandon /ID# 265037 | Brandon | Florida | 33511 | — |
| Life Clinical Trials - Coral Springs /ID# 267195 | Coral Springs | Florida | 33071 | — |
| Revival Research - Doral /ID# 263541 | Doral | Florida | 33122 | — |
| FXM Clinical Research Ft. Lauderdale /ID# 280911 | Fort Lauderdale | Florida | 33308 | — |
| Skin Care Research - Hollywood /ID# 263739 | Hollywood | Florida | 33021-6748 | — |
| Solutions Through Advanced Research /ID# 263392 | Jacksonville | Florida | 32256 | — |
| GSI Clinical Research /ID# 263760 | Margate | Florida | 33063-7011 | — |
| Research Associates of South Florida /ID# 267291 | Miami | Florida | 33134 | — |
| International Dermatology Research /ID# 264961 | Miami | Florida | 33144 | — |
| FAX Pharma Clinical Research /ID# 280915 | Miami | Florida | 33146 | — |
| Sullivan Dermatology /ID# 263537 | Miami | Florida | 33162 | — |
| Lenus Research and Medical Group /ID# 263779 | Miami | Florida | 33172 | — |
| Quality Research of South Florida /ID# 266496 | Miami Lakes | Florida | 33016 | — |
| Fxm Clinical Research - Miramar /ID# 280934 | Miramar | Florida | 33027 | — |
| Global Clinical Professionals (GCP) /ID# 266474 | St. Petersburg | Florida | 33705 | — |
| Skin Care Research - Tampa /ID# 263750 | Tampa | Florida | 33607-6438 | — |
| Alliance Clinical Research of Tampa /ID# 264531 | Tampa | Florida | 33615 | — |
| Encore Medical Research - Weston /ID# 278491 | Weston | Florida | 33331 | — |
| Centricity Research Columbus Dermatology /ID# 266529 | Columbus | Georgia | 31904 | — |
| Cleaver Medical Group Dermatology /ID# 263788 | Dawsonville | Georgia | 30534 | — |
| Georgia Skin and Cancer Clinic /ID# 267199 | Savannah | Georgia | 31419 | — |
| Treasure Valley Medical Research /ID# 263738 | Boise | Idaho | 83706 | — |
| DeNova Research /ID# 264513 | Chicago | Illinois | 60610 | — |
| Northwestern Medicine - Northwestern Memorial Hospital /ID# 264983 | Chicago | Illinois | 60611 | — |
| Dawes Fretzin /ID# 264534 | Indianapolis | Indiana | 46256 | — |
| Options Research Group /ID# 264564 | West Lafayette | Indiana | 47906 | — |
| Dermatology Specialists Research (DS Research) - Kentucky /ID# 263388 | Louisville | Kentucky | 40241 | — |
| Velocity Clinical Research at The Dermatology Clinic - Baton Rouge /ID# 267169 | Baton Rouge | Louisiana | 70808-4691 | — |
| Boston Specialists /ID# 265810 | Boston | Massachusetts | 02111-1901 | — |
| Beth Israel Deaconess Medical Center /ID# 263703 | Boston | Massachusetts | 02215 | — |
| Beacon Clinical Research /ID# 263843 | Quincy | Massachusetts | 02169 | — |
| Great Lakes Research Group - Bay City /ID# 263535 | Bay City | Michigan | 48706 | — |
| Henry Ford Medical Center - New Center One /ID# 263522 | Detroit | Michigan | 48202-3046 | — |
| Onyx Clinical Research - Flint - South Linden Road /ID# 267773 | Flint | Michigan | 48532 | — |
| MediSearch Clinical Trials /ID# 263579 | Saint Joseph | Missouri | 64506 | — |
| Physician Research Collaboration, LLC /ID# 263583 | Lincoln | Nebraska | 68516 | — |
| Skin Specialists /ID# 263345 | Omaha | Nebraska | 68144 | — |
| Las Vegas Dermatology /ID# 265801 | Las Vegas | Nevada | 89144 | — |
| Skin Cancer and Dermatology Institute - Reno /ID# 263771 | Reno | Nevada | 89509 | — |
| Dartmouth Hitchcock Medical Center - Old Etna Road /ID# 263840 | Lebanon | New Hampshire | 03766 | — |
| Forest Hills Dermatology Group @ Union Turnpike /ID# 263755 | Kew Gardens | New York | 11415 | — |
| Equity Medical /ID# 265814 | New York | New York | 10023-7340 | — |
| Weill Cornell Medicine /ID# 265793 | New York | New York | 10065 | — |
| Piedmont Plastic Surgery and Dermatology - Huntersville /ID# 266545 | Huntersville | North Carolina | 28078-7961 | — |
| Vital Prospects Clinical Research Institute - Tulsa /ID# 263645 | Tulsa | Oklahoma | 74136 | — |
| Oregon Health and Science University /ID# 263736 | Portland | Oregon | 97239 | — |
| Clinical Research of Philadelphia /ID# 264972 | Philadelphia | Pennsylvania | 19114 | — |
| University of Pittsburgh Medical Center /ID# 264526 | Pittsburgh | Pennsylvania | 15213 | — |
| Dermatology Associates of Plymouth Meeting /ID# 267286 | Plymouth Meeting | Pennsylvania | 19462 | — |
| Medical University of South Carolina /ID# 263655 | Charleston | South Carolina | 29425 | — |
| Advanced Dermatology And Cosmetic Surgery - Spartanburg /ID# 267185 | Spartanburg | South Carolina | 29307 | — |
| Health Concepts /ID# 263383 | Rapid City | South Dakota | 57702 | — |
| Arlington Research Center, Inc /ID# 263665 | Arlington | Texas | 76011 | — |
| Orion Clinical Research /ID# 263658 | Austin | Texas | 78759 | — |
| Bellaire Dermatology Associates /ID# 263794 | Bellaire | Texas | 77401 | — |
| Studies in Dermatology /ID# 263335 | Cypress | Texas | 77429 | — |
| Dermatology Treatment and Research Center /ID# 265812 | Dallas | Texas | 75230 | — |
| Modern Research Associates /ID# 263852 | Dallas | Texas | 75231 | — |
| BRCR Global - Katy /ID# 267304 | Katy | Texas | 77450 | — |
| The Dermatology Institute of South Texas /ID# 267332 | McAllen | Texas | 78501 | — |
| Sms Clinical Research /ID# 278676 | Mesquite | Texas | 75149 | — |
| Texas Dermatology Research Center /ID# 264528 | Plano | Texas | 75025 | — |
| Stride Clinical Research /ID# 267331 | Sugar Land | Texas | 77479 | — |
| The Woodlands Dermatology Associates /ID# 266547 | The Woodlands | Texas | 77380 | — |
| Dermatology Associates of Tyler /ID# 264980 | Tyler | Texas | 75703 | — |
| Fred Hutchinson Cancer Center - Seattle - Fairview Avenue North /ID# 264537 | Seattle | Washington | 98109 | — |
| West Virginia Research Institute - Morgantown /ID# 264930 | Morgantown | West Virginia | 26505 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 45 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06389136, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 16, 2026 · Synced Oct 19, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06389136 live on ClinicalTrials.gov.