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Recruiting Phase 3 Interventional

A Study to Investigate the Efficacy and Safety of Dato-DXd With or Without Osimertinib Compared With Platinum Based Doublet Chemotherapy in Participants With EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer

ClinicalTrials.gov ID: NCT06417814

Public ClinicalTrials.gov record NCT06417814. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 5, 2026, 9:13 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase III, Open-label, Sponsor-blind, Randomized Study of Dato-DXd With or Without Osimertinib Versus Platinum-based Doublet Chemotherapy for Participants With EGFR-mutated Locally Advanced or Metastatic Non-small Cell Lung Cancer Whose Disease Has Progressed on Prior Osimertinib Treatment (TROPION-Lung15)

Study identification

NCT ID
NCT06417814
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
AstraZeneca
Industry
Enrollment
744 participants

Conditions and interventions

Interventions

  • Carboplatin Drug
  • Cisplatin Drug
  • Dato-DXd Drug
  • Osimertinib Drug
  • Pemetrexed Drug

Drug

Eligibility (public fields only)

Age range
18 Years to 130 Years
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Oct 3, 2024
Primary completion
Sep 29, 2026
Completion
Sep 26, 2028
Last update posted
Mar 1, 2026

2024 – 2028

United States locations

U.S. sites
33
U.S. states
19
U.S. cities
31
Facility City State ZIP Site status
Research Site Fayetteville Arkansas 72703 Recruiting
Research Site Duarte California 91010 Withdrawn
Research Site Fountain Valley California 92708 Recruiting
Research Site La Jolla California 92093 Recruiting
Research Site Los Angeles California 90048 Withdrawn
Research Site San Diego California 92123 Not yet recruiting
Research Site Colorado Springs Colorado 80909 Recruiting
Research Site Fort Collins Colorado 80528 Recruiting
Research Site Gainesville Florida 32608 Withdrawn
Research Site Jacksonville Florida 32256 Recruiting
Research Site Athens Georgia 30607 Recruiting
Research Site Chicago Illinois 60611 Not yet recruiting
Research Site Evanston Illinois 60201 Recruiting
Research Site Louisville Kentucky 40207 Recruiting
Research Site Baltimore Maryland 21201 Recruiting
Research Site Bethesda Maryland 20817 Recruiting
Research Site Boston Massachusetts 02114 Withdrawn
Research Site Boston Massachusetts 02215 Not yet recruiting
Research Site Detroit Michigan 48202 Recruiting
Research Site Kansas City Missouri 64132 Recruiting
Research Site Omaha Nebraska 68124 Recruiting
Research Site Morristown New Jersey 07960 Recruiting
Research Site Northfield New Jersey 08225 Recruiting
Research Site New York New York 10016 Withdrawn
Research Site New York New York 10065 Recruiting
Research Site The Bronx New York 10461 Recruiting
Research Site Maumee Ohio 43537 Recruiting
Research Site Philadelphia Pennsylvania 19107 Withdrawn
Research Site Pittsburgh Pennsylvania 15232 Recruiting
Research Site Chattanooga Tennessee 37404 Recruiting
Research Site Nashville Tennessee 37203 Recruiting
Research Site Fairfax Virginia 22031 Recruiting
Research Site Seattle Washington 98104 Withdrawn

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 266 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT06417814, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Mar 1, 2026 · Synced May 5, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06417814 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →