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Recruiting Phase 2 Interventional

Consolidation of First-Line MRD+ Remission With Cema-cel in Patients With LBCL

ClinicalTrials.gov ID: NCT06500273

Public ClinicalTrials.gov record NCT06500273. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 2, 2026, 4:39 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized, Open-label Study Evaluating the Efficacy and Safety of Cemacabtagene Ansegedleucel in Participants With Minimal Residual Disease After Response to First Line Therapy for Large B-cell Lymphoma

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This is a randomized, open-label study in adult patients who have completed standard first line therapy for large B-cell lymphoma (LBCL) and achieved a complete response or partial response suitable for observation, but who have minimal residual disease (MRD) as detected by the Foresight CLARITY™ Investigational Use Only (IUO) MRD test, powered by PhasED-Seq™. The purpose of the trial is to assess the efficacy and safety of consolidation with cemacabtagene ansegedleucel (cema-cel), an allogeneic CD19 CAR T product, as compared to standard of care observation. In this study, participants with MRD are randomized 1:1 to treatment with cema-cel or an observation arm. Treatment includes cema-cel following a lymphodepletion regimen of fludarabine and cyclophosphamide. Prior to August 2025, participants may also have received an anti-CD52 monoclonal antibody, ALLO-647, as part of their lymphodepletion regimen.

Study identification

NCT ID
NCT06500273
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 2
Lead sponsor
Allogene Therapeutics
Industry
Enrollment
250 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jun 17, 2024
Primary completion
Nov 30, 2027
Completion
Nov 30, 2032
Last update posted
Aug 30, 2026

2024 – 2032

United States locations

U.S. sites
62
U.S. states
28
U.S. cities
53
Facility City State ZIP Site status
Banner MD Anderson Cancer Center Gilbert Arizona 85234 Recruiting
Genesis Cancer and Blood Institute Hot Springs Arkansas 71913 Recruiting
Alta Bates Summit Medical Center Berkeley California 94704 Recruiting
City of Hope Duarte California 91010 Recruiting
Cedars-Sinai Medical Center Los Angeles California 90048 Recruiting
University of California, Los Angeles Los Angeles California 90095 Recruiting
University of California, Davis Comprehensive Cancer Center Sacramento California 95817 Recruiting
University of California, San Diego San Diego California 92037 Recruiting
University of California, San Francisco San Francisco California 94143 Recruiting
Rocky Mountain Cancer Centers Lone Tree Colorado 80124 Recruiting
Medical Oncology Hematology Consultants Newark Delaware 19713 Recruiting
MedStar Georgetown University Hospital Washington D.C. District of Columbia 20007 Recruiting
Miami Cancer Institute at Baptist Health, Inc. Miami Florida 33176 Recruiting
Advent Health Cancer Institute Orlando Florida 32804 Recruiting
Orlando Health Cancer Institute Orlando Florida 32806 Recruiting
Moffitt Cancer Center Tampa Florida 33612 Recruiting
Augusta University Georgia Cancer Center Augusta Georgia 30912 Recruiting
Northwestern University - Feinberg School of Medicine Chicago Illinois 60611 Recruiting
Rush University Medical Center Chicago Illinois 60612 Recruiting
Fort Wayne Medical Oncology and Hematology Fort Wayne Indiana 46804 Recruiting
IU Simon Comprehensive Cancer Center Indianapolis Indiana 46202 Recruiting
Indiana Blood and Marrow Transplantation Indianapolis Indiana 46237 Recruiting
The University of Kansas Hospital Kansas City Kansas 66205 Active, not recruiting
University of Kentucky Medical Center Lexington Kentucky 40536 Recruiting
University of Louisville Health Brown Cancer Center Louisville Kentucky 40202 Recruiting
Norton Cancer Institute Louisville Kentucky 40207 Recruiting
University of Maryland Greenebaum Comprehensive Cancer Center Baltimore Maryland 21201 Recruiting
The Center for Cancer and Blood Disorders Bethesda Maryland 20817 Recruiting
Massachusetts General Hospital Boston Massachusetts 02114 Recruiting
Beth Israel Deaconess Medical Center Boston Massachusetts 02215 Recruiting
University of Minnesota Medical Center Minneapolis Minnesota 55455 Recruiting
University of Missouri - Ellis Fischel Cancer Center Columbia Missouri 65212 Recruiting
MidAmerica Cancer Care Kansas City Missouri 64132 Recruiting
Washington University School of Medicine - Siteman Cancer Center St Louis Missouri 63110 Recruiting
Astera Cancer Care East Brunswick New Jersey 08816 Recruiting
John Theurer Cancer Center Hackensack New Jersey 07601 Recruiting
Rutgers Cancer Institute of New Jersey New Brunswick New Jersey 08901 Recruiting
Columbia University Irving Medical Center and New York-Presbyterian Hospital New York New York 10032 Recruiting
University of Rochester Medical Center Rochester New York 14642 Recruiting
Novant Health Cancer Institute- Hematology Charlotte North Carolina 28204 Recruiting
Duke Blood Cancer Center Durham North Carolina 27705 Recruiting
Oncology Hematology Care - Kenwood Cincinnati Ohio 45236 Recruiting
University of Cincinnati Medical Center Cincinnati Ohio 45267 Recruiting
Cleveland Clinic Cleveland Ohio 44195 Recruiting
Oncology Associates of Oregon Eugene Oregon 97401 Recruiting
Oregon Health and Science University Portland Oregon 97239 Recruiting
Fox Chase Cancer Center Philadelphia Pennsylvania 19111 Recruiting
West Penn Hospital Pittsburgh Pennsylvania 15224 Recruiting
Avera Cancer Institute Sioux Falls South Dakota 57105 Recruiting
Vanderbilt University Medical Center Nashville Tennessee 37232 Recruiting
Texas Oncology - Central South Austin Texas 78705 Recruiting
Texas Oncology - Dallas Fort Worth Dallas Texas 75203 Recruiting
MD Anderson Cancer Center Houston Texas 77030 Recruiting
Texas Transplant Institute San Antonio Texas 78229 Recruiting
Texas Oncology - Tyler Tyler Texas 75702 Recruiting
Huntsman Cancer Institute, University of Utah Salt Lake City Utah 84112 Recruiting
Intermountain Health LDS Hospital Salt Lake City Utah 84142 Recruiting
University of Virginia Charlottesville Virginia 22903 Recruiting
Virginia Cancer Specialists Fairfax Virginia 22031 Recruiting
Virginia Oncology Associates - Norfolk Norfolk Virginia 23502 Recruiting
Swedish Cancer Institute Seattle Washington 98104 Recruiting
Fred Hutchinson Cancer Center Seattle Washington 98109 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 21 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT06500273, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Aug 30, 2026 · Synced Sep 2, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06500273 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →