A Study to Evaluate the Efficacy and Safety of Autogene Cevumeran With Nivolumab Versus Nivolumab Alone in Participants With High-risk Muscle-invasive Urothelial Carcinoma (MIUC)
Public ClinicalTrials.gov record NCT06534983. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Phase II, Double-blind, Multicenter Study Evaluating the Efficacy and Safety of Autogene Cevumeran Plus Nivolumab Versus Nivolumab as Adjuvant Therapy in Patients With High-risk Muscle-invasive Urothelial Carcinoma
Study identification
- NCT ID
- NCT06534983
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Hoffmann-La Roche
- Industry
- Enrollment
- 362 participants
Conditions and interventions
Conditions
Interventions
- Autogene Cevumeran Drug
- Nivolumab Drug
- Saline Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 8, 2024
- Primary completion
- Nov 9, 2027
- Completion
- Nov 9, 2027
- Last update posted
- Apr 8, 2026
2024 – 2027
United States locations
- U.S. sites
- 26
- U.S. states
- 15
- U.S. cities
- 24
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Highlands Oncology Group. | Springdale | Arkansas | 72762 | Recruiting |
| Kaiser Permanente - Baldwin Park | Baldwin Park | California | 91706 | Suspended |
| City of Hope Cancer Center | Duarte | California | 91010 | Suspended |
| Kaiser Permanente - Los Angeles (N. Vermont) | Los Angeles | California | 90027 | Suspended |
| Kaiser Permanente - Riverside | Riverside | California | 92505 | Suspended |
| University of California San Francisco | San Francisco | California | 94158 | Suspended |
| Yale Cancer Center | New Haven | Connecticut | 06520 | Recruiting |
| Georgetown University Medical Center Lombardi Cancer Center | Washington D.C. | District of Columbia | 20007 | Recruiting |
| Norton Cancer Institute | Louisville | Kentucky | 40207 | Recruiting |
| Henry Ford Health System | Detroit | Michigan | 48202 | Recruiting |
| Memorial Sloan Kettering Cancer Center Basking Ridge | Basking Ridge | New Jersey | 07920 | Recruiting |
| MSK Monmouth | Middletown | New Jersey | 07748 | Recruiting |
| MSK Bergen | Montvale | New Jersey | 07645 | Recruiting |
| MSK Commack | Commack | New York | 11725 | Recruiting |
| MSK Westchester | Harrison | New York | 10604 | Recruiting |
| Columbia University Irving Medical Center | New York | New York | 10032 | Suspended |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | Recruiting |
| MSK Nassau | Uniondale | New York | 11553 | Recruiting |
| Providence Portland Medical Ctr | Portland | Oregon | 97225 | Suspended |
| AHN Cancer Institute ? Allegheny General Hospital | Pittsburgh | Pennsylvania | 15212 | Recruiting |
| Rhode Island Hospital | Providence | Rhode Island | 02903 | Suspended |
| Bon Secours - St. Francis Hospital | Greenville | South Carolina | 29607 | Recruiting |
| MD Anderson Cancer Center | Houston | Texas | 77030 | Recruiting |
| Inova Schar Cancer Institute | Fairfax | Virginia | 22031 | Recruiting |
| Fred Hutchinson Cancer Research Center | Seattle | Washington | 98109 | Recruiting |
| University of Washington Medical Center | Seattle | Washington | 98195 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 81 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06534983, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 8, 2026 · Synced May 9, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06534983 live on ClinicalTrials.gov.