A Study to Learn About the Investigational Medicine Called PF-06821497 (Mevrometostat) in Men With mCRPC Who Were Previously Treated With Abiraterone Acetate for Prostate Cancer (MEVPRO-1).
Public ClinicalTrials.gov record NCT06551324. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A PHASE 3, RANDOMIZED, OPEN-LABEL STUDY OF PF-06821497 (MEVROMETOSTAT) IN COMBINATION WITH ENZALUTAMIDE COMPARED WITH ENZALUTAMIDE OR DOCETAXEL IN PARTICIPANTS WITH METASTATIC CASTRATION RESISTANT PROSTATE CANCER PREVIOUSLY TREATED WITH ABIRATERONE ACETATE (MEVPRO-1)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Pfizer MEVPRO-1 (C2321014) is a randomized, open-label, multi-center clinical trial evaluating whether combining the study medicine (PF-06821497) with enzalutamide is safe and effective compared to physician's choice of either second-line androgen receptor (AR) directed therapy with enzalutamide or docetaxel (chemotherapy) for treating metastatic castration-resistant prostate cancer (mCRPC) after progression on prior abiraterone acetate treatment. The primary objective of this clinical trial is to assess the radiographic progression free survival (rPFS) of the combination of PF-06821497 plus enzalutamide versus physician's choice of enzalutamide or docetaxel.
Study identification
- NCT ID
- NCT06551324
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 600 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Male
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 21, 2024 (Actual)
- Primary completion
- Dec 28, 2026 (Estimated)
- Completion
- Oct 29, 2028 (Estimated)
- Last update posted
- Aug 11, 2026
2024 – 2028
United States locations
- U.S. sites
- 70
- U.S. states
- 18
- U.S. cities
- 52
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Urology Centers of Alabama | Homewood | Alabama | 35209 | — |
| Ironwood Cancer & Research Centers | Chandler | Arizona | 85224 | — |
| Ironwood Cancer & Research Centers | Gilbert | Arizona | 85297 | — |
| Ironwood Cancer & Research Centers | Glendale | Arizona | 85306 | — |
| Ironwood Cancer & Research Centers | Mesa | Arizona | 85202 | — |
| Ironwood Cancer & Research Centers | Mesa | Arizona | 85206 | — |
| Ironwood Cancer & Research Centers | Phoenix | Arizona | 85028 | — |
| Ironwood Cancer & Research Centers | Scottsdale | Arizona | 85260 | — |
| Los Angeles Cancer Network | Anaheim | California | 92805 | — |
| UCSF Cancer Center Berkeley | Berkeley | California | 94702 | — |
| UCSF Cancer Center Burlingame | Burlingame | California | 94010 | — |
| Los Angeles Cancer Network | Fountain Valley | California | 92708 | — |
| Los Angeles Cancer Network | Glendale | California | 91204 | — |
| Los Angeles Cancer Network | Glendale | California | 91206 | — |
| Los Angeles Cancer Network | Los Angeles | California | 90017 | — |
| Los Angeles Cancer Network | Los Angeles | California | 90067 | — |
| Stanford Cancer Center | Palo Alto | California | 94305 | — |
| UCSF Investigational Drug Pharmacy | San Francisco | California | 94158 | — |
| UCSF Medical Center at Mission Bay | San Francisco | California | 94158 | — |
| UCSF Cancer Center San Mateo | San Mateo | California | 94402 | — |
| Sutter Santa Rosa | Santa Rosa | California | 95403 | — |
| Stanford Health Care Attention: Investigational Pharmacy | Stanford | California | 94305 | — |
| Colorado Clinical Research | Lakewood | Colorado | 80228 | — |
| University of Miami Sylvester Comprehensive Cancer Center - Aventura | Aventura | Florida | 33180 | — |
| Florida Cancer Specialists | Bradenton | Florida | 34211 | — |
| Florida Cancer Specialists | Cape Coral | Florida | 33909 | — |
