Study of Olverembatinib (HQP1351) in Patients With CML-CP
Public ClinicalTrials.gov record NCT06423911. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Global, Multicenter, Open Label, Randomized, Phase 3 Registrational Study of Olverembatinib (HQP1351) in Patients With Chronic Phase Chronic Myeloid Leukemia (CML-CP)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Study comparing efficacy and safety of olverembatinib (investigational arm) vs. bosutinib (control arm) in patients with CML-CP (Part A). Study will also evaluate efficacy and safety of olverembatinib (single-arm) in CML-CP patients with T315I mutation (Part B). Patients who meet ELN 2025 failure criteria while receiving bosutinib in Part A may be able to receive olverembatinib in crossover follow-on study.
Study identification
- NCT ID
- NCT06423911
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 333 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 5, 2024 (Actual)
- Primary completion
- Jun 30, 2027 (Estimated)
- Completion
- Jul 10, 2028 (Estimated)
- Last update posted
- Sep 15, 2026
2024 – 2028
United States locations
- U.S. sites
- 50
- U.S. states
- 25
- U.S. cities
- 47
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Ascentage Investigative Site #1044 | Birmingham | Alabama | 35249 | Recruiting |
| Ascentage Investigative Site #1112 | Anchorage | Alaska | 99508 | Recruiting |
| Ascentage Investigative Site #1111 | Goodyear | Arizona | 85338 | Recruiting |
| Ascentage Investigative Site #1062 | Duarte | California | 91010 | Recruiting |
| Ascentage Investigative Site #1099 | Irvine | California | 92618 | Recruiting |
| Ascentage Investigative Site #1075 | La Jolla | California | 92037 | Recruiting |
| Ascentage Investigative Site #1100 | Long Beach | California | 90813 | Recruiting |
| Ascentage Investigative Site #1059 | Los Angeles | California | 90024 | Recruiting |
| Ascentage Investigative Site #1121 | Sacramento | California | 95817 | Recruiting |
| Ascentage Investigative Site #1109 | Upland | California | 91786 | Recruiting |
| Ascentage Investigative Site #1045 | Augusta | Georgia | 30912 | Recruiting |
| Ascentage Investigative Site #1110 | Newnan | Georgia | 30265 | Recruiting |
| Ascentage Investigative Site #1055 | Chicago | Illinois | 60637 | Recruiting |
| Ascentage Investigative Site #1095 | Decatur | Illinois | 62526 | Recruiting |
| Ascentage Investigative Site #1069 | Indianapolis | Indiana | 46237 | Recruiting |
| Ascentage Investigative Site #1065 | Wichita | Kansas | 67214 | Recruiting |
| Ascentage Investigative Site #1084 | Lexington | Kentucky | 40536 | Recruiting |
| Ascentage Investigative Site #1058 | Louisville | Kentucky | 40202 | Recruiting |
| Ascentage Investigative Site #1801 | Baltimore | Maryland | 21201 | Recruiting |
| Ascentage Investigative Site #1056 | Detroit | Michigan | 48201 | Recruiting |
| Ascentage Investigative Site #1023 | Detroit | Michigan | 49254 | Recruiting |
| Ascentage Investigative Site #1088 | St Louis | Missouri | 63108 | Recruiting |
| Ascentage Investigative Site #1097 | Lincoln | Nebraska | 68506 | Not yet recruiting |
| Ascentage Investigative Site #1066 | Las Vegas | Nevada | 89169 | Recruiting |
| Ascentage Investigative Site #1113 | Reno | Nevada | 89511 | Recruiting |
| Ascentage Investigative Site #1064 | Hackensack | New Jersey | 07601 | Recruiting |
| Ascentage Investigative Site #1054 | Morristown | New Jersey | 07960 | Recruiting |
| Ascentage Investigative Site #1098 | New Brunswick | New Jersey | 08901 | Recruiting |
| Ascentage Investigative Site #1072 | Albuquerque | New Mexico | 87102 | Recruiting |
| Ascentage Investigative Site #1068 | Rochester | New York | 14642 | Recruiting |
| Ascentage Investigative Site #1053 | Shirley | New York | 11967 | Recruiting |
| Ascentage Investigative Site #1160 | Stony Brook | New York | 11794 | Not yet recruiting |
| Ascentage Investigative Site #1019 | Greenville | North Carolina | 27858 | Not yet recruiting |
| Ascentage Investigative Site #1043 | Morrisville | North Carolina | 27560 | Recruiting |
| Ascentage Investigative Site #1173 | Cleveland | Ohio | 44111 | Not yet recruiting |
| Ascentage Investigative Site #1096 | Cleveland | Ohio | 44195 | Not yet recruiting |
| Ascentage Investigative Site #1174 | Mayfield Heights | Ohio | 44124 | Not yet recruiting |
| Ascentage Investigative Site #1139 | Portland | Oregon | 97239 | Not yet recruiting |
| Ascentage Investigative Site #1057 | Philadelphia | Pennsylvania | 19104 | Recruiting |
| Ascentage Investigative Site #1022 | Pittsburgh | Pennsylvania | 15232 | Recruiting |
| Ascentage Investigative Site #1063 | Chattanooga | Tennessee | 37404 | Recruiting |
| Ascentage Investigative Site #1089 | Nashville | Tennessee | 37203 | Recruiting |
| Ascentage Investigative Site #1051 | Amarillo | Texas | 79124 | Recruiting |
| Ascentage Investigative Site #1036 | Austin | Texas | 78705 | Recruiting |
| Ascentage Investigative Site #1501 | Houston | Texas | 77030 | Recruiting |
| Ascentage Investigative Site #1050 | Virginia Beach | Virginia | 23456 | Recruiting |
| Ascentage Investigative Site #1136 | Edmonds | Washington | 98026 | Recruiting |
| Ascentage Investigative Site #1135 | Issaquah | Washington | 98029 | Recruiting |
| Ascentage Investigative Site #1806 | Seattle | Washington | 98104 | Recruiting |
| Ascentage Investigative Site #1510 | Seattle | Washington | 98109 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 113 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06423911, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 15, 2026 · Synced Oct 17, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06423911 live on ClinicalTrials.gov.