A Study to Learn About the Study Medicine Aztreonam-Avibactam (ATM-AVI) in Infants and Newborns Admitted in Hospitals With Bacterial Infection (CHERISH)

ClinicalTrials.gov ID: NCT06462235

Public ClinicalTrials.gov record NCT06462235. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 6, 2026, 8:39 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A PHASE 2A, 2-PART, OPEN-LABEL, NON-RANDOMIZED, MULTICENTER, SINGLE AND MULTIPLE DOSE TRIAL TO EVALUATE PHARMACOKINETICS, SAFETY AND TOLERABILITY OF AZTREONAM AND AVIBACTAM ± METRONIDAZOLE IN NEONATES AND INFANTS FROM BIRTH TO LESS THAN 9 MONTHS OF AGE WITH SUSPECTED OR CONFIRMED INFECTIONS DUE TO GRAM-NEGATIVE PATHOGENS REQUIRING INTRAVENOUS ANTIBIOTIC TREATMENT

Study identification

NCT ID: NCT06462235
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: Pfizer; Industry
Enrollment: 48 participants

Conditions and interventions

Conditions

Gram-negative Bacterial Infection

Interventions

Part A: ATM-AVI Single Dose, Cohorts 1-4 Drug
Part B: Multiple-dose ATM-AVI, Cohorts 1-4 Drug

Drug

Eligibility (public fields only)

Age range: Up to 39 Weeks
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Sep 24, 2024
Primary completion: Apr 24, 2027
Completion: Apr 24, 2027
Last update posted: May 4, 2026

2024 – 2027

United States locations

U.S. sites: 13
U.S. states: 8
U.S. cities: 8

Facility	City	State	ZIP	Site status
Children's Hospital of Orange County Southwest Tower	Orange	California	92868	Recruiting
Children's Hospital of Orange County	Orange	California	92868	Recruiting
Children's Hospital Colorado	Aurora	Colorado	80045	Recruiting
Riley Hospital for Children at Indiana University Health	Indianapolis	Indiana	46202	Recruiting
Norton Children's Hospital	Louisville	Kentucky	40202	Recruiting
Novak Center for Children's Health	Louisville	Kentucky	40202	Recruiting
University of Louisville, Norton Children's Research Institute	Louisville	Kentucky	40202	Recruiting
Tufts Medical Center	Boston	Massachusetts	02111	Recruiting
Bristol Myers Squibb Children's Hospital at Robert Wood Johnson University Hospital	New Brunswick	New Jersey	08901	Recruiting
Rutgers University	New Brunswick	New Jersey	08901	Recruiting
Duke University - Main Hospital and Clinics	Durham	North Carolina	27710	Recruiting
Memorial Hermann Hospital - Texas Medical Center	Houston	Texas	77030	Recruiting
The University of Texas Health Science Center at Houston	Houston	Texas	77030	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 16 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06462235, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 4, 2026 · Synced May 6, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06462235 live on ClinicalTrials.gov.

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