ClinicalTrials.gov record
A Study to Evaluate the Efficacy and Safety of Pegozafermin in Participants With Compensated Cirrhosis Due to MASH
ClinicalTrials.gov ID: NCT06419374
Public ClinicalTrials.gov record NCT06419374. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 8, 2026, 3:55 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3 Study to Evaluate the Efficacy and Safety of Pegozafermin in Subjects With Compensated Cirrhosis Due to Metabolic Dysfunction-Associated Steatohepatitis (MASH) (ENLIGHTEN-Cirrhosis)
Study identification
- NCT ID
- NCT06419374
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- 89bio, Inc.
- Industry
- Enrollment
- 762 participants
Conditions and interventions
Interventions
- Pegozafermin Biological
- Placebo Drug
Biological · Drug
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 23, 2024
- Primary completion
- May 31, 2028
- Completion
- Jul 31, 2031
- Last update posted
- May 5, 2026
2024 – 2031
United States locations
- U.S. sites
- 135
- U.S. states
- 33
- U.S. cities
- 115
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| 89bio Clinical Study Site | Birmingham | Alabama | 35205 | Recruiting |
| 89bio Clinical Study Site | Homewood | Alabama | 35209 | Recruiting |
| 89bio Clinical Study Site | Chandler | Arizona | 85224 | Recruiting |
| 89bio Clinical Study Site | Flagstaff | Arizona | 86001 | Withdrawn |
| 89bio Clinical Study Site | Peoria | Arizona | 85381 | Recruiting |
| 89bio Clinical Study Site | Phoenix | Arizona | 85054 | Recruiting |
| 89bio Clinical Study Site | Tucson | Arizona | 85712 | Recruiting |
| 89bio Clinical Study Site | Tucson | Arizona | 85715 | Recruiting |
| 89bio Clinical Study Site | Tucson | Arizona | 85716 | Recruiting |
| 89bio Clinical Study Site | Little Rock | Arkansas | 72205 | Recruiting |
| 89bio Clinical Study Site | North Little Rock | Arkansas | 72117 | Recruiting |
| 89bio Clinical Study Site | Camarillo | California | 93012 | Recruiting |
| 89bio Clinical Study Site | Canoga Park | California | 91304 | Recruiting |
| 89bio Clinical Study Site | Coronado | California | 92118 | Recruiting |
| 89bio Clinical Study Site | Fountain Valley | California | 92708 | Recruiting |
| 89bio Clinical Study Site | Fresno | California | 93720 | Recruiting |
| 89bio Clinical Study Site | Huntington Park | California | 90255 | Withdrawn |
| 89bio Clinical Study Site | La Jolla | California | 92037-0887 | Recruiting |
| 89bio Clinical Study Site | Los Angeles | California | 90033 | Recruiting |
| 89bio Clinical Study Site | Los Angeles | California | 90048 | Recruiting |
| 89bio Clinical Study Site | Pasadena | California | 91105 | Recruiting |
| 89bio Clinical Study Site | Poway | California | 92064 | Recruiting |
| 89bio Clinical Study Site | Redwood City | California | 94063 | Recruiting |
| 89bio Clinical Study Site | Rialto | California | 92377 | Recruiting |
| 89bio Clinical Study Site | Sacramento | California | 95817 | Recruiting |
| 89bio Clinical Study Site | Santa Ana | California | 92704 | Withdrawn |
| 89bio Clinical Study Site | Littleton | Colorado | 80120 | Recruiting |
| 89bio Clinical Study Site | Clermont | Florida | 34711 | Recruiting |
| 89bio Clinical Study Site | Fort Myers | Florida | 33912 | Recruiting |
| 89bio Clinical Study Site | Gainesville | Florida | 32610 | Recruiting |
| 89bio Clinical Study Site | Hialeah Gardens | Florida | 33016 | Recruiting |
| 89bio Clinical Study Site | Homestead | Florida | 33030 | Recruiting |
| 89bio Clinical Study Site | Jacksonville | Florida | 32224 | Recruiting |
| 89bio Clinical Study Site | Jacksonville | Florida | 32256 | Recruiting |
| 89bio Clinical Study Site | Lady Lake | Florida | 32159 | Withdrawn |
| 89bio Clinical Study Site | Lakewood Rch | Florida | 34211 | Recruiting |
