ClinicalTrials.gov record
A Study to Assess the Efficacy and Safety of Afimkibart (Also Known as RO7790121) for Induction and Maintenance Therapy in Participants With Moderately to Severely Active Ulcerative Colitis
ClinicalTrials.gov ID: NCT06589986
Public ClinicalTrials.gov record NCT06589986. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 8, 2026, 4:17 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III, Multicenter, Double-Blind, Placebo-Controlled, Treat-Through Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy With RO7790121 in Patients With Moderately to Severely Active Ulcerative Colitis
Study identification
- NCT ID
- NCT06589986
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Hoffmann-La Roche
- Industry
- Enrollment
- 400 participants
Conditions and interventions
Interventions
- Afimkibart Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 16 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 16, 2024
- Primary completion
- Jan 29, 2027
- Completion
- Jan 29, 2031
- Last update posted
- Mar 18, 2026
2024 – 2031
United States locations
- U.S. sites
- 79
- U.S. states
- 27
- U.S. cities
- 71
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Digestive Health Specialists of the Southeast (Gastroenterology Associates of Dothan) - Dothan | Dothan | Alabama | 36305 | — |
| Arizona Digestive Health, P.C (ADH) | Sun City | Arizona | 85351 | — |
| Om Research LLC | Lancaster | California | 93534 | — |
| UCLA | Los Angeles | California | 90095 | — |
| University of California Irvine | Orange | California | 92868 | — |
| Stanford Medicine Outpatient Center | Redwood City | California | 94063 | — |
| Acclaim Clinical Research, Inc. | San Diego | California | 92120 | — |
| UCSF/Medical Center at Mount Zion | San Francisco | California | 94115 | — |
| Amicis Research Center | Santa Clarita | California | 91355 | — |
| Peak Gastroenterology Associates | Colorado Springs | Colorado | 80907 | — |
| Peak Gastroenterology Surgery Center | Lone Tree | Colorado | 80124 | — |
| Access Research Institute | Brooksville | Florida | 34613 | — |
| Gastro Florida | Clearwater | Florida | 33756 | — |
| HealthMed Clinical Center Inc. | Coral Gables | Florida | 33134 | — |
| J&A Clinical Research | Doral | Florida | 33126 | — |
| Clinical Research of Osceola, LLC | Kissimmee | Florida | 34741 | — |
| Auzmer Research | Lakeland | Florida | 33813 | — |
| Florida Research Institute - Lakewood | Lakewood Rch | Florida | 34211 | — |
| Homestead Associates in Research, Inc. | Miami | Florida | 33033 | — |
| Allied Biomedical Research Institute, Inc | Miami | Florida | 33155 | — |
| Miami Beach Clinical Research Center | Miami Beach | Florida | 33141 | — |
| Eminat Research Group | Miramar | Florida | 33027 | — |
| Orlando Regional Healthcare | Orlando | Florida | 32806 | — |
| Nodal Medical Center, LLC | Tampa | Florida | 33607 | — |
| Theia Clinical Research Centers, LLC | Tampa | Florida | 33613 | — |
| Cleveland Clinic Florida | Weston | Florida | 33331 | — |
| Florida Medical Clinic | Zephyrhills | Florida | 33542 | — |
| Gastroenterology Associates of Central Georgia | Macon | Georgia | 31201 | — |
| Grand Teton Research Group, PLLC | Idaho Falls | Idaho | 83404 | — |
| Northwestern Memorial Hospital | Chicago | Illinois | 60611 | — |
| Next Innovative Clinical Research | Chicago | Illinois | 60616 | — |
| The University of Chicago | Chicago | Illinois | 60637 | — |
| Indiana University Health University Hospital | Indianapolis | Indiana | 46202 | — |
| Gastroenterology Health Partners, PLLC | New Albany | Indiana | 47150 | — |
