Study of Intralesional Cemiplimab in Adult Patients With Early Stage Cutaneous Squamous Cell Carcinoma

ClinicalTrials.gov ID: NCT06585410

Public ClinicalTrials.gov record NCT06585410. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Apr 29, 2026, 8:57 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3 Randomized Study of Intralesional Cemiplimab Versus Primary Surgery in Participants With Early Stage Cutaneous Squamous Cell Carcinoma (CSCC)

Study identification

NCT ID: NCT06585410
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Regeneron Pharmaceuticals; Industry
Enrollment: 369 participants

Conditions and interventions

Conditions

Cutaneous Squamous Cell Carcinoma (CSCC)

Interventions

Cemiplimab Drug
Standard of care Procedure

Drug · Procedure

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jan 1, 2025
Primary completion: May 2, 2030
Completion: May 2, 2030
Last update posted: Apr 21, 2026

2025 – 2030

United States locations

U.S. sites: 44
U.S. states: 24
U.S. cities: 43

Facility	City	State	ZIP	Site status
Medical Dermatology Specialists	Phoenix	Arizona	85006	Recruiting
Mayo Clinic - Arizona	Scottsdale	Arizona	85259	Recruiting
University of Arizona Cancer Center	Tucson	Arizona	85719	Recruiting
Arkansas Research Trials	North Little Rock	Arkansas	72117	Recruiting
UC San Diego Moores Cancer Center	La Jolla	California	92093	Recruiting
Stanford University	Redwood City	California	94063	Recruiting
Peak Dermatology, Aesthetics and Wellness	Visalia	California	93291	Recruiting
George Washington University Medical Faculty Associates	Washington D.C.	District of Columbia	20037	Recruiting
Life Clinical Trials	Coral Springs	Florida	33071	Recruiting
Dermatology Associates of the Palm Beaches	Delray Beach	Florida	33445	Recruiting
University of South Florida	Tampa	Florida	33612	Recruiting
University of Chicago Medical Center	Chicago	Illinois	60637	Recruiting
Oak Dermatology	Naperville	Illinois	60563	Recruiting
Dawes Fretzin Clinical Research - Shadeland Ave.	Indianapolis	Indiana	46250	Withdrawn
Equity Medical, LLC	Bowling Green	Kentucky	42104	Recruiting
US Dermatology Partners DBA DermAssociates, PC	Rockville	Maryland	20850	Recruiting
Northeast Dermatology Associates	Beverly	Massachusetts	01915	Recruiting
Dana-Farber Cancer Institute	Boston	Massachusetts	02215	Recruiting
MyMichigan Dermatologic Oncology	Midland	Michigan	48640	Recruiting
Somerset Skin Centre	Troy	Michigan	48084	Recruiting
Dermatology and Skin Cancer Center	Lee's Summit	Missouri	64064	Recruiting
Washington University in St. Louis - Center for Dermatologic and Cosmetic Surgery	St Louis	Missouri	63141	Recruiting
Las Vegas Dermatology	Las Vegas	Nevada	89144	Recruiting
Metropolitan Dermatology	Clark	New Jersey	07066	Recruiting
University of New Mexico	Albuquerque	New Mexico	87102	Recruiting
Memorial Sloan Kettering Cancer Center	New York	New York	10021	Recruiting
Columbia University Medical Center - Herbert Irving Center for Dermatology and Skin Cancer - Herbert Irving Pavilion	New York	New York	10032	Recruiting
Rochester Dermatologic Surgery, P.C.	Victor	New York	14564	Recruiting
UNC Hospitals Dermatology and Skin Cancer Center at Southern Village	Chapel Hill	North Carolina	27516	Recruiting
Cleveland Clinic	Cleveland	Ohio	44195	Recruiting
Buckeye Dermatology - Springfield Office	Springfield	Ohio	45505	Recruiting
University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	73104	Recruiting
Dermatology Health Specialists	Bend	Oregon	97702	Recruiting
Oregon Health & Science University	Portland	Oregon	97239	Recruiting
Penn State Hershey Medical Center	Hershey	Pennsylvania	17033	Recruiting
Hospital of the University of Pennsylvania	Philadelphia	Pennsylvania	19104	Recruiting
Clinical Research Center of the Carolinas	Charleston	South Carolina	29407	Recruiting
The University of Texas at Austin Dell Medical School Ascension Medical Group	Austin	Texas	78701	Recruiting
Reveal Research Institute	Dallas	Texas	75235	Recruiting
The University of Texas MD Anderson Cancer Center	Houston	Texas	77030	Recruiting
Epiphany Dermatology	Lewisville	Texas	75056	Recruiting
Texas Dermatology and Laser Specialists	San Antonio	Texas	78218	Recruiting
Center for Clinical Studies at Webster Clear Lake	Webster	Texas	77598	Recruiting
University of Utah Hospital	Salt Lake City	Utah	84132	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 5 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06585410, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 21, 2026 · Synced Apr 29, 2026

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The complete protocol, eligibility criteria, and contact information for NCT06585410 live on ClinicalTrials.gov.

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