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Recruiting Phase 3 Interventional

A Study of Upadacitinib in Adult Participants With Moderate-to-Severe Atopic Dermatitis and Inadequate Response to Dupilumab

ClinicalTrials.gov ID: NCT06389136

Public ClinicalTrials.gov record NCT06389136. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Apr 29, 2026, 9:04 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3b/4 Randomized, Open-label, Efficacy Assessor-Blinded Study, to Evaluate the Efficacy and Safety of Upadacitinib for the Treatment of Adult Subjects With Moderate to Severe Atopic Dermatitis and Inadequate Response to Dupilumab (SWITCH-UP)

Study identification

NCT ID
NCT06389136
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
AbbVie
Industry
Enrollment
200 participants

Conditions and interventions

Interventions

  • Dupilumab 300mg Dose Drug
  • Upadacitinib 15mg Dose Drug
  • Upadacitinib 30mg Dose Drug

Drug

Eligibility (public fields only)

Age range
18 Years to 63 Years
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jun 13, 2024
Primary completion
Jul 31, 2026
Completion
Feb 28, 2027
Last update posted
Apr 13, 2026

2024 – 2027

United States locations

U.S. sites
81
U.S. states
27
U.S. cities
71
Facility City State ZIP Site status
Cahaba Dermatology & Skin Health Center /ID# 263855 Birmingham Alabama 35244 Recruiting
One Of A Kind Clinical Research Center - Scottsdale /ID# 278675 Scottsdale Arizona 85253 Recruiting
Clinical Trials Institute - Northwest Arkansas /ID# 267290 Fayetteville Arkansas 72703 Recruiting
Private Practice - Dr. Tooraj Raoof /ID# 263849 Encino California 91436 Recruiting
First OC Dermatology /ID# 263349 Fountain Valley California 92708 Recruiting
NorCal Medical Research /ID# 278397 Greenbrae California 94904 Recruiting
Allergy & Asthma Associates of Southern California - Mission Viejo /ID# 266574 Mission Viejo California 92691 Recruiting
Dermatologist Medical Group of North County- Profound Research /ID# 266512 Oceanside California 92056 Recruiting
Stanford University School of Medicine - Redwood City /ID# 263776 Redwood City California 94063 Recruiting
Integrative Skin Science and Research /ID# 264537 Sacramento California 95815 Recruiting
West Dermatology La Jolla /ID# 265014 San Diego California 92121 Recruiting
Clinical Trials Research Institute /ID# 263846 Thousand Oaks California 91320 Recruiting
Yale University School of Medicine /ID# 263836 New Haven Connecticut 06510 Recruiting
Clearlyderm Dermatology - West Boca /ID# 264923 Boca Raton Florida 33428 Completed
Skin Care Research Boca Raton /ID# 263733 Boca Raton Florida 33486-2269 Recruiting
Apex Clinical Trials /ID# 263747 Brandon Florida 33511 Completed
TrueBlue Clinical Research /ID# 265037 Brandon Florida 33511 Recruiting
Life Clinical Trials /ID# 267195 Coral Springs Florida 33071 Recruiting
Revival Research - Doral /ID# 263541 Doral Florida 33122 Completed
FXM Clinical Research Ft. Lauderdale /ID# 280911 Fort Lauderdale Florida 33308 Recruiting
Skin Care Research - Hollywood /ID# 263739 Hollywood Florida 33021-6748 Recruiting
Solutions Through Advanced Research /ID# 263392 Jacksonville Florida 32256 Completed
GSI Clinical Research, LLC /ID# 263760 Margate Florida 33063-7011 Recruiting
Research Associates of South Florida /ID# 267291 Miami Florida 33134 Recruiting
International Dermatology Research /ID# 264961 Miami Florida 33144 Recruiting
Sullivan Dermatology /ID# 263537 Miami Florida 33162 Recruiting
Lenus Research and Medical Group /ID# 263779 Miami Florida 33172 Recruiting
Quality Research of South Florida /ID# 266496 Miami Lakes Florida 33016 Completed
Fxm Clinical Research - Miramar /ID# 280934 Miramar Florida 33027 Recruiting
Global Clinical Professionals (GCP) /ID# 266474 St. Petersburg Florida 33705 Recruiting
Skin Care Research - Tampa /ID# 263750 Tampa Florida 33607-6438 Recruiting
Alliance Clinical Research of Tampa /ID# 264531 Tampa Florida 33615 Recruiting
Encore Medical Research - Weston /ID# 278491 Weston Florida 33331 Recruiting
Centricity Research Columbus Dermatology /ID# 266529 Columbus Georgia 31904 Recruiting