| Tri-State Gastroenterology Associates | Crestview Hills | Kentucky | 41017-3409 | — |
| Robley Rex VA Medical Center | Louisville | Kentucky | 40206 | — |
| Gastroenterology Health Partners, PLLC | Louisville | Kentucky | 40218 | — |
| Louisiana Research Center - GastroIntestinal Associates | Shreveport | Louisiana | 71105 | — |
| Brigham & Womens Hosp | Boston | Massachusetts | 02115 | — |
| Boston University | Boston | Massachusetts | 02118 | — |
| Michigan Center of Medical Research | Farmington Hills | Michigan | 48334 | — |
| Allied Gastrointestinal Associates, PA | Flowood | Mississippi | 39232 | — |
| BVL Clinical Research | Liberty | Missouri | 64068 | — |
| Las Vegas Clinical Trials, LLC | North Las Vegas | Nevada | 89030 | — |
| Intercity Gastroenterology | Fresh Meadows | New York | 11366 | — |
| Northwell Health Physician Partners Gastroenterology at Great Neck | Great Neck | New York | 11021 | — |
| Pioneer Clinical Research NY | New York | New York | 10016 | — |
| Mainstreet - Richmond Hill Clinic | Richmond Hill | New York | 11418 | — |
| Digestive Health Partners, PA | Asheville | North Carolina | 28801 | — |
| Peters Medical Research (PMR), LLC | High Point | North Carolina | 27260 | — |
| Monroe Biomedical Research | Monroe | North Carolina | 28112 | — |
| Digestive Disease Consultants | Brunswick | Ohio | 44212 | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| Ohio Gastroenterology Group | Columbus | Ohio | 43202 | — |
| Great Lakes Gastroenterology Research, LLC | Mentor | Ohio | 44060 | — |
| Gastro Intestinal Research Institute of Northern Ohio | Westlake | Ohio | 44145 | — |
| University Gastroenterology | Providence | Rhode Island | 02904 | — |
| Medical University of South Carolina (MUSC) | Charleston | South Carolina | 29425 | — |
| Gastro One | Cordova | Tennessee | 38018 | — |
| Gastrointestinal Associates of Northeast Tennessee | Johnson City | Tennessee | 37604 | — |
| Quality Medical Research | Nashville | Tennessee | 37211 | — |
| Texas Digestive Disease Consultants - Cedar Park | Cedar Park | Texas | 78613 | — |
| The University of Texas Southwestern Medical Center at Dallas | Dallas | Texas | 75390 | — |
| Proactive El Paso,LLC | El Paso | Texas | 79902 | — |
| GI Alliance | Garland | Texas | 75044 | — |
| Baylor College of Medicine. | Houston | Texas | 77030 | — |
| TDDC dba GI Alliance Research | Mansfield | Texas | 76063 | — |
| SMS Clinical Research, LLC | Mesquite | Texas | 75149 | — |
| Digestive System Healthcare - Biopharma Informatic, LLC | Pasadena | Texas | 77505-3950 | — |
| Carta - Clinical Associates In Research Therapeutics Of America;LLC | San Antonio | Texas | 78212 | — |
| Southern Star Research Institute, LLC. | San Antonio | Texas | 78229 | — |
| GI Alliance - Southlake | Southlake | Texas | 76092 | — |
| Tyler Research Institute, LLC | Tyler | Texas | 75701 | — |
| University of Texas Health Center at Tyler | Tyler | Texas | 75708 | — |
| Tidewater Gastroenterology Pllc T/A Gastro. Assoc. of Tidewater | Chesapeake | Virginia | 23320 | — |
| Gastroenterology Consultants of SWVA | Roanoke | Virginia | 24018 | — |
| The Vancouver Clinic | Vancouver | Washington | 98664 | — |
| Marshall Health | Huntington | West Virginia | 25701 | — |
| Univ of Wisconsin Hosp & Clin | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 150 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06589986, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 18, 2026 · Synced May 8, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06589986 live on ClinicalTrials.gov.