Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Participants With Endometrial Cancer After Platinum-Based Chemotherapy and Immunotherapy (ASCENT-GYN-01/GOG-3104/ENGOT-en26)
Public ClinicalTrials.gov record NCT06486441. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Open-label, Phase 3 Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Participants With Endometrial Cancer Who Have Received Prior Platinum-based Chemotherapy and Anti-PD-1/PD-L1 Immunotherapy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The goal of this clinical study is to find out how the study drug, sacituzumab govitecan (SG) works in participants with endometrial cancer who have received prior treatment with platinum-based chemotherapy and immunotherapy, versus the treatment of physician's choice (TPC). The primary objectives of this study are to evaluate the effect of SG compared to TPC on progression-free survival (PFS) as assessed by blinded independent central review (BICR) and overall survival (OS).
Study identification
- NCT ID
- NCT06486441
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 640 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Female
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 28, 2024 (Actual)
- Primary completion
- Jun 2029 (Estimated)
- Completion
- Jun 2029 (Estimated)
- Last update posted
- Oct 22, 2026
2024 – 2029
United States locations
- U.S. sites
- 57
- U.S. states
- 32
- U.S. cities
- 53
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Arkansas for Medical Sciences | Little Rock | Arkansas | 72205 | — |
| City of Hope | Duarte | California | 91010 | — |
| UC San Diego Medical Center | La Jolla | California | 92093 | — |
| Cedars-Sinai Cancer at Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| Stanford Women's Cancer Center | Palo Alto | California | 94304 | — |
| Kaiser Permanente Medical Center | Vallejo | California | 94589 | — |
| University of Colorado Hospital - Anschutz Cancer Pavilion (ACP) | Aurora | Colorado | 80045 | — |
| Hartford HealthCare Cancer Institute at Hartford Hospital | Hartford | Connecticut | 06102 | — |
| Yale University School of Medicine | New Haven | Connecticut | 06520 | — |
| Florida Cancer Specialists | Fort Myers | Florida | 33901 | — |
| University of Florida | Gainesville | Florida | 32610 | — |
| Baptist MD Anderson Cancer Center | Jacksonville | Florida | 32207 | — |
| Winship Cancer Institute, Emory University | Atlanta | Georgia | 30322 | — |
| Lewis Cancer & Research Pavilion at St. Joseph's/Candler Health System | Savannah | Georgia | 31405 | — |
| Northwestern Memorial Hospital | Chicago | Illinois | 60611 | — |
| University of Chicago Medical Center | Chicago | Illinois | 60637 | — |
| Indiana University Melvin and Bren Simon Comprehensive Cancer Center | Indianapolis | Indiana | 46202 | — |
| Baptist Health Lexington | Lexington | Kentucky | 40503 | — |
| Norton Cancer Institute | Louisville | Kentucky | 40207 | — |
| Ochsner Clinic Foundation | New Orleans | Louisiana | 70121 | — |
| Greater Baltimore Medical Center | Baltimore | Maryland | 21204 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Baystate Medical Center | Springfield | Massachusetts | 01199 | — |
| West Michigan Cancer Center | Kalamazoo | Michigan | 49007 | — |
| M Health Fairview University of Minnesota Medical Center - East Bank Hospital | Minneapolis | Minnesota | 55455 | — |
| Metro Minnesota Community Oncology Research Consortium (MMCORC) | Saint Louis Park | Minnesota | 55426 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216 | — |
| MidAmerica Division, Inc. c/o Research Medical Center | Kansas City | Missouri | 64132 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68105 | — |
| Dartmouth-Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | — |
| Rutgers Cancer Institute | New Brunswick | New Jersey | 08901 | — |
| University of New Mexico Comprehensive Cancer Center | Albuquerque | New Mexico | 87131 | — |
| Roswell Park Cancer Institute | Buffalo | New York | 14263 | — |
| Northwell Health Cancer Institute | Lake Success | New York | 11042 | — |
| Columbia University Medical Center, Herbert Irving Pavilion | New York | New York | 10032 | — |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | — |
| University of Rochester Medical Center | Rochester | New York | 14642 | — |
| SUNY Upstate Medical University | Syracuse | New York | 13210 | — |
| Atrium Health Wake Forest Baptist | Winston-Salem | North Carolina | 27103 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Ohio Health Research Institute | Columbus | Ohio | 43214 | — |
| Oklahoma Cancer Specialists and Research Institute - OCSRI - Tulsa | Tulsa | Oklahoma | 74146 | — |
| Providence Cancer Institute Franz Clinic | Portland | Oregon | 97213 | — |
| Alliance Cancer Specialists, PC | Horsham | Pennsylvania | 19044 | — |
| University of Pennsylvania Health System, Perelman Center for Advanced Medicine | Philadelphia | Pennsylvania | 19104 | — |
| MUSC Hollings Cancer Center | Charleston | South Carolina | 29485 | — |
| SCRI Oncology Partners | Nashville | Tennessee | 37203 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Texas Oncology | Fort Worth | Texas | 76104 | — |
| Baylor College of Medicine Medical Center | Houston | Texas | 77030 | — |
| The University of Texas MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| University of Virginia Comprehensive Cancer Center | Charlottesville | Virginia | 22908 | — |
| Virginia Oncology Associates | Norfolk | Virginia | 23502 | — |
| Fred Hutchinson Cancer Center | Seattle | Washington | 98109 | — |
| University of Wisconsin Carbone Cancer Center | Madison | Wisconsin | 53792 | — |
| Froedtert and the Medical College of Wisconsin (MCW) | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 132 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06486441, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 22, 2026 · Synced Oct 23, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06486441 live on ClinicalTrials.gov.