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Recruiting Phase 1Phase 2 Interventional

Trial of 225Ac-DOTATATE (RYZ101) in Subjects With ER+, HER2-negative Unresectable or Metastatic Breast Cancer Expressing SSTRs.

ClinicalTrials.gov ID: NCT06590857

Public ClinicalTrials.gov record NCT06590857. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Oct 17, 2026, 12:47 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Phase 1b/2 Open-label Trial of 225Ac-DOTATATE (RYZ101) in Subjects With Estrogen Receptor-positive (ER+), Human Epidermal Growth Factor Receptor 2 (HER2)-Negative, Locally Advanced and Unresectable or Metastatic Breast Cancer Expressing Somatostatin Receptors (SSTRs) (TRACY-1).

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

Phase 1b/2 open-label trial of 225Ac-DOTATATE (RYZ101) in subjects with ER+, HER2-negative unresectable or metastatic breast cancer expressing SSTRs.

Study identification

NCT ID
NCT06590857
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 1, Phase 2
Lead sponsor
RayzeBio, Inc.
Industry
Enrollment
64 participants

Conditions and interventions

Eligibility (public fields only)

Age range
Not listed
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jul 19, 2024 (Actual)
Primary completion
Oct 2028 (Estimated)
Completion
Nov 2033 (Estimated)
Last update posted
Oct 6, 2026

2024 – 2033

United States locations

U.S. sites
25
U.S. states
19
U.S. cities
24
Facility City State ZIP Site status
Research Facility Phoenix Arizona 85054 Not yet recruiting
Research Facility Irvine California 92618 Not yet recruiting
Research Facility San Diego California 92093 Not yet recruiting
Research Facility Santa Monica California 90404 Not yet recruiting
Research Facility Longmont Colorado 80504 Not yet recruiting
Research Facility Jacksonville Florida 32224 Not yet recruiting
Research Facility Atlanta Georgia 30322 Not yet recruiting
Research Facility Indianapolis Indiana 46202 Not yet recruiting
Research Facility Boston Massachusetts 02215 Not yet recruiting
Research Facility Detroit Michigan 48202 Not yet recruiting
Research Facility Rochester Minnesota 55905 Not yet recruiting
Research Facility St Louis Missouri 63130 Not yet recruiting
Research Facility Omaha Nebraska 68124 Recruiting
Research Facility Albuquerque New Mexico 87109 Not yet recruiting
Research Facility Buffalo New York 14203 Not yet recruiting
Research Facility New York New York 10016 Not yet recruiting
Research Facility New York New York 10021 Not yet recruiting
Research Facility Cleveland Ohio 44195 Not yet recruiting
Research Facility Philadelphia Pennsylvania 19104 Not yet recruiting
Research Facility Pittsburgh Pennsylvania 15213 Not yet recruiting
Research Facility Dallas Texas 75246 Not yet recruiting
Research Facility Houston Texas 77024 Not yet recruiting
Research Facility Salt Lake City Utah 84132 Not yet recruiting
Research Facility Norfolk Virginia 23502 Not yet recruiting
Research Facility Seattle Washington 98109 Not yet recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 6 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT06590857, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Oct 6, 2026 · Synced Oct 17, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT06590857 live on ClinicalTrials.gov.

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