A Study to Evaluate the Efficacy and Safety of Tarcocimab Tedromer and Tabirafusp Tedromer Compared to Aflibercept in Participants With Neovascular (Wet) Age-related Macular Degeneration (wAMD) - DAYBREAK
Public ClinicalTrials.gov record NCT06556368. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Prospective, Randomized, Double-masked, Active Comparator-controlled, Multi-center, Three-arm Phase 3 Study to Evaluate the Efficacy and Safety of Intravitreal Tarcocimab Tedromer and Tabirafusp Tedromer Compared With Intravitreal Aflibercept in Participants With Neovascular (Wet) Age-related Macular Degeneration (wAMD)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
A Study to Evaluate the Efficacy and Safety of Tarcocimab Tedromer and Tabirafusp Tedromer Compared to Aflibercept in Participants with Neovascular (Wet) Age-related Macular Degeneration (wAMD)
Study identification
- NCT ID
- NCT06556368
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 675 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 23, 2024 (Actual)
- Primary completion
- Aug 2026 (Estimated)
- Completion
- Aug 2027 (Estimated)
- Last update posted
- Apr 29, 2026
2024 – 2027
United States locations
- U.S. sites
- 71
- U.S. states
- 25
- U.S. cities
- 69
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Associated Retina Consultants | Gilbert | Arizona | 85297 | — |
| Associated Retina Consultants | Phoenix | Arizona | 85020 | — |
| Retina Macula Institute of Arizona | Scottsdale | Arizona | 85255 | — |
| Retina Associates SW | Tucson | Arizona | 85704 | — |
| Retina Consultants of Orange County | Fullerton | California | 92835 | — |
| Global Research Management, Inc. - Lugene Eye Institute | Glendale | California | 91204 | — |
| Retinal Consultants Medical Group, Inc. | Modesto | California | 95356 | — |
| California Eye Specialists Medical Group, Inc. | Pasadena | California | 91107 | — |
| California Eye Specialists Medical Group, Inc. | Redlands | California | 92373 | — |
| Retinal Consultants Medical Group Inc | Sacramento | California | 95825 | — |
| Retina Consultants of Southern Colorado | Colorado Springs | Colorado | 80909 | — |
| Retina Group of New England, PC | Waterford | Connecticut | 06385 | — |
| Blue Ocean Clinical Research | Clearwater | Florida | 33761 | — |
| Retina Group of Florida | Fort Lauderdale | Florida | 33308 | — |
| National Ophthalmic Research Institute | Fort Myers | Florida | 33912 | — |
| Retina Group of Florida | Sarasota | Florida | 34232 | — |
| Center for Retina and Macular Disease | Winter Haven | Florida | 33880 | — |
| Southeast Retina Center | Augusta | Georgia | 30909 | — |
| Retina Associates, Ltd | Elmhurst | Illinois | 60126 | — |
| Illinois Retina Associates | Oak Park | Illinois | 60304 | — |
| Associated Vitreoretinal and Uveitis Consultants LLC | Carmel | Indiana | 46032 | — |
| Midwest Eye Institute | Carmel | Indiana | 46290 | — |
| The Retina Care Center | Baltimore | Maryland | 21209 | — |
| Cumberland Valley Retina Consultants | Hagerstown | Maryland | 21740 | — |
| Ophthalmic Consultants of Boston | Boston | Massachusetts | 02114 | — |
| Retina Consultants of Minnesota | Edina | Minnesota | 55435 | — |
| Retina Consultants of Minnesota | Saint Louis Park | Minnesota | 55416 | — |
| Mississippi Retina Associates | Madison | Mississippi | 39110 | — |
| The Retina Institute | St Louis | Missouri | 63128 | — |
| Retina Consultants of Nevada | Henderson | Nevada | 89052 | — |
| Long Island Vitreoretinal Consultants | Hauppauge | New York | 11788 | — |
| Retina Vitreous Surgeons of CNY PC | Liverpool | New York | 13088 | — |
| Retina Associates of Western NY | Rochester | New York | 14620 | — |
| Asheville Eye Associates | Asheville | North Carolina | 28803 | — |
| North Carolina Retina Associates | Cary | North Carolina | 27511 | — |
| Piedmont Retina Specialist | Greensboro | North Carolina | 27401 | — |
| Graystone Eye | Hickory | North Carolina | 28602 | — |
| North Carolina Retina Associates | Wake Forest | North Carolina | 27587 | — |
| Western Carolina Clinical Research, LLC | Winston-Salem | North Carolina | 27103 | — |
| Retina Northwest | Portland | Oregon | 97210 | — |
| Cascade Medical Research Institute | Springfield | Oregon | 97477 | — |
| Erie Retina Research | Erie | Pennsylvania | 16507 | — |
| Vision Research Solutions PLLC | Philadelphia | Pennsylvania | 19141 | — |
| Palmetto Retina Center | Aiken | South Carolina | 29802 | — |
| Charleston Neuroscience Institute, LLC | Beaufort | South Carolina | 29902 | — |
| Charleston Neuroscience Institute, LLC | Charleston | South Carolina | 29414 | — |
| Charleston Neuroscience Institute, LLC | Ladson | South Carolina | 29456 | — |
| Charleston Neuroscience Institute | Mt. Pleasant | South Carolina | 29464 | — |
| Palmetto Retina Center | West Columbia | South Carolina | 29169 | — |
| Ophthalmology Ltd | Sioux Falls | South Dakota | 57108 | — |
| Charles Retina Institute | Germantown | Tennessee | 38138 | — |
| Retina Research Institute of Texas | Abilene | Texas | 79606 | — |
| Panhandle Eye Group, LLP. - Southwest Retina Specialists | Amarillo | Texas | 79106 | — |
| Texas Retina Associates | Arlington | Texas | 76012 | — |
| Austin Research Center for Retina | Austin | Texas | 78705 | — |
| Austin Retina Associates, PLLC | Austin | Texas | 78705 | — |
| Retina Consultants of Texas | Bellaire | Texas | 77401 | — |
| Star Vision Research | Burleson | Texas | 76028 | — |
| Texas Retina Associates | Fort Worth | Texas | 76104 | — |
| Texas Retina Center | Houston | Texas | 77030 | — |
| Retina Consultants of Texas | Katy | Texas | 77494 | — |
| Texas Retina Associates | Plano | Texas | 75075 | — |
| Austin Retina Associates, PLLC | Round Rock | Texas | 78681 | — |
| Retinal Consultants of Houston dba Retina Consultants of Texas | San Antonio | Texas | 78240 | — |
| Retina Consultants of Texas | Schertz | Texas | 78154 | — |
| Retina Consultants of Texas | The Woodlands | Texas | 77384 | — |
| Strategic Clinical Research Group, LLC | Willow Park | Texas | 76087 | — |
| Piedmont Eye Center | Lynchburg | Virginia | 24502 | — |
| Pacific Northwest Retina | Bellevue | Washington | 98004 | — |
| Spokane Eye Clinical Research | Spokane | Washington | 99204 | — |
| Eye Clinic of Wisconsin | Wausau | Wisconsin | 54403 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06556368, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 29, 2026 · Synced Oct 20, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06556368 live on ClinicalTrials.gov.