A Study to Assess the Efficacy and Safety of Afimkibart (Also Known as RO7790121) for Induction and Maintenance Therapy in Participants With Moderately to Severely Active Ulcerative Colitis
Public ClinicalTrials.gov record NCT06589986. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III, Multicenter, Double-Blind, Placebo-Controlled, Treat-Through Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy With RO7790121 in Patients With Moderately to Severely Active Ulcerative Colitis
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This Phase III, multicenter, double-blind, placebo-controlled, treat-through study will evaluate the efficacy and safety of Afimkibart (RO7790121) compared with placebo in participants with moderately to severely active ulcerative colitis (UC).
Study identification
- NCT ID
- NCT06589986
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 400 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 16 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 17, 2024 (Actual)
- Primary completion
- Jan 30, 2027 (Estimated)
- Completion
- Jan 30, 2031 (Estimated)
- Last update posted
- Sep 14, 2026
2024 – 2031
United States locations
- U.S. sites
- 46
- U.S. states
- 20
- U.S. cities
- 42
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Digestive Health Specialists of the Southeast (Gastroenterology Associates of Dothan) - Dothan | Dothan | Alabama | 36305 | — |
| Om Research LLC | Lancaster | California | 93534 | — |
| University of California Irvine | Orange | California | 92868 | — |
| Peak Gastroenterology Associates | Colorado Springs | Colorado | 80907 | — |
| Access Research Institute | Brooksville | Florida | 34613 | — |
| Gastro Florida | Clearwater | Florida | 33756 | — |
| Clinical Research of Osceola, LLC | Kissimmee | Florida | 34741 | — |
| Auzmer Research | Lakeland | Florida | 33813 | — |
| Florida Research Institute - Lakewood | Lakewood Rch | Florida | 34211 | — |
| Homestead Associates in Research, Inc. | Miami | Florida | 33033 | — |
| Allied Biomedical Research Institute, Inc | Miami | Florida | 33155 | — |
| Miami Beach Clinical Research Center | Miami Beach | Florida | 33141 | — |
| Theia Clinical Research Centers, LLC | Tampa | Florida | 33613 | — |
| Florida Medical Clinic | Zephyrhills | Florida | 33542 | — |
| Gastroenterology Associates of Central Georgia | Macon | Georgia | 31201 | — |
| Grand Teton Research Group, PLLC | Idaho Falls | Idaho | 83404 | — |
| The University of Chicago | Chicago | Illinois | 60637 | — |
| Indiana University Health University Hospital | Indianapolis | Indiana | 46202 | — |
| Gastroenterology Health Partners, PLLC | New Albany | Indiana | 47150 | — |
| Tri-State Gastroenterology Associates | Crestview Hills | Kentucky | 41017-3409 | — |
| Gastroenterology Health Partners, PLLC | Louisville | Kentucky | 40218 | — |
| Louisiana Research Center - GastroIntestinal Associates | Shreveport | Louisiana | 71105 | — |
| Brigham & Womens Hosp | Boston | Massachusetts | 02115 | — |
| Boston University | Boston | Massachusetts | 02118 | — |
| Allied Gastrointestinal Associates, PA | Flowood | Mississippi | 39232 | — |
| Intercity Gastroenterology | Fresh Meadows | New York | 11366 | — |
| Pioneer Clinical Research NY | New York | New York | 10016 | — |
| Digestive Health Partners, PA | Asheville | North Carolina | 28801 | — |
| Peters Medical Research (PMR), LLC | High Point | North Carolina | 27260 | — |
| Monroe Biomedical Research | Monroe | North Carolina | 28112 | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| Ohio Gastroenterology Group | Columbus | Ohio | 43202 | — |
| Gastro Intestinal Research Institute of Northern Ohio | Westlake | Ohio | 44145 | — |
| University Gastroenterology | Providence | Rhode Island | 02904 | — |
| Medical University of South Carolina (MUSC) | Charleston | South Carolina | 29425 | — |
| Gastro One | Cordova | Tennessee | 38018 | — |
| Gastrointestinal Associates of Northeast Tennessee | Johnson City | Tennessee | 37604 | — |
| The University of Texas Southwestern Medical Center at Dallas | Dallas | Texas | 75390 | — |
| GI Alliance | Garland | Texas | 75044 | — |
| TDDC dba GI Alliance Research | Mansfield | Texas | 76063 | — |
| Carta - Clinical Associates In Research Therapeutics Of America;LLC | San Antonio | Texas | 78212 | — |
| Southern Star Research Institute, LLC. | San Antonio | Texas | 78229 | — |
| Tyler Research Institute, LLC | Tyler | Texas | 75701 | — |
| University of Texas Health Center at Tyler | Tyler | Texas | 75708 | — |
| Tidewater Gastroenterology Pllc T/A Gastro. Assoc. of Tidewater | Chesapeake | Virginia | 23320 | — |
| Gastroenterology Consultants of SWVA | Roanoke | Virginia | 24018 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 138 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06589986, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 14, 2026 · Synced Oct 19, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06589986 live on ClinicalTrials.gov.