ClinicalTrials.gov record
Efficacy of Dupilumab Added to Medium Dose Inhaled Corticosteroid/Long-acting Beta-agonist (ICS/LABA) in Comparison to ICS Dose Escalation to High Dose ICS/LABA in Adolescent and Adult Patients With Uncontrolled Asthma
ClinicalTrials.gov ID: NCT06572228
Public ClinicalTrials.gov record NCT06572228. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced Apr 23, 2026, 7:08 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
AIM4: Next Step - Asthma Uncontrolled With ICS in Medium Dose (GINA 4): Next Step; Efficacy of Dupilumab Added to Medium Dose ICS/LABA in Comparison to ICS Dose Escalation to High Dose ICS/LABA in Patients With Uncontrolled Asthma
Study identification
- NCT ID
- NCT06572228
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 4
- Lead sponsor
- Regeneron Pharmaceuticals
- Industry
- Enrollment
- 250 participants
Conditions and interventions
Conditions
Interventions
- ICS/LABA Drug
- Matching Placebo Drug
- dupilumab Drug
Drug
Eligibility (public fields only)
- Age range
- 12 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 25, 2024
- Primary completion
- Dec 30, 2026
- Completion
- Dec 30, 2026
- Last update posted
- Apr 21, 2026
2024 – 2026
United States locations
- U.S. sites
- 55
- U.S. states
- 23
- U.S. cities
- 54
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Kern Research, Inc | Bakersfield | California | 93301 | Active, not recruiting |
| Modena Allergy & Asthma, Inc. | La Jolla | California | 92037 | Active, not recruiting |
| Antelope Valley Clinical Trials | Lancaster | California | 93534 | Active, not recruiting |
| Ark Clinical Research, LLC | Long Beach | California | 90815 | Active, not recruiting |
| Newport Native Md, Inc. | Newport Beach | California | 92663 | Active, not recruiting |
| Childrens Hospital of Orange County Main Campus | Orange | California | 92868 | Recruiting |
| Riviera Allergy Medical Center | Redondo Beach | California | 90277 | Withdrawn |
| Raffi Tachdjian MD, Inc. | Santa Monica | California | 90404 | Completed |
| Bensch Clinical Research | Stockton | California | 95207 | Active, not recruiting |
| Integrated Research of Inland, Inc. | Upland | California | 91786 | Completed |
| Allianz Research Institute | Westminster | California | 92683 | Active, not recruiting |
| National Jewish Health | Denver | Colorado | 80206 | Active, not recruiting |
| St Francis Medical Institute | Clearwater | Florida | 33765 | Active, not recruiting |
| Florida Lung, Asthma and Sleep Specialists (FLASS) - Celebration | Kissimmee | Florida | 34746 | Active, not recruiting |
| Clinical Site Partners, LLC DBA Flourish Research | Winter Park | Florida | 32789 | Active, not recruiting |
| Treasure Valley Medical Research | Boise | Idaho | 83706 | Active, not recruiting |
| Northwestern University | Chicago | Illinois | 60611 | Withdrawn |
| Sneeze Wheeze and Itch Associates | Normal | Illinois | 61761 | Active, not recruiting |
| Asthma and Allergy Center of Chicago | River Forest | Illinois | 60305 | Active, not recruiting |
| Endeavor Health, Skokie Campus | Skokie | Illinois | 60077 | Active, not recruiting |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | Active, not recruiting |
| Bluegrass Allergy Research | Lexington | Kentucky | 40509 | Active, not recruiting |
| Family Allergy and Asthma Research Institute | Louisville | Kentucky | 40217 | Recruiting |
| Allergy & Asthma Specialists, P.S.C. | Owensboro | Kentucky | 42301 | Active, not recruiting |
| Paul A. Shapero, M.D. | Bangor | Maine | 04401 | Active, not recruiting |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | Recruiting |
| Michigan Medicine | Ann Arbor | Michigan | 48109 | Active, not recruiting |
| Henry Ford Hospital | Detroit | Michigan | 48202 | Active, not recruiting |
| Allergy and Asthma Center of Minnesota | Maplewood | Minnesota | 55109 | Withdrawn |
| Clinical Research Institute, Inc. | Minneapolis | Minnesota | 55402 | Active, not recruiting |
| Washington University School of Medicine | St Louis | Missouri | 63119 | Active, not recruiting |
| Montana Medical Research | Missoula | Montana | 59808 | Active, not recruiting |
| The Asthma and Allergy Center | Bellevue | Nebraska | 68123 | Active, not recruiting |
| Henderson Clinical Trials | Henderson | Nevada | 89052 | Active, not recruiting |
| Certified Research Associates | Cortland | New York | 13045 | Active, not recruiting |
| New York Medical College | Hawthorne | New York | 10532 | Recruiting |
| Northwell Health at ENT & Allergy Associates | New York | New York | 10016 | Recruiting |
| Rochester Regional Health - Alexander Park - Allergy, Immunology & Rheumatology | Rochester | New York | 14607 | Active, not recruiting |
| Cincinnati Childrens Hospital and Medical Center | Cincinnati | Ohio | 45229 | Recruiting |
| Allergy Asthma and Clinical Research Center | Oklahoma City | Oklahoma | 73120 | Active, not recruiting |
| Clinical Research Associates of Central PA | DuBois | Pennsylvania | 15801 | Completed |
| University of Pittsburgh Asthma and Environmental Health Lung Institute | Pittsburgh | Pennsylvania | 15213 | Active, not recruiting |
| Pulmonology Associates Inc. | Wynnewood | Pennsylvania | 19096 | Recruiting |
| Dharma MD PA d/b/a Southwest Family Medicine Associates | Dallas | Texas | 75235 | Active, not recruiting |
| Premier Pulmonary Critical Care and Sleep Medicine | Denison | Texas | 75020 | Active, not recruiting |
| Western Sky Medical Research | El Paso | Texas | 79912 | Active, not recruiting |
| Baylor College of Medicine - Section of Pulmonary and Critical Care | Houston | Texas | 77030 | Active, not recruiting |
| Texas Children's Hospital | Houston | Texas | 77030 | Active, not recruiting |
| Metroplex Pulmonary and Sleep Center, PA | McKinney | Texas | 75069 | Active, not recruiting |
| Lung Sleep Research Institute | North Richland Hills | Texas | 76180 | Active, not recruiting |
| South Texas Allergy & Asthma Medical Professionals (STAAMP) Research | San Antonio | Texas | 78229 | Active, not recruiting |
| Allergy & Asthma Care of Waco | Waco | Texas | 76712 | Active, not recruiting |
| Intermountain Medical Center - Murray (Pulmonary Medicine) | Murray | Utah | 84107 | Recruiting |
| Inova Fairfax Hospital | Falls Church | Virginia | 22042 | Completed |
| Vancouver Clinic | Vancouver | Washington | 98664 | Withdrawn |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 29 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06572228, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 21, 2026 · Synced Apr 23, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06572228 live on ClinicalTrials.gov.