| University of Miami Sylvester Comprehensive Cancer Center - The Lennar Foundation Medical Center | Coral Gables | Florida | 33146 | — |
| University of Miami Sylvester Comprehensive Cancer Center - Deerfield Beach | Deerfield Beach | Florida | 33442 | — |
| University of Miami Hospital and Clinics - Doral | Doral | Florida | 33166 | — |
| Florida Cancer Specialists | Fort Myers | Florida | 33905 | — |
| Florida Cancer Specialists | Fort Myers | Florida | 33908 | — |
| University of Miami Sylvester Comprehensive Cancer Center - Kendall | Kendall | Florida | 33176 | — |
| University of Miami Hospital and Clinics, Sylvester Cancer Center | Miami | Florida | 33136 | — |
| University of Miami Hospital and Clinics, UHealth Tower | Miami | Florida | 33136 | — |
| University of Miami Sylvester Comprehensive Cancer Center - Griffin Cancer Research Building | Miami | Florida | 33136 | — |
| Florida Cancer Specialists | N. Venice | Florida | 34275 | — |
| Florida Cancer Specialists | Naples | Florida | 34102 | — |
| AdventHealth Hematology and Oncology | Orlando | Florida | 32804 | — |
| AdventHealth Orlando Infusion Center | Orlando | Florida | 32804 | — |
| University of Miami Sylvester Comprehensive Cancer Center - Plantation | Plantation | Florida | 33324 | — |
| Florida Cancer Specialists | Port Charlotte | Florida | 33980 | — |
| Florida Cancer Specialists | Sarasota | Florida | 34236 | — |
| Florida Cancer Specialists | Sarasota | Florida | 34239 | — |
| Duly Health and Care | Lisle | Illinois | 60532 | — |
| NextStage Clinical Research-Chicago-(04) | Lisle | Illinois | 60532 | — |
| Duly Health and Care | Westmont | Illinois | 60559 | — |
| The University of Louisville, James Graham Brown Cancer Center | Louisville | Kentucky | 40202 | — |
| University of Louisville Hospital | Louisville | Kentucky | 40202 | — |
| UofL Health Medical Center Northeast | Louisville | Kentucky | 40245 | — |
| New England Cancer Specialists | Topsham | Maine | 04086 | — |
| New England Cancer Specialists | Westbrook | Maine | 04092 | — |
| VA St. Louis Health Care System | St Louis | Missouri | 63106 | — |
| AtlantiCare Health Park - Cape May Court House | Cape May Court House | New Jersey | 08210 | — |
| AtlantiCare | Egg Harbor | New Jersey | 08234 | — |
| Circuit Clinical /Crystal Run Healthcare LLP | Middletown | New York | 10941 | — |
| Circuit Clinical | Middletown | New York | 10941 | — |
| Crystal Run Healthcare | Monroe | New York | 10950 | — |
| James J. Peters VA Medical Center | The Bronx | New York | 10468 | — |
| Salisbury VA Medical Center | Salisbury | North Carolina | 28144 | — |
| The Centers for Advanced Urology, LLP d/b/a Keystone Urology Specialists | Lancaster | Pennsylvania | 17604 | — |
| AUC Urologists, LLC | Myrtle Beach | South Carolina | 29572 | — |
| Carolina Urologic Research Center, LLC | Myrtle Beach | South Carolina | 29572 | — |
| Grand Strand Medical Center | Myrtle Beach | South Carolina | 29572 | — |
| Parkway Surgery Center | Myrtle Beach | South Carolina | 29572 | — |
| SCRI Oncology Partners | Nashville | Tennessee | 37203 | — |
| USA Clinical Trials | San Antonio | Texas | 78229 | — |
| Huntsman Cancer Institute | Salt Lake City | Utah | 84112 | — |
| Harborview Medical Center | Seattle | Washington | 98104 | — |
| Fred Hutchinson Cancer Center | Seattle | Washington | 98109 | — |
| University of Washington Medical Center - Montlake | Seattle | Washington | 98195 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 154 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06551324, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 11, 2026 · Synced Oct 19, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06551324 live on ClinicalTrials.gov.