"A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder"
Public ClinicalTrials.gov record NCT06564818. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III, Placebo-Controlled, Randomized, Double-Blind Trial of Oral Doses of CYB003 to Assess Combined Safety and Efficacy in Humans With Major Depressive Disorder
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to examine the efficacy, safety, and tolerability of CYB003 compared to matching placebo as adjunctive treatment in participants with MDD.
Study identification
- NCT ID
- NCT06564818
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 220 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 17, 2024 (Actual)
- Primary completion
- Sep 4, 2026 (Actual)
- Completion
- Oct 2026 (Estimated)
- Last update posted
- Sep 28, 2026
2024 – 2026
United States locations
- U.S. sites
- 45
- U.S. states
- 18
- U.S. cities
- 38
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Scottsdale Research Institute | Phoenix | Arizona | 85022 | — |
| Mountain Clinical Trials | Phoenix | Arizona | 85050 | — |
| Noble Clinical Research | Tucson | Arizona | 85704 | — |
| Del Sol Research Management | Tucson | Arizona | 85715 | — |
| CenExel CIT (Clinical Innovations, Inc) | Bellflower | California | 90706 | — |
| Kadima Neuropsychiatry Institute | La Jolla | California | 92037 | — |
| Bespoke Treatment/Lipov Medical Group | Los Angeles | California | 90025 | — |
| Catalina Research Institute | Montclair | California | 91763 | — |
| Excell Research, Inc | Oceanside | California | 92056 | — |
| Open Mind Therapeutics | San Francisco | California | 94114 | — |
| Inland Psychiatric Medical Group Inc | San Juan Capistrano | California | 92675 | — |
| Mountain View Clinical Research | Denver | Colorado | 80209 | — |
| Starlight Clinical Research | Evergreen | Colorado | 80439 | — |
| Research Centers of America | Hollywood | Florida | 33024 | — |
| K2 Medical Research-Maitland | Maitland | Florida | 32751 | — |
| Floridian Neuroscience Institute | Miami | Florida | 33135 | — |
| Segal Trials West Broward | North Miami | Florida | 33161 | — |
| Clinical Neuroscience Solutions, Inc | Orlando | Florida | 32801 | — |
| Charter Research | Orlando | Florida | 32803 | — |
| Combined Research Orlando Phase I-IV | Orlando | Florida | 32807 | — |
| K2 Medical Research - Tampa | Tampa | Florida | 33634 | — |
| Atlanta Center for Medical Research, CenExel | Atlanta | Georgia | 30331 | — |
| CenExel iResearch Atlanta | Decatur | Georgia | 30330 | — |
| CenExel iResearch Savannah | Savannah | Georgia | 31405 | — |
| Great Lakes Clinical Trials, DBA Flourish Research | Chicago | Illinois | 60640 | — |
| Uptown Research Institute | Chicago | Illinois | 60640 | — |
| Psychiatric Medicine Associates, LLC | Skokie | Illinois | 60076 | — |
| DelRicht Research | New Orleans | Louisiana | 70115 | — |
| Sunstone Medical, PC | Rockville | Maryland | 20850 | — |
| Adams Clinical Boston | Boston | Massachusetts | 02116 | — |
| Adams Clinical | Boston | Massachusetts | 02472 | — |
| Elixia Health | Springfield | Massachusetts | 01103 | — |
| Redbird Research, LLC | Las Vegas | Nevada | 89119 | — |
| Oasis Clinical Trials | Las Vegas | Nevada | 89121 | — |
| Global Medical Institutes, Princeton Medical Institute | Princeton | New Jersey | 08540 | — |
| Adams Clinical Harlem | New York | New York | 100029 | — |
| Adams Clinical Bronx | The Bronx | New York | 10461 | — |
| Monroe Biomedical Research | Monroe | North Carolina | 28112 | — |
| Neurobehavioral Clinical Research | North Canton | Ohio | 44720 | — |
| Adams Clinical Philadelphia | Philadelphia | Pennsylvania | 19104 | — |
| Clinical Neuroscience Solutions, CNS Healthcare | Memphis | Tennessee | 38119 | — |
| InSite Clinical Research, LLC | DeSoto | Texas | 75115 | — |
| Zillan Clinical Research | Houston | Texas | 77433 | — |
| Cedar Clinical Research | Murray | Utah | 84107 | — |
| Inner Space Research, LLC | Orem | Utah | 84058 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06564818, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 28, 2026 · Synced Oct 19, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06564818 live on ClinicalTrials.gov.