PREVENT ALL ALS Study
Public ClinicalTrials.gov record NCT06581861. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
PREVENT ALL ALS - Longitudinal Biomarker Study for Participants Who Are Genetically at Risk for Amyotrophic Lateral Sclerosis (ALS)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The ALL ALS Clinical Research Consortium is establishing research to collect a wide range of samples, clinical information and measurements from Amyotrophic Lateral Sclerosis (ALS) symptomatic, ALS gene carriers and control cohorts. This consortium is begin funded by the National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS) and managed by two clinical coordinating centers (CCC) at Barrow Neurological Institute and Massachusetts General Hospital. The clinical sites are distributed across the country, and led by a group of collaborative principal investigators. Once data and samples are collected and harmonized, it will be made available to research community for future research into ALS and related neurological diseases. PREVENT protocol is specific for asymptomatic participants who are genetically at risk for ALS. The participants will be followed for up to 36 months (3 years), and will include 4 in-person on-site visits once a year and 6 off-site(remote) visits once in 4 months. The study includes collection of medical history, clinical outcomes, and blood samples once in 4 months. Additionally, the participants will complete patient reported outcomes and speech recordings once in 4 months. Participants may also provide optional Cerebrospinal Fluid (CSF) samples.The participants may also opt into a sub-study if they are interested in genetic testing for ALS causative genes. The sub-study will involve a minimum of 3 visits over a course of 2-3 months. This will include a screening/pre-test genetic counseling visit, a return of genetic results and a post-test counseling visit.
Study identification
- NCT ID
- NCT06581861
- Recruitment status
- Recruiting
- Study type
- Observational
- Phase
- Not listed
- Enrollment
- 600 participants
Conditions and interventions
Conditions
Interventions
Not listed
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 25, 2024 (Actual)
- Primary completion
- Jan 31, 2029 (Estimated)
- Completion
- Jul 25, 2029 (Estimated)
- Last update posted
- Aug 24, 2026
2024 – 2029
United States locations
- U.S. sites
- 31
- U.S. states
- 26
- U.S. cities
- 31
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama Birmingham | Birmingham | Alabama | 35294 | Recruiting |
| Barrow Neurological Institute | Phoenix | Arizona | 85013 | Recruiting |
| University of California San Diego | La Jolla | California | 92037 | Recruiting |
| University of California Irvine | Orange | California | 92868 | Recruiting |
| University of California, San Francisco | San Francisco | California | 94143 | Recruiting |
| University of Colorado Anschutz Medical Campus | Aurora | Colorado | 80045 | Recruiting |
| Hospital for Special Care | New Britain | Connecticut | 06053 | Recruiting |
| Georgetown University | Washington D.C. | District of Columbia | 200007 | Recruiting |
| Mayo Clinic | Jacksonville | Florida | 32224 | Recruiting |
| Saint Alphonsus Regional Medical Center | Boise | Idaho | 83704 | Recruiting |
| Northwestern University | Chicago | Illinois | 60611 | Recruiting |
| Indiana University | Indianapolis | Indiana | 46202 | Recruiting |
| John Hopkins University | Baltimore | Maryland | 21205 | Recruiting |
| Nih/Ninds | Bethesda | Maryland | 20892 | Recruiting |
| Massachusetts General Brigham | Boston | Massachusetts | 02145 | Recruiting |
| University of Michigan | Ann Arbor | Michigan | 48109 | Recruiting |
| Henry Ford Health | Detroit | Michigan | 48202 | Recruiting |
| University of Minnesota | Minneapolis | Minnesota | 55455 | Recruiting |
| Washington University | St Louis | Missouri | 63110 | Recruiting |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198 | Recruiting |
| Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | Recruiting |
| Columbia University | New York | New York | 10032 | Recruiting |
| Duke University | Durham | North Carolina | 27705 | Recruiting |
| Ohio State University | Columbus | Ohio | 43221 | Recruiting |
| Providence ALS Center | Portland | Oregon | 97213 | Recruiting |
| Penn State Health | Hershey | Pennsylvania | 17033 | Recruiting |
| Temple University | Philadelphia | Pennsylvania | 19140 | Recruiting |
| Texas Neurology | Dallas | Texas | 75206 | Recruiting |
| University of Utah | Salt Lake City | Utah | 84132 | Recruiting |
| Virginia Commonwealth University | Richmond | Virginia | 23298 | Recruiting |
| University of Washington | Seattle | Washington | 98195 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06581861, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 24, 2026 · Synced Oct 7, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06581861 live on ClinicalTrials.gov.