Efficacy & Safety of Olvimulogene Nanivacirepvec & Platinum-doublet + Physician's Choice of Immune Checkpoint Inhibitor Compared to Docetaxel in NSCL Cancer
Public ClinicalTrials.gov record NCT06463665. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Phase 2 Study Assessing the Efficacy and Safety of Olvimulogene Nanivacirepvec Followed by Platinum-doublet Chemotherapy + Physician's Choice of Immune Checkpoint Inhibitor Compared With Docetaxel in Patients With NSCL Cancer After First Progression While on Front-line Immune Checkpoint Inhibitor-based Maintenance
Study identification
- NCT ID
- NCT06463665
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Genelux Corporation
- Industry
- Enrollment
- 142 participants
Conditions and interventions
Conditions
- Advanced Non-squamous Non-small-cell Lung Cancer
- Advanced Squamous Non-Small Cell Lung Carcinoma
- Metastatic Non-squamous Non Small Cell Lung Cancer
- Metastatic Squamous Non-Small Cell Lung Carcinoma
- Non-small Cell Lung Cancer
- Non-small Cell Lung Cancer Recurrent
- Non-small Cell Lung Cancer Stage III
- Non-small Cell Lung Cancer Stage IV
Interventions
- Docetaxel Drug
- Non-platinum chemotherapy: paclitaxel or nab-paclitaxel for squamous cell NSCLC or pemetrexed for nonsquamous cell NSCLC Drug
- Olvimulogene nanivacirepvec Biological
- Physician's Choice of Immune Checkpoint Inhibitor: pembrolizumab, nivolumab, cemiplimab, atezolizumab, durvalumab Drug
- Platinum chemotherapy: carboplatin or cisplatin Drug
Drug · Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 25, 2024
- Primary completion
- Jan 31, 2027
- Completion
- Jun 30, 2029
- Last update posted
- Sep 25, 2025
2024 – 2029
United States locations
- U.S. sites
- 16
- U.S. states
- 7
- U.S. cities
- 15
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Pioneer Research Center, LLC | Bullhead City | Arizona | 86442 | Recruiting |
| Clermont Oncology Center | Clermont | Florida | 34711 | Recruiting |
| Oncology & Hematology Associates of West Broward | Coral Springs | Florida | 33065 | Recruiting |
| Helios Clinical Research | Fort Lauderdale | Florida | 33316 | Recruiting |
| Bioresearch Partner | Hialeah | Florida | 33013 | Recruiting |
| University of Miami - Sylvester Comprehensive Cancer Center | Miami | Florida | 33136 | Recruiting |
| Bioresearch Partner | Miami | Florida | 33155 | Recruiting |
| Mid Florida Hematology and Oncology Center | Orange City | Florida | 32763 | Recruiting |
| BRCR Medical Center, Inc. | Plantation | Florida | 33322 | Recruiting |
| University of Maryland Medical Center Greenebaum Comprehensive Cancer Center | Baltimore | Maryland | 21201 | Recruiting |
| Michigan Hematology and Oncology Consultants | Dearborn | Michigan | 48126 | Recruiting |
| Oakland Medical Group | Farmington Hills | Michigan | 48336 | Recruiting |
| Gabrail Cancer and Research Center | Canton | Ohio | 44718 | Recruiting |
| Texas Oncology - Austin Central | Austin | Texas | 78745 | Recruiting |
| World Research Link | Baytown | Texas | 77521 | Recruiting |
| Sheboygan Cancer & Blood Center | Sheboygan | Wisconsin | 53081 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06463665, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 25, 2025 · Synced May 5, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06463665 live on ClinicalTrials.gov.