ClinicalTrials.gov record
Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab Versus TPC in TNBC Who Did Not Achieve pCR (MK-2870-012)
ClinicalTrials.gov ID: NCT06393374
Public ClinicalTrials.gov record NCT06393374. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 6, 2026, 8:28 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Open-label, Study to Compare the Efficacy and Safety of Adjuvant MK-2870 in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice (TPC) in Participants With Triple-Negative Breast Cancer (TNBC) Who Received Neoadjuvant Therapy and Did Not Achieve a Pathological Complete Response (pCR) at Surgery
Study identification
- NCT ID
- NCT06393374
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Merck Sharp & Dohme LLC
- Industry
- Enrollment
- 1,530 participants
Conditions and interventions
Conditions
Interventions
- Capecitabine Drug
- Pembrolizumab Biological
- Sacituzumab tirumotecan Biological
Drug · Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 23, 2024
- Primary completion
- Dec 15, 2030
- Completion
- Dec 13, 2037
- Last update posted
- Apr 30, 2026
2024 – 2037
United States locations
- U.S. sites
- 82
- U.S. states
- 33
- U.S. cities
- 74
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Infirmary Cancer Care ( Site 0001) | Mobile | Alabama | 36607 | Recruiting |
| Ironwood Cancer & Research Centers-Research ( Site 0054) | Chandler | Arizona | 85224 | Recruiting |
| MemorialCare Orange Coast Medical Center ( Site 9501) | Fountain Valley | California | 92708 | Recruiting |
| Scripps Cancer Center ( Site 0052) | La Jolla | California | 92037 | Recruiting |
| Cancer and Blood Specialty Clinic ( Site 0008) | Los Alamitos | California | 90720 | Completed |
| Kaiser Permanente - Oakland ( Site 0079) | Oakland | California | 94611 | Recruiting |
| Profound Research LLC ( Site 0105) | Oceanside | California | 92056 | Recruiting |
| Kaiser Permanente - Roseville ( Site 0081) | Roseville | California | 95661 | Recruiting |
| Kaiser Permanente - San Francisco ( Site 0080) | San Francisco | California | 94115 | Recruiting |
| Kaiser Permanente - Santa Clara ( Site 0082) | Santa Clara | California | 95051 | Recruiting |
| Providence Medical Foundation ( Site 9543) | Santa Rosa | California | 95403 | Recruiting |
| Kaiser Permanente Vallejo Medical Center ( Site 0060) | Vallejo | California | 94589 | Recruiting |
| Kaiser Permanente - Walnut Creek ( Site 0078) | Walnut Creek | California | 94596 | Recruiting |
| Bass Medical Group ( Site 0089) | Walnut Creek | California | 94598 | Completed |
| Cancer Centers of Colorado St. Mary's Regional Hospital ( Site 0046) | Grand Junction | Colorado | 81501 | Recruiting |
| Yale Cancer Center ( Site 0053) | New Haven | Connecticut | 06510 | Recruiting |
| AdventHealth Altamonte Springs ( Site 0125) | Altamonte Springs | Florida | 32701 | Recruiting |
| Orlando Health Cancer Institute ( Site 0030) | Orlando | Florida | 32806 | Recruiting |
| Comprehensive Hematology Oncology ( Site 0091) | St. Petersburg | Florida | 33709 | Recruiting |
| Cleveland Clinic Martin North Hospital ( Site 0114) | Stuart | Florida | 34994 | Recruiting |
| Archbold Memorial Hospital-Lewis Hall Singletary Oncology Center ( Site 0040) | Thomasville | Georgia | 31792 | Completed |
| Illinois Cancer Specialists (ICS) ( Site 8010) | Arlington Heights | Illinois | 60005 | Recruiting |
| Orchard Healthcare Research Inc. ( Site 0014) | Skokie | Illinois | 60077 | Recruiting |
| Northwest Cancer Center - Dyer Clinic ( Site 0097) | Dyer | Indiana | 46311 | Recruiting |
| Parkview Research Center at Parkview Regional Medical Center ( Site 0011) | Fort Wayne | Indiana | 46845 | Recruiting |
| Cancer Center of Kansas ( Site 0004) | Wichita | Kansas | 67214 | Completed |
| Saint Elizabeth Medical Center Edgewood-Cancer Care Center ( Site 0044) | Edgewood | Kentucky | 41017 | Recruiting |
| CHRISTUS St. Frances Cabrini Hospital Center for Cancer Care ( Site 0109) | Alexandria | Louisiana | 71301 | Recruiting |
| Ochsner LSU Health - Monroe Medical Center, Family Medicine Clinic ( Site 0063) | Monroe | Louisiana | 71202 | Recruiting |
| Louisiana State University Health Sciences Shreveport ( Site 0029) | Shreveport | Louisiana | 71103 | Recruiting |
| Holy Cross Hospital ( Site 0069) | Silver Spring | Maryland | 20910 | Recruiting |
| University of Michigan ( Site 0103) | Ann Arbor | Michigan | 48109 | Recruiting |
| Profound Research LLC ( Site 0074) | Royal Oak | Michigan | 48073 | Completed |
| Metro-Minnesota Community Clinical Oncology ( Site 0031) | Saint Louis Park | Minnesota | 55426 | Recruiting |
| The University of Mississippi Medical Center-Cancer Center and Research Institute ( Site 0043) | Jackson | Mississippi | 39213 | Recruiting |
