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Recruiting Phase 3 Interventional

EF-41/KEYNOTE D58: Phase 3 Study of Optune Concomitant With Temozolomide Plus Pembrolizumab in Newly Diagnosed Glioblastoma

ClinicalTrials.gov ID: NCT06556563

Public ClinicalTrials.gov record NCT06556563. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 3, 2026, 5:23 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Optune® (TTFields, 200 kHz) Concomitant With Maintenance Temozolomide and Pembrolizumab Versus Optune® Concomitant With Maintenance Temozolomide and Placebo for the Treatment of Newly Diagnosed Glioblastoma (EF-41/KEYNOTE D58).

Study identification

NCT ID
NCT06556563
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
NovoCure GmbH
Industry
Enrollment
741 participants

Conditions and interventions

Conditions

Interventions

  • Optune® device Device
  • Pembrolizumab Drug
  • Placebo Drug
  • Temozolomide Drug

Device · Drug

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Feb 2, 2025
Primary completion
Mar 31, 2029
Completion
Mar 31, 2029
Last update posted
Apr 30, 2026

2025 – 2029

United States locations

U.S. sites
32
U.S. states
20
U.S. cities
30
Facility City State ZIP Site status
Mayo Clinic Hospital Phoenix Arizona 85054 Recruiting
University of Southern California Los Angeles California 90033 Recruiting
Hoag Memorial Hospital Presbyterian Newport Beach California 92663 Recruiting
Stanford Cancer Institute Palo Alto California 94305 Recruiting
University of California San Francisco California 94143 Recruiting
UF Health Neuromedicine Gainesville Florida 32608 Recruiting
Mayo Clinic - Florida Jacksonville Florida 32224 Recruiting
Miami Cancer Institute Miami Florida 33176 Recruiting
Moffitt Cancer Center Tampa Florida 33612 Recruiting
Northwestern Memorial Hospital Chicago Illinois 60611 Recruiting
University of Kentucky Medical Center Lexington Kentucky 40536 Recruiting
University of Maryland Baltimore Maryland 21201 Recruiting
Tufts Medical Center Boston Massachusetts 02111 Recruiting
Masonic Cancer Center, University of Minnesota Minneapolis Minnesota 55455 Recruiting
Mayo Clinic - Rochester Rochester Minnesota 55905 Recruiting
Washington University St Louis Missouri 63110 Recruiting
Renown Regional Medical Center Reno Nevada 89502 Recruiting
John Theurer Cancer Center/ Hackensack Meridian Health Hackensack New Jersey 07601 Recruiting
Northwell Health Lake Success New York 11042 Recruiting
Columbia University Irving Medical Center New York New York 10032 Recruiting
Montefiore Medical Center- Montefiore Medical Park The Bronx New York 10461 Recruiting
Duke University Medical Center Durham North Carolina 27710 Recruiting
University Hospitals Cleveland Medical Center Cleveland Ohio 44106 Recruiting
The Cleveland Clinic Cleveland Ohio 44195 Recruiting
Thomas Jefferson University, Sidney Kimmel Comprehensive Cancer Center, Clinical Trials Organization Philadelphia Pennsylvania 19107 Recruiting
UPMC Hillman Cancer Center Pittsburgh Pennsylvania 15232 Recruiting
Rhode Island Hospital Providence Rhode Island 02903 Recruiting
The University of Texas Houston Texas 77030 Recruiting
University of Texas, MD Anderson Cancer Center Houston Texas 77030 Recruiting
Huntsman Cancer Institute, University of Utah Salt Lake City Utah 84112 Recruiting
Inova Schar Cancer Institute Fairfax Virginia 22031 Recruiting
Swedish Medical Center Seattle Washington 98122 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 60 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT06556563, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Apr 30, 2026 · Synced May 3, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06556563 live on ClinicalTrials.gov.

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