Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
Public ClinicalTrials.gov record NCT06423430. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Treatment ResistAnt Depression Subcallosal CingulatE Network DBS
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The goal of this clinical trial is to evaluate the effectiveness and safety of bilateral stimulation of the subcallosal cingulate white matter (SCCwm) using Deep Brain Stimulation (DBS) as an adjunctive treatment of non-psychotic unipolar Major Depressive Disorder (MDD) in adults.
Study identification
- NCT ID
- NCT06423430
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 100 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 22 Years to 70 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 10, 2024
- Primary completion
- Mar 31, 2027
- Completion
- Mar 31, 2029
- Last update posted
- Aug 27, 2026
2024 – 2029
United States locations
- U.S. sites
- 25
- U.S. states
- 17
- U.S. cities
- 22
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham - Dept. of Psychiatry | Birmingham | Alabama | 35294 | Recruiting |
| USC University Hospital | Los Angeles | California | 90033 | Not yet recruiting |
| UCLA Department of Psychiatry | Los Angeles | California | 90095 | Recruiting |
| University of California at Davis | Sacramento | California | 95817 | Recruiting |
| USF Health | Tampa | Florida | 33613 | Recruiting |
| Emory University Hospital | Atlanta | Georgia | 30322 | Recruiting |
| Rush University Medical Center | Chicago | Illinois | 60612 | Recruiting |
| Indiana University | Indianapolis | Indiana | 46202 | Recruiting |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | Recruiting |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | Recruiting |
| University of Minnesota Medical Center Fairview | Minneapolis | Minnesota | 55455 | Not yet recruiting |
| Mayo Clinic | Rochester | Minnesota | 55905 | Recruiting |
| Washington University School of Medicine | St Louis | Missouri | 63110 | Recruiting |
| Robert Wood Johnson University Hospital | New Brunswick | New Jersey | 08901 | Recruiting |
| Mount Sinai Hospital | New York | New York | 10019 | Recruiting |
| The Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | Recruiting |
| The Ohio State University | Columbus | Ohio | 43210 | Recruiting |
| Pennsylvania Hospital | Philadelphia | Pennsylvania | 19107 | Recruiting |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | Recruiting |
| University of Texas Austin Dell Medical School | Austin | Texas | 78701 | Recruiting |
| University of Texas Southwestern Medical Center at Dallas | Dallas | Texas | 75390 | Recruiting |
| CHI St. Luke's Health Baylor College of Medicine Med. Ctr | Houston | Texas | 77030 | Recruiting |
| The Methodist Hospital | Houston | Texas | 77030 | Recruiting |
| University of Utah Hospital | Salt Lake City | Utah | 84132 | Recruiting |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06423430, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 27, 2026 · Synced Sep 2, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06423430 live on ClinicalTrials.gov.