Study to Assess the Efficacy of Rina-S Compared to Treatment of Investigator's Choice in Participants With Platinum Resistant Ovarian Cancer
Public ClinicalTrials.gov record NCT06619236. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3 Randomized, Open-label Study of Rinatabart Sesutecan (Rina-S) Versus Treatment of Investigator's Choice (IC) in Patients With Platinum Resistant Ovarian Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This phase 3 study will be conducted in different countries all over the world. The purpose of this study is to compare how well Rina-S works against platinum-resistant ovarian cancer compared to chemotherapy drugs that are already approved and used for platinum-resistant ovarian cancer. Treatment in this study could be Rina-S or it could be 1 of 4 indicated chemotherapy agents that are considered standard medical care. There is an equal (50:50) chance of getting Rina-S or an approved chemotherapy agent as treatment in this study. No one will know what treatment they are assigned to until the first dose. All participants will receive active drug; no one will be given placebo.
Study identification
- NCT ID
- NCT06619236
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 584 participants
Conditions and interventions
Conditions
Interventions
- Rina-S Drug
- Paclitaxel Drug
- Topotecan Drug
- Pegylated liposomal doxorubicin (PLD) Drug
- Gemcitabine Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Female
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 7, 2025 (Actual)
- Primary completion
- Aug 18, 2026 (Actual)
- Completion
- Oct 2027 (Estimated)
- Last update posted
- Sep 28, 2026
2025 – 2027
United States locations
- U.S. sites
- 72
- U.S. states
- 32
- U.S. cities
- 63
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Alaska Women's Cancer Care | Anchorage | Alaska | 99508 | — |
| Arizona Center for Cancer Care (ACCC) - Biltmore | Scottsdale | Arizona | 85251 | — |
| University of Arizona Cancer Center - Research and Administration at Main Campus | Tucson | Arizona | 85724 | — |
| Providence Saint Joseph Medical Center - Roy and Patricia Disney Family Cancer Center | Burbank | California | 91505 | — |
| University of California San Diego Moores Cancer Center | La Jolla | California | 92093 | — |
| USCF Mission Bay | San Francisco | California | 94158 | — |
| Kaiser Permanente - Vallejo Medical Center | Vallejo | California | 94589 | — |
| UCHealth Cancer Care - Anschutz Medical Campus - University of Colorado Cancer Center | Aurora | Colorado | 80045 | — |
| Hartford Hospital | Hartford | Connecticut | 06106 | — |
| Yale School of Medicine | New Haven | Connecticut | 06510 | — |
| Norwalk Hospital | Norwalk | Connecticut | 06850 | — |
| SCRI - Florida Cancer Specialists - South Region Research Office | Fort Myers | Florida | 33901-8108 | — |
| Mount Sinai Comprehensive Cancer Center | Miami Beach | Florida | 33140 | — |
| Orlando Health Cancer Institute - Downtown Orlando | Orlando | Florida | 32806 | — |
| Sarasota Memorial Hospital | Sarasota | Florida | 34239 | — |
| SCRI - Florida Cancer Specialists - West Palm Beach | West Palm Beach | Florida | 33401 | — |
| Winship Cancer Institute of Emory University | Atlanta | Georgia | 30322 | — |
| Northside Hospital Atlanta | Atlanta | Georgia | 30342 | — |
| Augusta University Georgia Cancer Center | Augusta | Georgia | 30912 | — |
| Kapi'olani Medical Center for Women and Children | Honolulu | Hawaii | 96826 | — |
| Northwest Cancer Center - Dyer | Dyer | Indiana | 46311 | — |
| University of Kansas Cancer Center | Kansas City | Kansas | 66160 | — |
| HCA Midwest Health | Overland Park | Kansas | 66211 | — |
