Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas

ClinicalTrials.gov ID: NCT06465199

Public ClinicalTrials.gov record NCT06465199. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Apr 22, 2026, 9:05 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Dose Escalation Study Using Eflornithine (DFMO) and AMXT 1501 Followed by a Randomized Controlled Trial of DFMO With or Without AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas

Study identification

NCT ID: NCT06465199
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1, Phase 2
Lead sponsor: Milton S. Hershey Medical Center; Other
Enrollment: 289 participants

Conditions and interventions

Conditions

Interventions

AMXT 1501 Dicaprate Drug
Eflornithine (DFMO) Drug

Drug

Eligibility (public fields only)

Age range: Up to 21 Years
Sex: All
Healthy volunteers: Not listed

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Apr 27, 2026
Primary completion: Jan 31, 2033
Completion: Jan 31, 2035
Last update posted: Apr 12, 2026

2026 – 2035

United States locations

U.S. sites: 10
U.S. states: 8
U.S. cities: 10

Facility	City	State	ZIP	Site status
University of Alabama/Children's of Alabama	Birmingham	Alabama	35233	Recruiting
Arkansas Children's Hospital	Little Rock	Arkansas	72202	Recruiting
Connecticut Children's Hospital	Hartford	Connecticut	06106	Recruiting
Nicklaus Children's Hospital	Miami	Florida	33155	Recruiting
Arnold Palmer Hospital for Children	Orlando	Florida	32806	Recruiting
St. Joseph's Children's Hospital	Tampa	Florida	33614	Recruiting
Kapiolani Medical Center for Women and Children	Honolulu	Hawaii	96813	Recruiting
Penn State Milton S. Hershey Medical Center and Children's Hospital	Hershey	Pennsylvania	17033	Recruiting
Monroe Carrell Jr. Children's Hospital at Vanderbilt	Nashville	Tennessee	37232	Recruiting
Children's Medical Center	Dallas	Texas	75235	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06465199, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 12, 2026 · Synced Apr 22, 2026

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The complete protocol, eligibility criteria, and contact information for NCT06465199 live on ClinicalTrials.gov.

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