A Study to Evaluate the Efficacy and Safety of Frexalimab, Brivekimig, or Rilzabrutinib in Participants Aged 16 to 75 Years With Primary Focal Segmental Glomerulosclerosis or Minimal Change Disease

ClinicalTrials.gov ID: NCT06500702

Public ClinicalTrials.gov record NCT06500702. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Oct 26, 2026, 8:11 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Parallel-group Treatment, Phase 2a, Multicenter, Randomized, Double-blind, Placebo-controlled Umbrella Study to Evaluate the Efficacy and Safety of Frexalimab, Brivekimig, and Rilzabrutinib in Participants Aged 16 to 75 Years With Primary Focal Segmental Glomerulosclerosis (FSGS) or Minimal Change Disease (MCD)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This is a parallel, Phase 2a, double-blind, 6-arm study for the treatment of primary focal segmental glomerulosclerosis (FSGS) or minimal change disease (MCD). The purpose of this study is to measure the change in proteinuria and its impact on the rates of remission of nephrotic syndrome with frexalimab, brivekimig or rilzabrutinib compared with placebo in participants with primary FSGS or MCD aged 16 to 75 years. Study details for each participant include: The study duration will be up to 52 weeks. The treatment duration will be 24 weeks. There will be up to 16 visits.

Study identification

NCT ID: NCT06500702
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: Sanofi; Industry
Enrollment: 84 participants

Conditions and interventions

Conditions

Interventions

Drug

Eligibility (public fields only)

Age range: 16 Years to 75 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Dec 19, 2024 (Actual)
Primary completion: Dec 23, 2026 (Estimated)
Completion: Feb 16, 2028 (Estimated)
Last update posted: Oct 19, 2026

2024 – 2028

United States locations

U.S. sites: 18
U.S. states: 13
U.S. cities: 18

Facility	City	State	ZIP	Site status
University of Alabama -The Kirklin Clinic- Site Number : 8400007	Birmingham	Alabama	35233	Recruiting
University of California Irvine Medical Center- Site Number : 8400015	Orange	California	92868	Recruiting
University of California San Francisco - Parnassus Heights- Site Number : 8400012	San Francisco	California	94143	Recruiting
University Of South Florida - Parent- Site Number : 8400025	Tampa	Florida	33612	Recruiting
Emory Children's Center- Site Number : 8400020	Atlanta	Georgia	30322	Recruiting
Northwestern Memorial Hospital- Site Number : 8400014	Chicago	Illinois	60611	Recruiting
Nephrology Associates of Northern Illinois and Indiana (NANI) - Hinsdale- Site Number : 8400017	Hinsdale	Illinois	60521	Recruiting
University of Michigan Health System - Ann Arbor- Site Number : 8400010	Ann Arbor	Michigan	48109	Recruiting
InterMed Consultants - Edina Clinic- Site Number : 8400019	Edina	Minnesota	55435	Recruiting
DaVita Clinical Research - Las Vegas - North Rainbow Boulevard- Site Number : 8400018	Las Vegas	Nevada	89107	Active, not recruiting
Renal Medicine Associates- Site Number : 8400028	Albuquerque	New Mexico	87109	Recruiting
Columbia University Irving Medical Center- Site Number : 8400001	New York	New York	10032	Recruiting
The Children's Hospital at Montefiore- Site Number : 8400027	The Bronx	New York	10467	Recruiting
UNC Kidney Center- Site Number : 8400021	Chapel Hill	North Carolina	27599	Recruiting
Cleveland Clinic - Cleveland- Site Number : 8400029	Cleveland	Ohio	44195	Recruiting
Renal Disease Research Institute - Dallas - Live Oak Street- Site Number : 8400024	Dallas	Texas	75204	Recruiting
El Paso Kidney Specialists- Site Number : 8400005	El Paso	Texas	79902	Recruiting
Prolato Clinical Research Center- Site Number : 8400016	Houston	Texas	77054	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 61 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06500702, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Oct 19, 2026 · Synced Oct 26, 2026

Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT06500702 live on ClinicalTrials.gov.

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