Study of Intralesional Cemiplimab in Adult Patients With Early Stage Cutaneous Squamous Cell Carcinoma
Public ClinicalTrials.gov record NCT06585410. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3 Randomized Study of Intralesional Cemiplimab Versus Primary Surgery in Participants With Early Stage Cutaneous Squamous Cell Carcinoma (CSCC)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will test a study drug called cemiplimab to see if it can help treat early-stage Cutaneous Squamous Cell Carcinoma (CSCC), a type of skin cancer. Cemiplimab works by helping the immune system to kill cancer cells. It binds to a protein called Programmed cell Death-1 (PD-1) on the surface of certain immune cells. The main purpose of this study is to compare how well cemiplimab works compared to surgery, when injected into the lesion. The study is looking at: * The side effects cemiplimab might cause * How well cemiplimab works compared to surgery
Study identification
- NCT ID
- NCT06585410
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 369 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 1, 2025
- Primary completion
- May 2, 2030
- Completion
- May 2, 2030
- Last update posted
- Aug 16, 2026
2025 – 2030
United States locations
- U.S. sites
- 47
- U.S. states
- 26
- U.S. cities
- 46
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Medical Dermatology Specialists - Phoenix | Phoenix | Arizona | 85006 | Recruiting |
| Mayo Clinic - Arizona | Scottsdale | Arizona | 85259 | Recruiting |
| University of Arizona Cancer Center | Tucson | Arizona | 85719 | Recruiting |
| Arkansas Research Trials | North Little Rock | Arkansas | 72117 | Recruiting |
| UC San Diego Moores Cancer Center | La Jolla | California | 92093 | Recruiting |
| Profound Research, Dermatology Medical Group - Oceanside | Oceanside | California | 92056 | Recruiting |
| Stanford University | Redwood City | California | 94063 | Recruiting |
| Peak Dermatology, Aesthetics and Wellness | Visalia | California | 93291 | Recruiting |
| George Washington University Medical Faculty Associates | Washington D.C. | District of Columbia | 20037 | Recruiting |
| Life Clinical Trials | Coral Springs | Florida | 33071 | Recruiting |
| Dermatology Associates of the Palm Beaches, Integri Research at Dermatology Associates | Delray Beach | Florida | 33445 | Recruiting |
| University of South Florida | Tampa | Florida | 33612 | Recruiting |
| University of Chicago Medical Center | Chicago | Illinois | 60637 | Recruiting |
| Oak Dermatology | Naperville | Illinois | 60563 | Recruiting |
| Dawes Fretzin Clinical Research - Shadeland Ave. | Indianapolis | Indiana | 46250 | Withdrawn |
| Equity Medical, LLC | Bowling Green | Kentucky | 42104 | Withdrawn |
| US Dermatology Partners DBA DermAssociates, PC | Rockville | Maryland | 20850 | Recruiting |
| Northeast Dermatology Associates | Beverly | Massachusetts | 01915 | Recruiting |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02215 | Recruiting |
| MyMichigan Dermatologic Oncology | Midland | Michigan | 48640 | Recruiting |
| Somerset Skin Centre | Troy | Michigan | 48084 | Recruiting |
| Dermatology and Skin Cancer Center | Lee's Summit | Missouri | 64064 | Recruiting |
| Washington University in St. Louis - Center for Dermatologic and Cosmetic Surgery | St Louis | Missouri | 63141 | Recruiting |
| Las Vegas Dermatology | Las Vegas | Nevada | 89144 | Recruiting |
| StracSkin, PLLC | Portsmouth | New Hampshire | 03801 | Recruiting |
| Metropolitan Dermatology | Clark | New Jersey | 07066 | Withdrawn |
| University of New Mexico | Albuquerque | New Mexico | 87102 | Recruiting |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10021 | Recruiting |
| Columbia University Medical Center - Herbert Irving Center for Dermatology and Skin Cancer - Herbert Irving Pavilion | New York | New York | 10032 | Recruiting |
| Rochester Dermatologic Surgery, P.C. | Victor | New York | 14564 | Recruiting |
| UNC Hospitals Dermatology and Skin Cancer Center at Southern Village | Chapel Hill | North Carolina | 27516 | Recruiting |
| Cleveland Clinic | Cleveland | Ohio | 44195 | Recruiting |
| Buckeye Dermatology - Springfield Office | Springfield | Ohio | 45505 | Recruiting |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | Recruiting |
| Dermatology Health Specialists | Bend | Oregon | 97702 | Recruiting |
| Oregon Health & Science University | Portland | Oregon | 97239 | Recruiting |
| Penn State Hershey Medical Center | Hershey | Pennsylvania | 17033 | Recruiting |
| Penn Medicine, Perelman Center For Advanced Medicine | Philadelphia | Pennsylvania | 19104 | Recruiting |
| Clinical Research Center of the Carolinas | Charleston | South Carolina | 29407 | Recruiting |
| The University of Texas at Austin Dell Medical School Ascension Medical Group | Austin | Texas | 78701 | Recruiting |
| Reveal Research Institute | Dallas | Texas | 75235 | Recruiting |
| The University of Texas MD Anderson Cancer Center | Houston | Texas | 77030 | Recruiting |
| Epiphany Dermatology | Lewisville | Texas | 75056 | Recruiting |
| Texas Dermatology and Laser Specialists | San Antonio | Texas | 78218 | Recruiting |
| Center for Clinical Studies at Webster Clear Lake | Webster | Texas | 77598 | Recruiting |
| University of Utah Hospital | Salt Lake City | Utah | 84132 | Recruiting |
| Vcu Massey Cancer Center | Richmond | Virginia | 23298 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 5 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06585410, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 16, 2026 · Synced Sep 1, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06585410 live on ClinicalTrials.gov.