A Study Assessing Adverse Events and Disease Activity When Comparing Intravenously (IV) Infused ABBV-400 to Trifluridine and Tipiracil (LONSURF) Oral Tablets Plus IV Infused Bevacizumab in Adult Participants With c-Met Protein Above Cutoff Level Above Refractory Metastatic Colorectal Cancer
Public ClinicalTrials.gov record NCT06614192. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
AndroMETa-CRC-064: An Open Label, Randomized, Controlled, Global Phase 3 Study Comparing Telisotuzumab Adizutecan (ABBV-400) Monotherapy to LONSURF (Trifluridine and Tipiracil) Plus Bevacizumab in Subjects With Refractory Metastatic Colorectal Cancer Expressing c-Met Protein Level Above a Defined Cutoff
Study identification
- NCT ID
- NCT06614192
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- AbbVie
- Industry
- Enrollment
- 460 participants
Conditions and interventions
Conditions
Interventions
- Bevacizumab Drug
- Telisotuzumab Adizutecan Drug
- Trifluridine/Tipiracil Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 7, 2024
- Primary completion
- Sep 30, 2028
- Completion
- Sep 30, 2028
- Last update posted
- Aug 25, 2025
2024 – 2028
United States locations
- U.S. sites
- 24
- U.S. states
- 17
- U.S. cities
- 23
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| City of Hope National Medical Center /ID# 267875 | Duarte | California | 91010 | Recruiting |
| City of Hope - Orange County Lennar Foundation Cancer Center /ID# 270655 | Irvine | California | 92618 | Recruiting |
| USC Norris Comprehensive Cancer Center /ID# 268131 | Los Angeles | California | 90033 | Recruiting |
| Lutheran Medical Center- Cancer Centers of Colorado /ID# 268175 | Golden | Colorado | 80401 | Recruiting |
| Yale New Haven Hospital /ID# 269125 | New Haven | Connecticut | 06510 | Recruiting |
| AdventHealth Orlando /ID# 267970 | Orlando | Florida | 32803 | Recruiting |
| Winship Cancer Institute of Emory University /ID# 266884 | Atlanta | Georgia | 30322 | Recruiting |
| St. Luke's Cancer Institute: Boise /ID# 268095 | Boise | Idaho | 83712 | Recruiting |
| Northwestern Memorial Hospital /ID# 268610 | Chicago | Illinois | 60611-2927 | Recruiting |
| Hope And Healing Cancer Services /ID# 268541 | Hinsdale | Illinois | 60521 | Recruiting |
| Springfield Clinic - First /ID# 268666 | Springfield | Illinois | 62702 | Recruiting |
| Community Cancer Center North /ID# 267965 | Indianapolis | Indiana | 46250 | Recruiting |
| Hattiesburg Clinic /ID# 267860 | Hattiesburg | Mississippi | 39401 | Recruiting |
| Washington University /ID# 267872 | St Louis | Missouri | 63110 | Recruiting |
| Intermountain Health St. Vincent Regional Hospital - Cancer Centers of Montana /ID# 268185 | Billings | Montana | 59102 | Recruiting |
| Rutgers Cancer Institute of New Jersey /ID# 268056 | New Brunswick | New Jersey | 08901 | Recruiting |
| University of North Carolina Medical Center /ID# 266879 | Chapel Hill | North Carolina | 27514 | Recruiting |
| Duke University Medical Center /ID# 267966 | Durham | North Carolina | 27710 | Recruiting |
| Avera Cancer Institute - Sioux Falls /ID# 268074 | Sioux Falls | South Dakota | 57105 | Recruiting |
| West Cancer Center and Research Institute - Germantown /ID# 268619 | Germantown | Tennessee | 38138 | Recruiting |
| University of Texas - Southwestern Medical Center /ID# 268241 | Dallas | Texas | 75235 | Recruiting |
| The University of Texas MD Anderson Cancer Center /ID# 268098 | Houston | Texas | 77030 | Recruiting |
| Millennium Research & Clinical Development /ID# 268400 | Houston | Texas | 77090 | Completed |
| University of Virginia /ID# 268108 | Charlottesville | Virginia | 22908 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 27 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06614192, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 25, 2025 · Synced May 8, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06614192 live on ClinicalTrials.gov.