A Study Evaluating the Efficacy and Safety of Divarasib Versus Sotorasib or Adagrasib in Participants With Previously Treated KRAS G12C-positive Advanced or Metastatic Non-Small Cell Lung Cancer
Public ClinicalTrials.gov record NCT06497556. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III, Randomized, Open-Label, Multicenter Study Evaluating the Efficacy and Safety of Divarasib Versus Sotorasib or Adagrasib in Patients With Previously Treated KRAS G12C-Positive Advanced or Metastatic Non-Small Cell Lung Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to assess the safety and efficacy of divarasib compared to locally approved KRAS G12C inhibitors (sotorasib or adagrasib) in participants with KRAS G12C-positive (KRAS G12C +) advanced or metastatic non-small cell lung cancer (NSCLC).
Study identification
- NCT ID
- NCT06497556
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 338 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 23, 2024 (Actual)
- Primary completion
- May 19, 2026 (Actual)
- Completion
- Nov 30, 2029 (Estimated)
- Last update posted
- Sep 16, 2026
2024 – 2029
United States locations
- U.S. sites
- 25
- U.S. states
- 15
- U.S. cities
- 24
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Banner Health MD Anderson AZ | Gilbert | Arizona | 85234 | — |
| Los Angeles Cancer Network | Los Angeles | California | 90017-4803 | — |
| UCLA Hematology / Oncology Clinic | Los Angeles | California | 90095 | — |
| University of California, San Francisco | San Francisco | California | 94158 | — |
| Yale Cancer Center | New Haven | Connecticut | 06519 | — |
| University of Miami | Miami | Florida | 33136 | — |
| Florida Cancer Specialists - North;725 6th Ave South (St. Petersburg) | St. Petersburg | Florida | 33701-4553 | — |
| University of Chicago Medical Center | Chicago | Illinois | 60637 | — |
| New England Cancer Specialists | Westbrook | Maine | 04092 | — |
| Dana Farber Cancer Institute | Boston | Massachusetts | 02215 | — |
| University of Michigan | Ann Arbor | Michigan | 48109-0934 | — |
| Cancer and Hematology Centers of Western Michigan | Grand Rapids | Michigan | 49503 | — |
| Minnesota Oncology Edina | Edina | Minnesota | 55435 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| Taylor Cancer Research Center | Maumee | Ohio | 43537 | — |
| Oncology Associates of Oregon, P.C | Eugene | Oregon | 97401 | — |
| Oregon Health & Science University | Portland | Oregon | 97239 | — |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111 | — |
| Allegheny Cancer Center | Pittsburgh | Pennsylvania | 15212 | — |
| Tennessee Oncology, PLLC - Chattanooga | Chattanooga | Tennessee | 37404 | — |
| Baptist Clinical Research Institute | Memphis | Tennessee | 38120 | — |
| Tennessee Oncology | Nashville | Tennessee | 37203 | — |
| JPS Health Network | Fort Worth | Texas | 76104 | — |
| MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| Texas Oncology - Northeast Texas | Longview | Texas | 75601 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 126 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06497556, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 16, 2026 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06497556 live on ClinicalTrials.gov.