Cleaver Medical Group Dermatology /ID# 263788 Dawsonville Georgia 30534 Recruiting
Georgia Skin & Cancer Clinic /ID# 267199 Savannah Georgia 31419 Completed
Treasure Valley Medical Research /ID# 263738 Boise Idaho 83706 Recruiting
DeNova Research /ID# 264513 Chicago Illinois 60610 Recruiting
Northwestern University Feinberg School of Medicine /ID# 264983 Chicago Illinois 60611-2927 Recruiting
Dawes Fretzin, LLC /ID# 264534 Indianapolis Indiana 46256 Completed
Options Research Group /ID# 264564 West Lafayette Indiana 47906 Recruiting
Dermatology Specialists Research (DS Research) - Kentucky /ID# 263388 Louisville Kentucky 40241 Completed
Velocity Clinical Research at The Dermatology Clinic - Baton Rouge /ID# 267169 Baton Rouge Louisiana 70808-4691 Completed
Boston Specialists /ID# 265810 Boston Massachusetts 02111-1901 Recruiting
Beth Israel Deaconess Medical Center /ID# 263703 Boston Massachusetts 02215 Completed
Beacon Clinical Research /ID# 263843 Quincy Massachusetts 02169 Recruiting
Great Lakes Research Group - Bay City /ID# 263535 Bay City Michigan 48706 Completed
Henry Ford Medical Center - New Center One /ID# 263522 Detroit Michigan 48202-3046 Recruiting
Onyx Clinical Research - Flint - South Linden Road /ID# 267773 Flint Michigan 48532 Completed
MediSearch Clinical Trials /ID# 263579 Saint Joseph Missouri 64506 Recruiting
Physician Research Collaboration, LLC /ID# 263583 Lincoln Nebraska 68516 Recruiting
Skin Specialists /ID# 263345 Omaha Nebraska 68144 Recruiting
Las Vegas Dermatology /ID# 265801 Las Vegas Nevada 89144 Recruiting
Skin Cancer and Dermatology Institute - Reno /ID# 263771 Reno Nevada 89509 Recruiting
Dartmouth Hitchcock Medical Center - Old Etna Road /ID# 263840 Lebanon New Hampshire 03766 Recruiting
Forest Hills Dermatology Group @ Union Turnpike /ID# 263755 Kew Gardens New York 11415 Completed
Equity Medical, LLC /ID# 265814 New York New York 10023-7340 Recruiting
Weill Cornell Medicine /ID# 265793 New York New York 10065 Recruiting
Piedmont Plastic Surgery and Dermatology /ID# 266545 Huntersville North Carolina 28078-7961 Recruiting
Vital Prospects Clinical Research Institute - Tulsa /ID# 263645 Tulsa Oklahoma 74136 Completed
Oregon Health and Science University /ID# 263736 Portland Oregon 97239 Recruiting
Dermatology Partners /ID# 264972 Philadelphia Pennsylvania 19114 Recruiting
University of Pittsburgh Medical Center /ID# 264526 Pittsburgh Pennsylvania 15213 Recruiting
Dermatology Associates of Plymouth Meeting /ID# 267286 Plymouth Meeting Pennsylvania 19462 Recruiting
Medical University of South Carolina /ID# 263655 Charleston South Carolina 29425 Recruiting
ADCS - Spartanburg /ID# 267185 Spartanburg South Carolina 29307 Recruiting
Health Concepts /ID# 263383 Rapid City South Dakota 57702 Recruiting
Arlington Research Center, Inc /ID# 263665 Arlington Texas 76011 Recruiting
Orion Clinical Research /ID# 263658 Austin Texas 78759 Completed
Bellaire Dermatology Associates /ID# 263794 Bellaire Texas 77401 Completed
Studies in Dermatology LLC /ID# 263335 Cypress Texas 77429 Recruiting
Dermatology Treatment and Research Center /ID# 265812 Dallas Texas 75230 Recruiting
Modern Research Associates /ID# 263852 Dallas Texas 75231 Recruiting
BRCR Global Houston /ID# 267304 Katy Texas 77450 Recruiting
The Dermatology Institute of South Texas /ID# 267332 McAllen Texas 78501 Completed
Sms Clinical Research /ID# 278676 Mesquite Texas 75149 Recruiting
Texas Dermatology Research Center /ID# 264528 Plano Texas 75025 Completed
Stride Clinical Research /ID# 267331 Sugar Land Texas 77479 Recruiting
The Woodlands Dermatology Associates /ID# 266547 The Woodlands Texas 77380 Recruiting
Dermatology Associates of Tyler /ID# 264980 Tyler Texas 75703 Recruiting
West Virginia Research Institute - Morgantown /ID# 264930 Morgantown West Virginia 26505 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 43 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT06389136, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Apr 13, 2026 · Synced Apr 29, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06389136 live on ClinicalTrials.gov.

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