A Phase 3b, Single-Arm Study of Aflibercept 8 mg Dosed Every 4 Weeks in Adult Participants With Neovascular Age-Related Macular Degeneration (nAMD) or Diabetic Macular Edema (DME)
Public ClinicalTrials.gov record NCT06491914. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3b Single-Arm Study of Aflibercept 8 mg in Participants With Neovascular Age-Related Macular Degeneration (nAMD) or Diabetic Macular Edema (DME)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study is researching aflibercept high dose (HD), referred to as "study drug", with an experimental dosing regimen. The study is focused on participants with nAMD and DME that have been previously treated with anti-vascular endothelial growth factor (anti-VEGF) medications. The aim of the study is to see how safe and effective aflibercept HD injections are when given as frequently as every 4 weeks. The study is also looking at what side effects may happen from taking the study drug.
Study identification
- NCT ID
- NCT06491914
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,126 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 24, 2024 (Actual)
- Primary completion
- Aug 26, 2025 (Actual)
- Completion
- Jan 7, 2027 (Estimated)
- Last update posted
- Sep 18, 2026
2024 – 2027
United States locations
- U.S. sites
- 53
- U.S. states
- 22
- U.S. cities
- 51
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Win Retina - Arcadia | Arcadia | California | 91006 | — |
| California Retina Consultants | Bakersfield | California | 93309 | — |
| Retina Specialists of Beverly Hills | Beverly Hills | California | 90212 | — |
| Salehi Retina Institute dba Retina Associates of Southern California | Huntington Beach | California | 92647 | — |
| South Coast Retina Center | Long Beach | California | 90807 | — |
| California Eye Specialists Medical Group, Inc. | Pasadena | California | 91107 | — |
| Retina Consultants of Southern California | Redlands | California | 92374 | — |
| Vrmg Inc | Sacramento | California | 95825 | — |
| Retina Consultants of Southern Colorado | Colorado Springs | Colorado | 80909 | — |
| Eye care Center of Northern Colorado doing business as Advanced Vision Research Institute | Longmont | Colorado | 80503 | — |
| Retina Group of New England | Waterford | Connecticut | 06385 | — |
| Advanced Research, LLC | Deerfield Beach | Florida | 33064 | — |
| Florida Retina Institute - Jacksonville | Jacksonville | Florida | 32216 | — |
| Florida Retina Consultants | Lakeland | Florida | 33805 | — |
| Florida Retina Institute - Orlando | Orlando | Florida | 32806 | — |
| Retina Speciality Institute - Pensacola, Florida | Pensacola | Florida | 32503 | — |
| Eye Associates of Pinellas | Pinellas Park | Florida | 33782 | — |
| Retina Vitreous Associates of Florida Saint Petersburg | St. Petersburg | Florida | 33711 | — |
| Retina Vitreous Associates of Florida | Tampa | Florida | 33617 | — |
| Center for Retina and Macular Disease | Winter Haven | Florida | 33880 | — |
| Georgia Retina | Marietta | Georgia | 30060 | — |
| Retina Consultants of Hawaii, Inc. | ‘Aiea | Hawaii | 96701 | — |
| University Retina and Macula Associates PC - Lemont | Lemont | Illinois | 60439 | — |
| Illinois Retina Associates | Oak Park | Illinois | 60304 | — |
| Cumberland Valley Retina Consultants-Ophthalmology | Hagerstown | Maryland | 21740 | — |
| Mid Atlantic Retina Specialists Hagerstown | Hagerstown | Maryland | 21740 | — |
| Opthalmic Consultants of Boston | Boston | Massachusetts | 02114 | — |
| Retina Consultants of Minnesota | Edina | Minnesota | 55435 | — |
| Deep Blue Retina Clinical Research PLLC | Southaven | Mississippi | 38671 | — |
| Vision Research Center Eye Associates of New Mexico | Albuquerque | New Mexico | 87109 | — |
| Vitreoretinal Consultants of NY - Westbury | Westbury | New York | 11590 | — |
| North Carolina Retina Associates | Wake Forest | North Carolina | 27587 | — |
| Retina Associates of Cleveland - Beachwood | Beachwood | Ohio | 44122 | — |
| Cincinnati Eye Institute | Cincinnati | Ohio | 45242 | — |
| Tulsa Retina Consultants | Tulsa | Oklahoma | 74114 | — |
| EyeHealth Northwest | Portland | Oregon | 97225 | — |
| Mid Atlantic Retina | Bethlehem | Pennsylvania | 18017 | — |
| Sewickley Eye Group | Sewickley | Pennsylvania | 15143 | — |
| Charleston Neuroscience Institute LLC | Ladson | South Carolina | 29456 | — |
| Palmetto Retina Center | West Columbia | South Carolina | 29169 | — |
| Tennessee Retina, PC | Nashville | Tennessee | 37203 | — |
| Retina Research Institute of Texas | Abilene | Texas | 79606 | — |
| Austin Retina Associates | Austin | Texas | 78705 | — |
| Retina Consultants of Texas | Beaumont | Texas | 77707 | — |
| Retina Consultants of Texas - Houston | Bellaire | Texas | 77401 | — |
| Texas Retina Associates - Dallas | Dallas | Texas | 75231 | — |
| Southwest Retina Consultants | El Paso | Texas | 79902 | — |
| Retina Consultants of Texas | Katy | Texas | 77494 | — |
| Austin Retina Associates | Round Rock | Texas | 78681 | — |
| Retina Consultants of Texas | San Antonio | Texas | 78240 | — |
| Retina Consultants of Texas Brown Retina Institute | San Antonio | Texas | 78251 | — |
| Retina Consultants Texas | The Woodlands | Texas | 77384 | — |
| Pacific Northwest Retina | Bellevue | Washington | 98004 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06491914, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 18, 2026 · Synced Oct 18, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06491914 live on ClinicalTrials.gov.