Study of Navtemadlin add-on to Ruxolitinib in JAK Inhibitor-Naïve Patients With Myelofibrosis Who Have a Suboptimal Response to Ruxolitinib

ClinicalTrials.gov ID: NCT06479135

Public ClinicalTrials.gov record NCT06479135. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 6, 2026, 8:52 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3, Randomized, Double-blind, Add-on Study Evaluating the Safety and Efficacy of Navtemadlin Plus Ruxolitinib vs Placebo Plus Ruxolitinib in JAK Inhibitor-Naïve Patients With Myelofibrosis Who Have a Suboptimal Response to Ruxolitinib

Study identification

NCT ID: NCT06479135
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Kartos Therapeutics, Inc.; Industry
Enrollment: 600 participants

Conditions and interventions

Conditions

Interventions

Navtemadlin Drug
Navtemadlin placebo Drug
Ruxolitinib Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jun 2, 2024
Primary completion: Dec 30, 2026
Completion: Dec 30, 2028
Last update posted: Sep 24, 2025

2024 – 2028

United States locations

U.S. sites: 58
U.S. states: 28
U.S. cities: 55

Facility	City	State	ZIP	Site status
UAB Hospital	Birmingham	Alabama	35233	Recruiting
Banner MD Anderson Cancer Center	Gilbert	Arizona	85234	Recruiting
Mayo Clinic - Phoenix	Phoenix	Arizona	85054	Recruiting
UC San Diego Moores Cancer Center	La Jolla	California	92037	Recruiting
UCLA Hematology/Oncology Clinic - Los Angeles	Los Angeles	California	90095	Recruiting
Scripps Health, Prebys Cancer Center	San Diego	California	92103	Recruiting
The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center	Torrance	California	90502	Recruiting
Rocky Mountain Cancer Centers - Aurora	Aurora	Colorado	80012	Recruiting
Medical Oncology Hematology Consultants, PA	Newark	Delaware	19713	Recruiting
MedStar Georgetown University Hospital, Lombardi Comprehensive Cancer Center	Washington D.C.	District of Columbia	20007	Recruiting
Mayo Clinic - Jacksonville	Jacksonville	Florida	32224	Recruiting
University of Miami	Miami	Florida	33136	Recruiting
AdventHealth Cancer Institute	Orlando	Florida	32803	Recruiting
Moffitt Cancer Center	Tampa	Florida	33612	Recruiting
Mission Cancer + Blood	Des Moines	Iowa	50314	Recruiting
University of Kansas Cancer Center - Westwood	Westwood	Kansas	66205	Recruiting
Norton Cancer Institute	Louisville	Kentucky	40207	Recruiting
Mary Bird Perkins Cancer Center	Baton Rouge	Louisiana	70809	Recruiting
Johns Hopkins Sidney Kimmel Comprehensive Cancer Center	Baltimore	Maryland	21231	Recruiting
The Center for Cancer and Blood Disorders	Bethesda	Maryland	20817	Recruiting
Dana Farber Cancer Institute	Boston	Massachusetts	02215	Recruiting
University of Michigan Hospital	Ann Arbor	Michigan	48109	Recruiting
Henry Ford Cancer Institute - Brigitte Harris Cancer Pavilion	Detroit	Michigan	48202	Recruiting
Nebraska Hematology - Oncology, P.C.	Lincoln	Nebraska	68506	Recruiting
Mohtaseb Cancer Center and Blood Disorders	Henderson	Nevada	86442	Recruiting
Hackensack University Medical Center	Hackensack	New Jersey	07601	Recruiting
Brookdale University Hospital and Medical Center	Brooklyn	New York	11212	Recruiting
Cayuga Cancer Center	Ithaca	New York	14850	Recruiting
Northwell Health, R.J. Zuckerberg Cancer Center	Lake Success	New York	11042	Recruiting
ICAHN School of Medicine at Mount Sinai	New York	New York	10029-6574	Recruiting
Montefiore Einstein Comprehensive Cancer Center	The Bronx	New York	10467	Recruiting
Medical University of South Carolina (MUSC)	Charleston	North Carolina	29425-8900	Recruiting
Atrium Health Levine Cancer Institute	Charlotte	North Carolina	28204	Recruiting
Duke University Medical Center	Durham	North Carolina	27710	Recruiting
Regional Medical Oncology Center	Wilson	North Carolina	27893	Recruiting
Atrium Health Wake Forest Baptist	Winston-Salem	North Carolina	27157	Recruiting
Gabrail Cancer Center	Canton	Ohio	44718	Recruiting
University of Cincinnati Medical Center	Cincinnati	Ohio	45219	Recruiting
Cleveland Clinic Cancer Center at Fairview Hospital	Cleveland	Ohio	44111	Recruiting
Cleveland Clinic	Cleveland	Ohio	44195	Recruiting
Independence Family Health Center - Cleveland Clinic	Independence	Ohio	44131	Recruiting
Hillcrest Hospital - Cleveland Clinic	Mayfield Heights	Ohio	44124	Recruiting
Willamette Valley Cancer Institute and Research Center	Eugene	Oregon	97401	Recruiting
Abramson Cancer Center of the University of Pennsylvania	Philadelphia	Pennsylvania	19104	Recruiting
West Penn Hospital	Pittsburgh	Pennsylvania	15224	Recruiting
Tennessee Oncology	Chattanooga	Tennessee	37404	Recruiting
Tennessee Oncology	Nashville	Tennessee	37203	Recruiting
Vanderbilt University Medical Center	Nashville	Tennessee	37232	Recruiting
UT - SouthWestern	Dallas	Texas	75390	Recruiting
U.T. MD Anderson Cancer Center	Houston	Texas	77030	Recruiting
The University of Texas Health Science Center at San Antonio	San Antonio	Texas	78229	Recruiting
University of Utah, Huntsman Cancer Institute	Salt Lake City	Utah	84112	Recruiting
Virginia Cancer Institute	Richmond	Virginia	23229	Recruiting
VCU Medical Center	Richmond	Virginia	23298	Recruiting
Virginia Oncology Associates - Virginia Beach	Virginia Beach	Virginia	23456	Recruiting
Fred Hutchinson Cancer Centre	Seattle	Washington	98109	Recruiting
Northwest Medical Specialties, PLLC - Tacoma	Tacoma	Washington	98405	Recruiting
Sheboygan Cancer & Blood Specialists	Sheboygan	Wisconsin	53081	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 157 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06479135, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Sep 24, 2025 · Synced May 6, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06479135 live on ClinicalTrials.gov.

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