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Recruiting Phase 3 Interventional

Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant

ClinicalTrials.gov ID: NCT06563895

Public ClinicalTrials.gov record NCT06563895. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 19, 2026, 10:29 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3, Randomized, Multicenter, Double-Blind, Placebo-Controlled Study of Acoramidis for Transthyretin Amyloidosis Prevention in the Young (ACT-EARLY Trial)

Study identification

NCT ID
NCT06563895
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
Eidos Therapeutics, a BridgeBio company
Industry
Enrollment
587 participants

Conditions and interventions

Interventions

  • Acoramidis Drug
  • Placebo oral tablet Drug

Drug

Eligibility (public fields only)

Age range
18 Years to 75 Years
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
May 11, 2025
Primary completion
Sep 30, 2031
Completion
Nov 30, 2032
Last update posted
May 11, 2026

2025 – 2032

United States locations

U.S. sites
39
U.S. states
23
U.S. cities
33
Facility City State ZIP Site status
University of California, San Diego (UCSD) - Medical Center La Jolla California 92037 Recruiting
University of California, Los Angeles (UCLA) - David Geffen School of Medicine Los Angeles California 90095 Recruiting
University of California, San Francisco (UCSF) San Francisco California 94143 Recruiting
Stanford University Stanford California 94305 Recruiting
University of Colorado Anschutz Aurora Colorado 80045 Recruiting
Yale University School of Medicine - Section of Cardiology New Haven Connecticut 06519 Recruiting
MedStar Washington Hospital Center - MedStar Heart and Vascular Institute Washington D.C. District of Columbia 20010 Recruiting
Mayo Clinic - Jacksonville Jacksonville Florida 32224 Recruiting
Cleveland Clinic Florida Weston Florida 33331 Recruiting
Emory University School of Medicine Atlanta Georgia 30322 Recruiting
John H. Stroger, Jr. Hospital of Cook County Chicago Illinois 60612 Recruiting
University of Chicago - Medical Center Chicago Illinois 60637 Recruiting
University of Maryland Medical Center Baltimore Maryland 21201 Recruiting
Johns Hopkins University Baltimore Maryland 21287 Recruiting
Massachusetts General Hospital Boston Massachusetts 02114 Recruiting
Brigham and Women's Hospital Boston Massachusetts 02115 Recruiting
Boston University (BU) School of Medicine Boston Massachusetts 02118 Recruiting
Henry Ford Health System Detroit Michigan 48202 Recruiting
Mayo Clinic - Rochester Rochester Minnesota 55905 Recruiting
St. Luke's Hospital of Kansas City Kansas City Missouri 64111 Recruiting
Washington University in St. Louis St Louis Missouri 63110 Recruiting
Rutgers-Robert Wood Johnson Medical School New Brunswick New Jersey 08901 Recruiting
New York University (NYU) School of Medicine - Langone Medical Center New York New York 10016 Recruiting
Mount Sinai Hospital New York New York 10029 Recruiting
Columbia University Medical Center New York New York 10032 Recruiting
Laurelton Heart Specialists Rosedale New York 11422 Recruiting
Duke University Medical Center Durham North Carolina 27710 Recruiting
Cleveland Clinic Cleveland Ohio 44195 Recruiting
Oregon Health & Science University Portland Oregon 97239 Recruiting
Penn Presbyterian Medical Center Philadelphia Pennsylvania 19104 Recruiting
University of Pittsburgh Medical Center, Presbyterian Hospital Pittsburgh Pennsylvania 15213 Recruiting
Medical University of South Carolina (MUSC) Charleston South Carolina 29425 Recruiting
Prisma Health Cancer Institute Greenville South Carolina 89605 Recruiting
National Neuromuscular Research Institute Austin Texas 78759 Recruiting
University of Texas Southwestern Dallas Texas 75390 Recruiting
University of Utah Salt Lake City Utah 84132 Recruiting
INOVA Fairfax Hospital Falls Church Virginia 22042 Recruiting
Virginia Commonwealth University Richmond Virginia 23219 Recruiting
University of Washington Medical Center Seattle Washington 98195 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 62 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT06563895, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted May 11, 2026 · Synced May 19, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06563895 live on ClinicalTrials.gov.

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