A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or Thalassaemia

ClinicalTrials.gov ID: NCT06609226

Public ClinicalTrials.gov record NCT06609226. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 28, 2026, 5:52 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

An Open-label, Multi-centre, Rollover Study to Characterise Long-term Safety and Efficacy of Etavopivat in Adults, Adolescents and Children Who Have Sickle Cell Disease or Thalassaemia and Have Completed a Treatment Period in an Etavopivat Study

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

Etavopivat is a new medicine under development for treating blood disorders like sickle cell disease and thalassaemia. Sickle cell disease and thalassaemia are inherited blood disorders that affect haemoglobin. Haemoglobin is the protein that carries oxygen through the body. This study is looking into how safe treatment with etavopivat is and how well it works over a long period of time. The study will last for up to 264 weeks, but it will end earlier if etavopivat is approved in the participant's country.

Study identification

NCT ID: NCT06609226
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Novo Nordisk A/S; Industry
Enrollment: 480 participants

Conditions and interventions

Conditions

Interventions

Drug

Eligibility (public fields only)

Age range: 2 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jan 9, 2025
Primary completion: Dec 29, 2030
Completion: Dec 29, 2030
Last update posted: Sep 17, 2026

2025 – 2030

United States locations

U.S. sites: 36
U.S. states: 20
U.S. cities: 30

Facility	City	State	ZIP	Site status
Univ of Alabama Birmingham	Birmingham	Alabama	35233	Active, not recruiting
Phoenix Children's Hsptl	Phoenix	Arizona	85016	Active, not recruiting
Children's Hospital Los Angeles - Endocrinology	Los Angeles	California	90027	Recruiting
UCSF Oakland Benioff ChildHosp	Oakland	California	94609	Recruiting
Children's Hosp Of Orange	Orange	California	92868	Completed
University Of California Irvine	Orange	California	92868	Active, not recruiting
University of Connecticut	Farmington	Connecticut	06030	Active, not recruiting
Children's National Medical Center	Washington D.C.	District of Columbia	20010	Completed
Foundation for Sickle Cell Disease Research	Hollywood	Florida	33023	Active, not recruiting
Univ of Miami/SCCC	Miami	Florida	33136	Completed
Emory University School of Medicine	Atlanta	Georgia	30303	Active, not recruiting
Children's Healthcare Atlanta	Atlanta	Georgia	30329	Recruiting
Center for Blood Disorders Augusta University	Augusta	Georgia	30912	Active, not recruiting
Univer Of Illinois at Chicago	Chicago	Illinois	60612	Recruiting
Children's Hosp-New Orleans	New Orleans	Louisiana	70118	Completed
Boston Medical Center	Boston	Massachusetts	02118	Active, not recruiting
Washington University-St.Louis	St Louis	Missouri	63110	Active, not recruiting
NYC Health+Hospitals	Brooklyn	New York	11203	Active, not recruiting
Columbia University Medical Center_New York_0	New York	New York	10032	Not yet recruiting
Weill Cornell Med Coll-NYPH	New York	New York	10065	Active, not recruiting
Jacobi Medical Center	The Bronx	New York	10461	Active, not recruiting
Montefiore Medical Center	The Bronx	New York	10467	Active, not recruiting
Atrium Levine Children's/Atrium Health	Charlotte	North Carolina	28204	Not yet recruiting
Duke University_Durham	Durham	North Carolina	27710	Recruiting
East Carolina Univ-Greenville	Greenville	North Carolina	27834	Active, not recruiting
East Carolina University_Greenville	Greenville	North Carolina	27834	Completed
Atrium Health-Wake Forest Bapt	Winston-Salem	North Carolina	27157	Active, not recruiting
Cincinnati Child's Hsp Med Ctr	Cincinnati	Ohio	45229	Active, not recruiting
Neuro-Behavioral Clinical Research	North Canton	Ohio	44720	Active, not recruiting
Medical University Of South Carolina_Charleston	Charleston	South Carolina	29425	Active, not recruiting
Methodist University Hospital	Memphis	Tennessee	38104	Active, not recruiting
Texas Children's Hospital_Houston	Houston	Texas	77030	Recruiting
UT Health University of Texas	Houston	Texas	77030	Recruiting
Virginia Comm Univ Medical Ctr	Richmond	Virginia	23298	Completed
Mary Bridge Children's Health	Tacoma	Washington	98405	Active, not recruiting
Versiti, CCBD_Milwaukee	Milwaukee	Wisconsin	53226	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 65 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06609226, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Sep 17, 2026 · Synced Sep 28, 2026

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The complete protocol, eligibility criteria, and contact information for NCT06609226 live on ClinicalTrials.gov.

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