A Study to Evaluate the Risk of Tumor Lysis Syndrome (TLS) in Adult Participants Receiving Oral Venetoclax in Combination With Intravenously Infused Obinutuzumab or Oral Acalabrutinib for Previously Untreated Chronic Lymphocytic Leukemia (CLL)
Public ClinicalTrials.gov record NCT06428019. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Prospective, Open-Label, Phase IIb/III Study to Evaluate the Risk of TLS and Optimization of the Initiation of Venetoclax in Combination With Obinutuzumab or Acalabrutinib With Different Ramp- Up Periods in Previously Untreated Subjects With CLL
Study identification
- NCT ID
- NCT06428019
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- AbbVie
- Industry
- Enrollment
- 170 participants
Conditions and interventions
Conditions
Interventions
- Acalabrutinib Drug
- Obinutuzumab Drug
- Venetoclax Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 4, 2024
- Primary completion
- Feb 29, 2028
- Completion
- Feb 29, 2028
- Last update posted
- Apr 8, 2026
2024 – 2028
United States locations
- U.S. sites
- 32
- U.S. states
- 23
- U.S. cities
- 31
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arizona Oncology - Tucson - Rudasill /ID# 267552 | Tucson | Arizona | 85704 | Recruiting |
| Southern VA Health Care System /ID# 266254 | Tucson | Arizona | 85723 | Recruiting |
| UCSF FRESNO/Community Cancer Institute /ID# 270874 | Clovis | California | 93611 | Recruiting |
| Valkyrie Clinical Trials /ID# 268151 | Los Angeles | California | 90067 | Recruiting |
| Rocky Mountain Cancer Centers - Aurora /ID# 267549 | Aurora | Colorado | 80012 | Recruiting |
| Yale University School of Medicine /ID# 266224 | New Haven | Connecticut | 06510 | Recruiting |
| Malcolm Randall V.A. Medical Center /ID# 267825 | Gainesville | Florida | 32608 | Recruiting |
| Cancer Specialists of North Florida - Jacksonville - AC Skinner Parkway /ID# 266713 | Jacksonville | Florida | 32256 | Recruiting |
| Mid Florida Hematology And Oncology Center /ID# 269159 | Orange City | Florida | 32763 | Recruiting |
| Comprehensive Hematology Oncology /ID# 267644 | St. Petersburg | Florida | 33709 | Recruiting |
| Springfield Clinic - First /ID# 270145 | Springfield | Illinois | 62702 | Recruiting |
| Northwest Cancer Center - Dyer Clinic /ID# 268478 | Dyer | Indiana | 46311 | Recruiting |
| University of Iowa Health Care /ID# 267206 | Des Moines | Iowa | 50314-3017 | Recruiting |
| Willis-Knighton Medical Center /ID# 270569 | Shreveport | Louisiana | 71103 | Completed |
| Center for Cancer and Blood Disorders-American Oncology Partners of Maryland /ID# 266445 | Bethesda | Maryland | 20817 | Recruiting |
| Maryland Oncology Hematology - Silver Spring /ID# 267557 | Silver Spring | Maryland | 20904 | Recruiting |
| UMass Memorial Medical Center /ID# 270023 | Worcester | Massachusetts | 01655 | Recruiting |
| Henry Ford Hospital /ID# 270973 | Detroit | Michigan | 48202 | Recruiting |
| Saint Lukes Hospital of Kansas City /ID# 267270 | Kansas City | Missouri | 64111 | Recruiting |
| Icahn School of Medicine at Mount Sinai /ID# 266328 | New York | New York | 10029 | Recruiting |
| Atrium Health /ID# 267219 | Charlotte | North Carolina | 28204-2963 | Recruiting |
| Atrium Health Wake Forest Baptist Medical Center /ID# 273142 | Winston-Salem | North Carolina | 27157 | Recruiting |
| Cleveland Clinic Main Campus /ID# 271292 | Cleveland | Ohio | 44195 | Recruiting |
| Oklahoma Cancer Specialists and Research Institute /ID# 267643 | Tulsa | Oklahoma | 74146 | Recruiting |
| Willamette Valley Cancer Institute and Research Center /ID# 266326 | Eugene | Oregon | 97401 | Recruiting |
| Lifespan Cancer Institute - Providence /ID# 266550 | Providence | Rhode Island | 02903 | Recruiting |
| Texas Oncology - Austin Midtown /ID# 268152 | Austin | Texas | 78705 | Recruiting |
| University of Texas - Southwestern Medical Center /ID# 266528 | Dallas | Texas | 75235 | Recruiting |
| Virginia Cancer Specialists - Fairfax /ID# 268155 | Fairfax | Virginia | 22031 | Recruiting |
| Vista Oncology - East Olympia /ID# 267337 | Olympia | Washington | 98506 | Recruiting |
| Northwest Medical Specialties Tacoma /ID# 266327 | Tacoma | Washington | 98405 | Recruiting |
| West Virginia University School of Medicine /ID# 267645 | Morgantown | West Virginia | 26506 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 38 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06428019, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 8, 2026 · Synced May 8, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06428019 live on ClinicalTrials.gov.