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Recruiting Phase 3 Interventional

A Study to Evaluate Axatilimab and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease

ClinicalTrials.gov ID: NCT06585774

Public ClinicalTrials.gov record NCT06585774. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 10, 2026, 9:42 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Axatilimab and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease (AXemplify-357)

Study identification

NCT ID
NCT06585774
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
Incyte Corporation
Industry
Enrollment
240 participants

Conditions and interventions

Interventions

  • Corticosteroids Drug
  • INCA034176 Drug
  • Placebo Drug

Drug

Eligibility (public fields only)

Age range
12 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jan 20, 2025
Primary completion
Sep 27, 2027
Completion
Mar 30, 2030
Last update posted
May 7, 2026

2025 – 2030

United States locations

U.S. sites
32
U.S. states
22
U.S. cities
31
Facility City State ZIP Site status
University of Alabama Birmingham Birmingham Alabama 35294 Recruiting
University of California San Diego Medical Center, Moores Cancer Center La Jolla California 92037 Recruiting
University of Southern California Los Angeles California 90089 Recruiting
Colorado Blood Cancer Institute Denver Colorado 80218 Recruiting
Childrens National Hospital Washington D.C. District of Columbia 20010 Recruiting
Miami Cancer Institute Miami Florida 33176 Recruiting
Orlando Health Cancer Institute Downtown Orlando Orlando Florida 32806 Recruiting
Memorial Cancer Institute Pembroke Pines Florida 33026 Recruiting
Emory University-Winship Cancer Institute Atlanta Georgia 30322 Recruiting
University of Illinois Chicago Illinois 60612 Recruiting
The University of Kansas Cancer Center Kansas City Kansas 66160 Recruiting
John Hopkins Hospital Baltimore Maryland 21287 Recruiting
Massachusetts General Hospital Boston Massachusetts 02114 Recruiting
Dana Farber Cancer Institute Boston Massachusetts 02215 Recruiting
University of Michigan Ann Arbor Michigan 48109 Recruiting
Henry Ford Hospital Detroit Michigan 48202 Recruiting
Corewell Health Hematology Oncology Grand Rapids Michigan 49503 Recruiting
Hackensack University Medical Center Hackensack New Jersey 07601 Recruiting
Rutgers Cancer Institute of Nj New Brunswick New Jersey 08903 Recruiting
University of Rochester Medical Center Rochester New York 14642 Recruiting
Stony Brook University Medical Center Stony Brook New York 11794 Recruiting
Wake Forest Baptist Medical Center Winston-Salem North Carolina 27157 Recruiting
Oregon Health and Science University Portland Oregon 97239 Recruiting
Jefferson University Hospitals Philadelphia Pennsylvania 19107 Recruiting
Medical University of South Carolina Charleston South Carolina 29425 Recruiting
Prisma Health Upstate Greenville South Carolina 29615 Recruiting
Baptist Cancer Center Memphis Tennessee 38120 Recruiting
St David'S South Austin Medical Center Austin Texas 78704 Recruiting
Texas Transplant Institute San Antonio Texas 78229 Recruiting
Intermountain Blood and Marrow Transplant Salt Lake City Utah 84143 Recruiting
Virginia Commonwealth University Massey Cancer Center Richmond Virginia 23298 Recruiting
West Virginia University Cancer Institute Morgantown West Virginia 26506 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 87 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT06585774, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted May 7, 2026 · Synced May 10, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06585774 live on ClinicalTrials.gov.

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