Alzheimer's Plasma Extension
Public ClinicalTrials.gov record NCT06416072. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The goal of this observational study is to learn how Alzheimer's disease-related blood biomarkers, brain amyloid, and memory and thinking abilities change over time. The study will include up to 3,000 people who previously did not qualify for an anti-amyloid Alzheimer's disease prevention trial based on their amyloid eligibility. Participants may have previously screened for the AHEAD 3-45 Study, A4 Study, or another anti-amyloid Alzheimer's disease prevention trial. The main questions this study aims to answer are: * Can Alzheimer's disease-related blood tests help predict future buildup of amyloid in the brain? * How are changes in Alzheimer's disease-related blood biomarkers related to changes in brain amyloid, memory, thinking, and self-reported cognitive function? * Do these changes differ based on factors such as sex, APOE genetic status, race, ethnicity, socioeconomic status, or social factors? Participants will be followed for about 6 years. They will complete memory and thinking assessments and questionnaires and provide blood samples. Some participants may also be asked to take part in optional activities, including brain imaging with positron emission tomography (PET) or magnetic resonance imaging (MRI), digital cognitive assessments, and questionnaires about habits and social factors.
Study identification
- NCT ID
- NCT06416072
- Recruitment status
- Enrolling by invitation
- Study type
- Observational
- Phase
- Not listed
- Enrollment
- 3,000 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 55 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 21, 2023 (Actual)
- Primary completion
- Jun 2028 (Estimated)
- Completion
- Jun 2028 (Estimated)
- Last update posted
- Aug 18, 2026
2023 – 2028
United States locations
- U.S. sites
- 56
- U.S. states
- 30
- U.S. cities
- 51
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama, Birmingham | Birmingham | Alabama | 35233 | — |
| Banner Alzheimer's Institute | Phoenix | Arizona | 85006 | — |
| Banner Sun Health Research Institute | Sun City | Arizona | 85351 | — |
| University of California, Irvine | Irvine | California | 92697 | — |
| University of Southern California | Los Angeles | California | 90033 | — |
| Stanford University | Palo Alto | California | 94304 | — |
| Sharp Neurocognitive Research Center | San Diego | California | 92123 | — |
| University of California, San Francisco | San Francisco | California | 94158 | — |
| University of California, Davis | Walnut Creek | California | 94598 | — |
| Yale University School of Medicine | New Haven | Connecticut | 06510 | — |
| Georgetown University | Washington D.C. | District of Columbia | 20007 | — |
| Howard University | Washington D.C. | District of Columbia | 20060 | — |
| Brain Matters Research | Delray Beach | Florida | 33445 | — |
| Mayo Clinic, Jacksonville | Jacksonville | Florida | 32224 | — |
| K2 Medical Research - The Villages | Lady Lake | Florida | 32159 | — |
| K2 Medical Research, LLC | Maitland | Florida | 32751 | — |
| Gonzalez MD & Aswad MD Health Services | Miami | Florida | 33135 | — |
| Wien Center for Clinical Research | Miami Beach | Florida | 33140 | — |
| Charter Research | Orlando | Florida | 32803 | — |
| University of South Florida - Health Byrd Alzheimer Institute | Tampa | Florida | 33613 | — |
| Emory University | Atlanta | Georgia | 30322 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| Indiana University | Indianapolis | Indiana | 46202 | — |
| University of Kansas | Fairway | Kansas | 66205 | — |
| University of Kentucky | Lexington | Kentucky | 40504 | — |
| Johns Hopkins University | Baltimore | Maryland | 21224 | — |
| Boston University | Boston | Massachusetts | 02215 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 21155 | — |
| Headlands Eastern MA LLC | Plymouth | Massachusetts | 02360 | — |
| University of Michigan, Ann Arbor | Ann Arbor | Michigan | 48105 | — |
| Mayo Clinic, Rochester | Rochester | Minnesota | 55905 | — |
| Washington University, St. Louis | St Louis | Missouri | 63108 | — |
| Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas | Las Vegas | Nevada | 89101 | — |
| Mount Sinai School of Medicine | New York | New York | 10029 | — |
| Columbia University | New York | New York | 10032 | — |
| University of Rochester Medical Center | Rochester | New York | 14620 | — |
| Wake Forest University Health Sciences | Winston-Salem | North Carolina | 27157 | — |
| Case Western Reserve University | Beachwood | Ohio | 44122 | — |
| Cleveland Clinic Lou Ruvo Center for Brain Health, Ohio | Cleveland | Ohio | 44195 | — |
| Ohio State University | Columbus | Ohio | 43210 | — |
| Central States Research, LLC | Tulsa | Oklahoma | 74136 | — |
| Oregon Health & Science University | Portland | Oregon | 97239 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| University of Pittsburgh | Pittsburgh | Pennsylvania | 15213 | — |
| Butler Hospital Memory and Aging Program | Providence | Rhode Island | 02906 | — |
| Ralph H. Johnson VA Health Care System | Charleston | South Carolina | 29401 | — |
| Vanderbilt University Medical Center Center for Cognitive Medicine | Nashville | Tennessee | 37212 | — |
| University of Texas, Southwestern MC at Dallas | Dallas | Texas | 75390 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| Houston Methodist Neurological Institute | Houston | Texas | 77030 | — |
| University of Texas Health Science Center at San Antonio | San Antonio | Texas | 78229 | — |
| Eastern Virginia Medical School at Old Dominion University | Norfolk | Virginia | 23510 | — |
| National Clinical Research Inc. | Richmond | Virginia | 23294 | — |
| University of Washington, Memory and Brain Wellness Center | Seattle | Washington | 98195 | — |
| University of Wisconsin | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06416072, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 18, 2026 · Synced Oct 18, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06416072 live on ClinicalTrials.gov.