| 89bio Clinical Study Site | Lehigh Acres | Florida | 33936 | Recruiting |
| 89bio Clinical Study Site | Maitland | Florida | 32751 | Recruiting |
| 89bio Clinical Study Site | Miami | Florida | 33144 | Recruiting |
| 89bio Clinical Study Site | Miami | Florida | 33176-1530 | Recruiting |
| 89bio Clinical Study Site | Miami | Florida | 33176-7947 | Recruiting |
| 89bio Clinical Study Site | New Port Richey | Florida | 34653 | Recruiting |
| 89bio Clinical Study Site | Ocala | Florida | 34471 | Recruiting |
| 89bio Clinical Study Site | Ocoee | Florida | 34761 | Recruiting |
| 89bio Clinical Study Site | Orlando | Florida | 32825 | Withdrawn |
| 89bio Clinical Study Site | University Park | Florida | 34201 | Recruiting |
| 89bio Clinical Study Site | Viera | Florida | 32940 | Recruiting |
| 89bio Clinical Study Site | Winter Park | Florida | 32789 | Recruiting |
| 89bio Clinical Study Site | Athens | Georgia | 30607 | Recruiting |
| 89bio Clinical Study Site | Atlanta | Georgia | 30309 | Recruiting |
| 89bio Clinical Study Site | Chicago | Illinois | 60611 | Recruiting |
| 89bio Clinical Study Site | Hammond | Indiana | 46324 | Recruiting |
| 89bio Clinical Study Site | New Albany | Indiana | 47150 | Recruiting |
| 89bio Clinical Study Site | South Bend | Indiana | 46635 | Recruiting |
| 89bio Clinical Study Site | Iowa City | Iowa | 52242 | Recruiting |
| 89bio Clinical Study Site | Kansas City | Kansas | 66160 | Recruiting |
| 89bio Clinical Study Site | Topeka | Kansas | 66606 | Recruiting |
| 89bio Clinical Study Site | Lafayette | Louisiana | 70503 | Recruiting |
| 89bio Clinical Study Site | Lake Charles | Louisiana | 70605 | Recruiting |
| 89bio Clinical Study Site | West Monroe | Louisiana | 71291 | Recruiting |
| 89bio Clinical Study Site | Baltimore | Maryland | 21202 | Recruiting |
| 89bio Clinical Study Site | Glen Burnie | Maryland | 21061 | Recruiting |
| 89bio Clinical Study Site | Greenbelt | Maryland | 20770 | Recruiting |
| 89bio Clinical Study Site | Burlington | Massachusetts | 01805 | Recruiting |
| 89bio Clinical Study Site | Ann Arbor | Michigan | 48109 | Recruiting |
| 89bio Clinical Study Site | Clinton Township | Michigan | 48038 | Recruiting |
| 89bio Clinical Study Site | Detroit | Michigan | 48202 | Recruiting |
| 89bio Clinical Study Site | Wyoming | Michigan | 49519 | Recruiting |
| 89bio Clinical Study Site | Ypsilanti | Michigan | 48197 | Recruiting |
| 89bio Clinical Study Site | Minneapolis | Minnesota | 55413 | Recruiting |
| 89bio Clinical Study Site | Rochester | Minnesota | 55905 | Recruiting |
| 89bio Clinical Study Site | Flowood | Mississippi | 39232 | Recruiting |
| 89bio Clinical Study Site | Tupelo | Mississippi | 38801 | Withdrawn |
| 89bio Clinical Study Site | St Louis | Missouri | 63110 | Recruiting |
| 89bio Clinical Study Site | St Louis | Missouri | 63123 | Recruiting |
| 89bio Clinical Study Site | Las Vegas | Nevada | 89106 | Recruiting |
| 89bio Clinical Study Site | Florham Park | New Jersey | 07932 | Withdrawn |
| 89bio Clinical Study Site | Somers Point | New Jersey | 08244 | Recruiting |
| 89bio Clinical Study Site | Albuquerque | New Mexico | 87109 | Recruiting |
| 89bio Clinical Study Site | New York | New York | 10016 | Recruiting |
| 89bio Clinical Study Site | New York | New York | 10021 | Recruiting |
| 89bio Clinical Study Site | New York | New York | 10033 | Withdrawn |
| 89bio Clinical Study Site | Asheville | North Carolina | 28801 | Recruiting |
| 89bio Clinical Study Site | Charlotte | North Carolina | 28207 | Recruiting |
| 89bio Clinical Study Site | Durham | North Carolina | 27710 | Recruiting |
| 89bio Clinical Study Site | Fayetteville | North Carolina | 28304 | Recruiting |
| 89bio Clinical Study Site | Greenville | North Carolina | 27834 | Recruiting |
