A Phase 2 Trial of ALN-APP in Patients With Cerebral Amyloid Angiopathy
Public ClinicalTrials.gov record NCT06393712. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacodynamics of Intrathecally Administered ALN-APP in Patients With Cerebral Amyloid Angiopathy (CAA)
Study identification
- NCT ID
- NCT06393712
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Alnylam Pharmaceuticals
- Industry
- Enrollment
- 200 participants
Conditions and interventions
Conditions
Interventions
- ALN-APP Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 30 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 16, 2024
- Primary completion
- Aug 8, 2027
- Completion
- Dec 13, 2029
- Last update posted
- Apr 23, 2026
2024 – 2029
United States locations
- U.S. sites
- 34
- U.S. states
- 17
- U.S. cities
- 30
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Clinical Trial Site | Los Angeles | California | 90095 | Active, not recruiting |
| Clinical Trial Site | Orange | California | 92868 | Active, not recruiting |
| Clinical Trial Site | Palo Alto | California | 94304 | Active, not recruiting |
| Clinical Trial Site | Sacramento | California | 95816 | Active, not recruiting |
| Clinical Trial Site | San Francisco | California | 94114 | Active, not recruiting |
| Clinical Trial Site | Aurora | Colorado | 80045 | Active, not recruiting |
| Clinical Trial Site | New Haven | Connecticut | 06510 | Active, not recruiting |
| Clinical Trial Site | Gainesville | Florida | 32608 | Active, not recruiting |
| Clinical Trial Site | Jacksonville | Florida | 32224 | Active, not recruiting |
| Clinical Trial Site | Maitland | Florida | 32751 | Active, not recruiting |
| Clinical Trial Site | Naples | Florida | 34105 | Active, not recruiting |
| Clinical Trial Site | Chicago | Illinois | 60612 | Active, not recruiting |
| Clinical Trial Site | Lexington | Kentucky | 40504 | Active, not recruiting |
| Clinical Trial Site | New Orleans | Louisiana | 70121 | Active, not recruiting |
| Clinical Trial Site | Boston | Massachusetts | 02114 | Active, not recruiting |
| Clinical Trial Site | Plymouth | Massachusetts | 02360 | Active, not recruiting |
| Clinical Trial Site | Rochester | Minnesota | 55905 | Active, not recruiting |
| Clinical Trial Site | St Louis | Missouri | 63110 | Active, not recruiting |
| Clinical Trial Site | Hackensack | New Jersey | 07601 | Active, not recruiting |
| Clinical Trial Site | New York | New York | 10016 | Active, not recruiting |
| Clinical Trial Site | New York | New York | 10029 | Active, not recruiting |
| Clinical Trial Site | New York | New York | 10032 | Active, not recruiting |
| Clinical Trial Site | New York | New York | 10065 | Active, not recruiting |
| Clinical Trial Site | Durham | North Carolina | 27705 | Active, not recruiting |
| Clinical Trial Site | Canton | Ohio | 44718 | Active, not recruiting |
| Clinical Trial Site | Cleveland | Ohio | 44195 | Active, not recruiting |
| Clinical Trial Site | Abington | Pennsylvania | 19001 | Active, not recruiting |
| Clinical Trial Site | Philadelphia | Pennsylvania | 19104 | Active, not recruiting |
| Clinical Trial Site | Pittsburgh | Pennsylvania | 15213 | Active, not recruiting |
| Clinical Trial Site | Dallas | Texas | 75243 | Active, not recruiting |
| Clinical Trial Site | Dallas | Texas | 75390 | Active, not recruiting |
| Clinical Trial Site | Houston | Texas | 77030 | Active, not recruiting |
| Clinical Trial Site | San Antonio | Texas | 78229 | Active, not recruiting |
| Clinical Trial Site | Seattle | Washington | 98104 | Active, not recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 23 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06393712, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 23, 2026 · Synced Apr 27, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06393712 live on ClinicalTrials.gov.