A Study Comparing the Efficacy and Safety of Zanidatamab to Trastuzumab, Each in Combination With Physician's Choice Chemotherapy, for the Treatment of Participants With Metastatic HER2-positive Breast Cancer
Public ClinicalTrials.gov record NCT06435429. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Open-label, Multicenter, Controlled Study to Evaluate the Efficacy and Safety of Zanidatamab in Combination With Physician's Choice Chemotherapy Compared to Trastuzumab in Combination With Physician's Choice Chemotherapy for the Treatment of Participants With Metastatic HER2-positive Breast Cancer Who Have Progressed on, or Are Intolerant to, Previous Trastuzumab Deruxtecan Treatment
Study identification
- NCT ID
- NCT06435429
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Jazz Pharmaceuticals
- Industry
- Enrollment
- 550 participants
Conditions and interventions
Conditions
Interventions
- Capecitabine Drug
- Eribulin Drug
- Gemcitabine Drug
- Trastuzumab Drug
- Vinorelbine Drug
- Zanidatamab Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 12, 2024
- Primary completion
- Apr 27, 2028
- Completion
- Oct 17, 2030
- Last update posted
- Feb 9, 2026
2024 – 2030
United States locations
- U.S. sites
- 48
- U.S. states
- 19
- U.S. cities
- 37
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Mayo Clinic Scottsdale - PPDS | Phoenix | Arizona | 85054 | Recruiting |
| Arizona Oncology Tucson - Wilmot | Tucson | Arizona | 85711 | Withdrawn |
| University of Arizona Cancer Center | Tucson | Arizona | 85719 | Recruiting |
| The Oncology Institute Of Hope And Innovation | Cerritos | California | 90703 | Recruiting |
| Los Angeles Hematology Oncology Medical Group Glendale | Glendale | California | 91204 | Recruiting |
| USC-Norris Comprehensive Cancer Center - Investigational Drug Service IDS | Los Angeles | California | 90033 | Recruiting |
| UCSF at Mission Bay MB | San Francisco | California | 94158 | Recruiting |
| University of Colorado-Cancer Center-PPDS | Aurora | Colorado | 80045-2517 | Recruiting |
| Rocky Mountain Cancer Centers | Denver | Colorado | 80218 | Recruiting |
| Medstar Georgetown University Hospital | Washington D.C. | District of Columbia | 20007 | Recruiting |
| Washington Cancer Center | Washington D.C. | District of Columbia | 20010 | Recruiting |
| Florida Cancer Specialists Research South | Fort Myers | Florida | 33901 | Recruiting |
| Mayo Clinic Jacksonville - PPDS | Jacksonville | Florida | 32224 | Recruiting |
| Florida Cancer Specialists Research North | St. Petersburg | Florida | 33705 | Recruiting |
| Florida Cancer Specialists Research East | West Palm Beach | Florida | 33401 | Recruiting |
| Dana Farber Cancer Institute | Boston | Massachusetts | 02215-5418 | Recruiting |
| Minnesota Oncology Hematology | Coon Rapids | Minnesota | 55433 | Recruiting |
| Mayo Clinic - PPDS | Rochester | Minnesota | 55905 | Recruiting |
| Saint Luke's Cancer Institute | Kansas City | Missouri | 64111 | Recruiting |
| Hackensack Meridian Health | Hackensack | New Jersey | 07601 | Recruiting |
| Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | 08901 | Recruiting |
| Memorial Sloan Kettering | Long Island City | New York | 11101 | Recruiting |
| Perlmutter Cancer Center 160 E 34th St | New York | New York | 10016-4744 | Recruiting |
| The Mount Sinai Hospital | New York | New York | 10029 | Recruiting |
| Columbia University Medical Center 161 Fort Washington | New York | New York | 10032-3729 | Recruiting |
| Messino Cancer Center | Asheville | North Carolina | 28806 | Recruiting |
| Duke Cancer Institute | Durham | North Carolina | 27710-2000 | Recruiting |
| UNC Central Investigational Drug Services | Morrisville | North Carolina | 27560 | Recruiting |
| Oncology Hematology Care (OHC) | Cincinnati | Ohio | 45226 | Recruiting |
| University Hospitals Cleveland Medical Center 11100 Euclid Ave | Cleveland | Ohio | 44106-1716 | Withdrawn |
| Abramson Cancer Center of The University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | Recruiting |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111 | Recruiting |
| Rhode Island Hospital | Providence | Rhode Island | 02903 | Recruiting |
| Sarah Cannon Research Institute | Nashville | Tennessee | 37203 | Recruiting |
| Texas Oncology - Fort Worth | Fort Worth | Texas | 76104 | Recruiting |
| U.T. MD Anderson Cancer Center, Investigational Pharmacy Services | Houston | Texas | 77030 | Recruiting |
| Millennium Research and Clinical Development | Houston | Texas | 77090 | Withdrawn |
| Maryland Oncology Hematology Healing Way - USOR | Irving | Texas | 75063 | Recruiting |
| Medical Oncology Hematology Consultants | Irving | Texas | 75063 | Recruiting |
| Nexus Health | Irving | Texas | 75063 | Recruiting |
| Sansum Clinic 540 W - USOR | Irving | Texas | 75063 | Recruiting |
| Texas Oncology Gulf Coast | Irving | Texas | 75063 | Recruiting |
| Texas Oncology West | Irving | Texas | 75063 | Recruiting |
| Virginia Cancer Specialists | Fairfax | Virginia | 22031 | Recruiting |
| Virginia Oncology Associates, Sentara Health | Norfolk | Virginia | 23502 | Recruiting |
| Blue Ridge Cancer Care | Roanoke | Virginia | 24014 | Recruiting |
| Fred Hutchinson Cancer Center | Seattle | Washington | 98109 | Recruiting |
| Froedtert and The Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 118 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06435429, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 9, 2026 · Synced May 10, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06435429 live on ClinicalTrials.gov.