A Phase Ⅲ Clinical Study of HLX22 in Combination With Trastuzumab and Chemotherapy for the Treatment of Gastroesophageal Junction and Gastric Cancer
Public ClinicalTrials.gov record NCT06532006. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-blinded, Multicenter, Phase Ⅲ Clinical Study of HLX22 (Recombinant Humanized Anti-HER2 Monoclonal Antibody Injection) in Combination With Trastuzumab and Chemotherapy (XELOX) Versus Trastuzumab and Chemotherapy (XELOX) With or Without Pembrolizumab for the First Line Treatment of Locally Advanced or Metastatic Gastroesophageal Junction and Gastric Cancer
Study identification
- NCT ID
- NCT06532006
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Shanghai Henlius Biotech
- Industry
- Enrollment
- 550 participants
Conditions and interventions
Conditions
Interventions
- Capecitabine Drug
- HLX22 Drug
- Oxaliplatin Drug
- Pembrolizumab Drug
- Trastuzumab Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Not listed
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 21, 2024
- Primary completion
- May 31, 2027
- Completion
- Aug 31, 2028
- Last update posted
- Feb 26, 2026
2024 – 2028
United States locations
- U.S. sites
- 29
- U.S. states
- 14
- U.S. cities
- 27
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Los Angeles Cancer Network | Anaheim | California | 92801 | Recruiting |
| OPN - Oncology Physician Network (Los Alamitos) | Los Alamitos | California | 90720 | Recruiting |
| Banner MD Anderson Cancer Center | Greeley | Colorado | 80631 | Recruiting |
| Advanced Research LLC | Deerfield Beach | Florida | 33064 | Recruiting |
| Florida Cancer Specialist - South | Fort Myers | Florida | 33901 | Recruiting |
| BRCR Medical Center | Plantation | Florida | 33322 | Recruiting |
| Napa Research | Pompano Beach | Florida | 33064 | Recruiting |
| Florida Cancer Specialist - North | St. Petersburg | Florida | 33705 | Recruiting |
| Florida Cancer Specialist - East | West Palm Beach | Florida | 33401 | Recruiting |
| Northwestern University | Chicago | Illinois | 60611 | Recruiting |
| University of Chicago | Chicago | Illinois | 60637 | Recruiting |
| Mission Cancer + Blood (Exigent Network) | Des Moines | Iowa | 50309 | Recruiting |
| Holden Comprehensive Cancer Center - University of Iowa | Iowa City | Iowa | 52242 | Recruiting |
| Washington University School of Medicine St. Louis | St Louis | Missouri | 63110 | Recruiting |
| Nebraska Cancer Specialists | Omaha | Nebraska | 68130 | Recruiting |
| Comprehensive Cancer Centers Nevada | Las Vegas | Nevada | 89169 | Recruiting |
| Cleveland Clinic | Cleveland | Ohio | 44195 | Recruiting |
| UPMC Hillman Cancer Center | Pittsburgh | Pennsylvania | 15232 | Recruiting |
| Guthrie Medical Group, PC and Robert Packer Hospital (Guthrie Cancer Center - Sayre) | Sayre | Pennsylvania | 18840 | Recruiting |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | Recruiting |
| HCA Midwest Health | Nashville | Tennessee | 60637 | Recruiting |
| Texas Oncology - West (SCRI) | Abilene | Texas | 79606 | Recruiting |
| Texas Oncology Central South (SCRI) | Austin | Texas | 78705 | Recruiting |
| Texas Oncology Northeast (SCRI) | Denton | Texas | 76201 | Recruiting |
| The University of Texas MD Anderson cancer Center | Houston | Texas | 77030 | Recruiting |
| Texas Oncology - Gulf Coast (SCRI) | Webster | Texas | 77598 | Recruiting |
| American Oncology Network Vista Oncology Division | Olympia | Washington | 98502 | Recruiting |
| Northwest Medical Specialties | Tacoma | Washington | 98405 | Recruiting |
| West Virginia University Cancer Institute | Morgantown | West Virginia | 26506 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 179 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06532006, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 26, 2026 · Synced Apr 22, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06532006 live on ClinicalTrials.gov.