| 89bio Clinical Study Site | Winston-Salem | North Carolina | 27103 | Recruiting |
| 89bio Clinical Study Site | Akron | Ohio | 44320 | Recruiting |
| 89bio Clinical Study Site | Cincinnati | Ohio | 45267 | Recruiting |
| 89bio Clinical Study Site | Cleveland | Ohio | 44106 | Recruiting |
| 89bio Clinical Study Site | Columbus | Ohio | 43210 | Recruiting |
| 89bio Clinical Study Site | Dayton | Ohio | 45414 | Recruiting |
| 89bio Clinical Study Site | Liberty Township | Ohio | 45044 | Recruiting |
| 89bio Clinical Study Site | Westlake | Ohio | 44145 | Recruiting |
| 89bio Clinical Study Site | Philadelphia | Pennsylvania | 19148 | Recruiting |
| 89bio Clinical Study Site | Pittsburgh | Pennsylvania | 15213 | Recruiting |
| 89bio Clinical Study Site | East Greenwich | Rhode Island | 02818 | Recruiting |
| 89bio Clinical Study Site | Charleston | South Carolina | 29425 | Recruiting |
| 89bio Clinical Study Site | Columbia | South Carolina | 29204 | Recruiting |
| 89bio Clinical Study Site | Rapid City | South Dakota | 57701 | Recruiting |
| 89bio Clinical Study Site | Cordova | Tennessee | 38018 | Recruiting |
| 89bio Clinical Study Site | Hermitage | Tennessee | 37076 | Recruiting |
| 89bio Clinical Study Site | Nashville | Tennessee | 37211 | Recruiting |
| 89bio Clinical Study Site | Amarillo | Texas | 79106 | Recruiting |
| 89bio Clinical Study Site | Austin | Texas | 78745 | Recruiting |
| 89bio Clinical Study Site | Austin | Texas | 78757-8059 | Recruiting |
| 89bio Clinical Study Site | Austin | Texas | 78757-8066 | Recruiting |
| 89bio Clinical Study Site | Brownsville | Texas | 78520 | Recruiting |
| 89bio Clinical Study Site | DeSoto | Texas | 75115 | Recruiting |
| 89bio Clinical Study Site | Edinburg | Texas | 78539 | Withdrawn |
| 89bio Clinical Study Site | Farmers Branch | Texas | 75234 | Recruiting |
| 89bio Clinical Study Site | Fort Worth | Texas | 76104 | Recruiting |
| 89bio Clinical Study Site | Harlingen | Texas | 78550 | Recruiting |
| 89bio Clinical Study Site | Houston | Texas | 77030 | Recruiting |
| 89bio Clinical Study Site | Houston | Texas | 77074 | Recruiting |
| 89bio Clinical Study Site | Houston | Texas | 77099 | Recruiting |
| 89bio Clinical Study Site | Lewisville | Texas | 75067 | Recruiting |
| 89bio Clinical Study Site | Lubbock | Texas | 79410 | Recruiting |
| 89bio Clinical Study Site | Mansfield | Texas | 76063 | Recruiting |
| 89bio Clinical Study Site | Pearland | Texas | 77584 | Recruiting |
| 89bio Clinical Study Site | San Antonio | Texas | 78209 | Recruiting |
| 89bio Clinical Study Site | San Antonio | Texas | 78229-4801 | Recruiting |
| 89bio Clinical Study Site | San Antonio | Texas | 78229-5069 | Recruiting |
| 89bio Clinical Study Site | San Marcos | Texas | 78666 | Recruiting |
| 89bio Clinical Study Site | Waco | Texas | 76710 | Recruiting |
| 89bio Clinical Study Site | Waco | Texas | 76712 | Recruiting |
| 89bio Clinical Study Site | Sandy City | Utah | 84092 | Recruiting |
| 89bio Clinical Study Site | West Jordan | Utah | 84088 | Recruiting |
| 89bio Clinical Study Site | Richmond | Virginia | 23226 | Recruiting |
| 89bio Clinical Study Site | Richmond | Virginia | 23229 | Withdrawn |
| 89bio Clinical Study Site | Richmond | Virginia | 23236 | Recruiting |
| 89bio Clinical Study Site | Richmond | Virginia | 23298 | Recruiting |
| 89bio Clinical Study Site | Seattle | Washington | 98101 | Recruiting |
| 89bio Clinical Study Site | Seattle | Washington | 98105 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 161 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06419374, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 5, 2026 · Synced May 8, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06419374 live on ClinicalTrials.gov.