| SSM Health Cancer Care - Fenton ( Site 0088) | Fenton | Missouri | 63026 | Completed |
| Lake Regional Hospital ( Site 0009) | Osage Beach | Missouri | 65065 | Recruiting |
| Siteman Cancer Center ( Site 0099) | St Louis | Missouri | 63108 | Recruiting |
| Optum Care Cancer Center ( Site 9535) | Las Vegas | Nevada | 89102 | Recruiting |
| New Mexico Oncology Hematology Consultants Ltd. ( Site 0090) | Albuquerque | New Mexico | 87109 | Recruiting |
| CHRISTUS St. Vincent Regional Cancer Center ( Site 0118) | Santa Fe | New Mexico | 87505 | Recruiting |
| Memorial Sloan Kettering Cancer Center ( Site 0067) | New York | New York | 10065 | Recruiting |
| Clinical Research Alliance ( Site 0086) | Westbury | New York | 11590 | Recruiting |
| Levine Cancer Institute ( Site 0083) | Charlotte | North Carolina | 28204 | Recruiting |
| Sanford Cancer Center Bismarck ( Site 0058) | Bismarck | North Dakota | 58501 | Recruiting |
| Sanford Fargo Medical Center-Roger Maris Cancer Center ( Site 0056) | Fargo | North Dakota | 58102 | Recruiting |
| Altru Cancer Center ( Site 0104) | Grand Forks | North Dakota | 58201 | Recruiting |
| Cleveland Clinic - Mercy Hospital ( Site 0057) | Canton | Ohio | 44708 | Recruiting |
| Tri-County Hematology & Oncology Associates, Inc. ( Site 0076) | Massillon | Ohio | 44646 | Recruiting |
| Genesis Healthcare System ( Site 0025) | Zanesville | Ohio | 43701 | Recruiting |
| Hightower Clinical, LLC ( Site 0085) | Oklahoma City | Oklahoma | 73102 | Recruiting |
| Oklahoma Cancer Specialists and Research Institute, LLC ( Site 0041) | Tulsa | Oklahoma | 74146 | Recruiting |
| Providence Portland Medical Center ( Site 0116) | Portland | Oregon | 97213 | Recruiting |
| Providence Oncology and Hematology Care Clinic - Westside ( Site 0126) | Portland | Oregon | 97225 | Recruiting |
| Sidney Kimmel Cancer Center at Jefferson ( Site 0049) | Philadelphia | Pennsylvania | 19107 | Recruiting |
| Cancer Care Associates Of York ( Site 9517) | York | Pennsylvania | 17403 | Recruiting |
| Sanford Cancer Center ( Site 0059) | Sioux Falls | South Dakota | 57104 | Recruiting |
| West Cancer Center and Research Institute ( Site 0084) | Germantown | Tennessee | 38138 | Recruiting |
| Baptist Cancer Center ( Site 0101) | Memphis | Tennessee | 38120 | Recruiting |
| One Oncology - Tennessee Oncology ( Site 0098) | Nashville | Tennessee | 37203 | Recruiting |
| SCRI Oncology Partners ( Site 7000) | Nashville | Tennessee | 37203 | Recruiting |
| Tennessee Oncology ( Site 0111) | Nashville | Tennessee | 37203 | Recruiting |
| Nashville General Hospital ( Site 0072) | Nashville | Tennessee | 37208 | Completed |
| Vanderbilt Health One Hundred Oaks ( Site 0042) | Nashville | Tennessee | 37212 | Recruiting |
| Hendrick Medical Center ( Site 0117) | Abilene | Texas | 79601 | Recruiting |
| Harrington Cancer Center ( Site 0061) | Amarillo | Texas | 79106 | Recruiting |
| Texas Oncology - DFW ( Site 8000) | Dallas | Texas | 75246 | Recruiting |
| Parkland Health & Hospital System ( Site 0096) | Dallas | Texas | 75390 | Recruiting |
| University of Texas Southwestern Medical Center ( Site 0032) | Dallas | Texas | 75390 | Recruiting |
| Texas Oncology - Northeast Texas ( Site 8005) | Flower Mound | Texas | 75028 | Recruiting |
| John Peter Smith Hospital ( Site 0106) | Fort Worth | Texas | 76104 | Recruiting |
| Oncology Consultants P.A. ( Site 0107) | Houston | Texas | 77030 | Recruiting |
| Laguna Clinical Research Associates LLC ( Site 0068) | Laredo | Texas | 78041 | Recruiting |
| Mays Cancer Center ( Site 0122) | San Antonio | Texas | 78229 | Recruiting |
| The University of Texas Health Science Center at Tyler dba UT Health East Texas HOPE Cancer Center ( Site 0055) | Tyler | Texas | 75701 | Recruiting |
| Texas Oncology - Gulf Coast ( Site 8009) | Webster | Texas | 77598 | Recruiting |
| Intermountain Medical Center ( Site 0113) | Murray | Utah | 84107 | Recruiting |
| Hematology Oncology Associates of Fredericksburg ( Site 9550) | Fredericksburg | Virginia | 22408 | Recruiting |
| Bon Secours Memorial Regional Medical Center-Oncology Research Department ( Site 0020) | Midlothian | Virginia | 23114 | Recruiting |
| Virginia Cancer Institute ( Site 0034) | Richmond | Virginia | 23229 | Recruiting |
| Northwest Medical Specialties, PLLC ( Site 0093) | Tacoma | Washington | 98405 | Recruiting |
| SSM Health Dean Medical Group ( Site 0087) | Madison | Wisconsin | 53715 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 206 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06393374, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 30, 2026 · Synced May 6, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06393374 live on ClinicalTrials.gov.