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Recruiting Phase 3 Interventional

Phase 3 Study of T-DXd and Rilvegostomig Versus SoC in Advanced HER2-expressing Biliary Tract Cancer

ClinicalTrials.gov ID: NCT06467357

Public ClinicalTrials.gov record NCT06467357. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 5, 2026, 4:33 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

DESTINY-Biliary Tract Cancer-01: A Phase 3 Study of Trastuzumab Deruxtecan (T-DXd) and Rilvegostomig Versus Standard-of-Care Gemcitabine, Cisplatin, and Durvalumab for First Line Locally Advanced or Metastatic HER2-expressing Biliary Tract Cancer

Study identification

NCT ID
NCT06467357
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
AstraZeneca
Industry
Enrollment
620 participants

Conditions and interventions

Interventions

  • Cisplatin Drug
  • Durvalumab Drug
  • Gemcitabine Drug
  • Rilvegostomig Drug
  • Trastuzumab deruxtecan Drug

Drug

Eligibility (public fields only)

Age range
18 Years to 99 Years
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Aug 11, 2024
Primary completion
Jun 11, 2028
Completion
May 15, 2029
Last update posted
Apr 15, 2026

2024 – 2029

United States locations

U.S. sites
45
U.S. states
20
U.S. cities
40
Facility City State ZIP Site status
Research Site Scottsdale Arizona 85259 Recruiting
Research Site Tucson Arizona 85704 Withdrawn
Research Site Tucson Arizona 85719 Not yet recruiting
Research Site Fullerton California 92835 Recruiting
Research Site La Jolla California 92093 Recruiting
Research Site Los Alamitos California 90720 Suspended
Research Site Los Angeles California 90017 Recruiting
Research Site Los Angeles California 90089 Recruiting
Research Site San Francisco California 94143 Recruiting
Research Site Walnut Creek California 94598 Not yet recruiting
Research Site Washington D.C. District of Columbia 20007 Not yet recruiting
Research Site Fort Myers Florida 33901 Recruiting
Research Site Jacksonville Florida 32224 Recruiting
Research Site St. Petersburg Florida 33705 Recruiting
Research Site Tampa Florida 33606 Not yet recruiting
Research Site West Palm Beach Florida 33401 Recruiting
Research Site Atlanta Georgia 30309 Recruiting
Research Site Coeur d'Alene Idaho 83814 Withdrawn
Research Site Chicago Illinois 60612 Recruiting
Research Site Niles Illinois 60714 Recruiting
Research Site Towson Maryland 21204 Recruiting
Research Site Worcester Massachusetts 01655 Withdrawn
Research Site Detroit Michigan 48202 Withdrawn
Research Site Grand Rapids Michigan 49503 Recruiting
Research Site Rochester Minnesota 55905 Recruiting
Research Site Kansas City Missouri 64132 Recruiting
Research Site St Louis Missouri 63110 Recruiting
Research Site Albuquerque New Mexico 87102 Withdrawn
Research Site New York New York 10032 Withdrawn
Research Site White Plains New York 10601 Recruiting
Research Site Cleveland Ohio 44111 Suspended
Research Site Cleveland Ohio 44124 Suspended
Research Site Cleveland Ohio 44195 Recruiting
Research Site Columbus Ohio 43210 Recruiting
Research Site Pittsburgh Pennsylvania 15232 Not yet recruiting
Research Site Greenville South Carolina 29605 Recruiting
Research Site Nashville Tennessee 37203 Withdrawn
Research Site Austin Texas 78705 Withdrawn
Research Site Dallas Texas 75246 Recruiting
Research Site Fort Worth Texas 76104 Recruiting
Research Site Houston Texas 77030 Recruiting
Research Site Pearland Texas 77584 Withdrawn
Research Site San Antonio Texas 78217 Withdrawn
Research Site San Antonio Texas 78258 Withdrawn
Research Site Fairfax Virginia 22031 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 218 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT06467357, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Apr 15, 2026 · Synced May 5, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06467357 live on ClinicalTrials.gov.

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