| St. Elizabeth Healthcare - Edgewood | Edgewood | Kentucky | 41017 | — |
| Baptist Health Lexington | Lexington | Kentucky | 40503 | — |
| Louisiana State University Health Sciences Center (LSU Health) - New Orleans | New Orleans | Louisiana | 70112 | — |
| Trials365, LLC (Gynecologic Oncology Associates-Shreveport) | Shreveport | Louisiana | 71103 | — |
| Maine Medical Center Cancer Institute- Scarborough | Scarborough | Maine | 04074-7172 | — |
| Holy Cross Health - Holy Cross Hospital | Silver Spring | Maryland | 20910 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02215 | — |
| Barbara Ann Karmanos Cancer Institute | Detroit | Michigan | 48201 | — |
| Corewell Health (Spectrum Health) | Grand Rapids | Michigan | 49503 | — |
| Saint Joseph Mercy Ann Arbor Hospital | Ypsilanti | Michigan | 48197 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68105 | — |
| Center of Hope | Reno | Nevada | 89511 | — |
| Holy Name Medical Center | Teaneck | New Jersey | 07666 | — |
| University of New Mexico Comprehensive Cancer Center | Albuquerque | New Mexico | 87131 | — |
| Roswell Park Comprehensive Cancer Center | Buffalo | New York | 14203 | — |
| Perlmutter Cancer Center - 38th Street | New York | New York | 10016 | — |
| Perlmutter Cancer Center at NYU Langone Hospital - Long Island | New York | New York | 10016 | — |
| Herbert Irving Comprehensive Cancer Center | New York | New York | 10032 | — |
| New York-Presbyterian - Weill Cornell Medical Center | New York | New York | 10065 | — |
| James P. Wilmot Cancer Center | Rochester | New York | 14642 | — |
| Duke Cancer Institute | Durham | North Carolina | 27705 | — |
| FirstHealth Outpatient Cancer Center | Pinehurst | North Carolina | 28374 | — |
| University of Cincinnati Medical Center | Cincinnati | Ohio | 45219 | — |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | — |
| MetroHealth Medical Center | Cleveland | Ohio | 44109 | — |
| Cleveland Clinic Main Campus | Cleveland | Ohio | 44195 | — |
| JamesCare Gynecologic Oncology at Mill Run | Hilliard | Ohio | 43026 | — |
| Legacy Good Samaritan Medical Center | Portland | Oregon | 97210 | — |
| USOR - Northwest Cancer Specialists, P.C. dba Compass Oncology - Rose Quarter Cancer Center | Portland | Oregon | 97227 | — |
| Oregon Health and Science University | Portland | Oregon | 97239 | — |
| St. Luke's University Health Network | Bethlehem | Pennsylvania | 18015 | — |
| Penn State Health Milton S. Hershey Medical Center | Hershey | Pennsylvania | 17033 | — |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111 | — |
| Allegheny Health Network - West Penn Hospital | Pittsburgh | Pennsylvania | 15224 | — |
| Jefferson Health - Asplundh Cancer Pavilion | Willow Grove | Pennsylvania | 19090 | — |
| Avera Cancer Institute | Sioux Falls | South Dakota | 57105 | — |
| SCRI Oncology Partners | Nashville | Tennessee | 37203 | — |
| USOR - Texas Oncology - Dallas Fort Worth (DFW) - Abilene | Abilene | Texas | 79606 | — |
| USOR - Texas Oncology - Dallas Fort Worth (DFW) - Austin Central | Austin | Texas | 78731 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| USOR - Texas Oncology - Dallas Fort Worth (DFW) - Fort Worth | Fort Worth | Texas | 76104 | — |
| Inova Schar Cancer Institute | Fairfax | Virginia | 22031 | — |
| USOR - Virginia Oncology Associates - Norfolk | Norfolk | Virginia | 23502 | — |
| Kadlec Clinic - Hematology and Oncology | Kennewick | Washington | 99336 | — |
| Fred Hutchinson Cancer Research Center | Seattle | Washington | 98109 | — |
| Providence Sacred Heart Medical Center | Spokane | Washington | 99204 | — |
| West Virginia University Cancer Institute | Morgantown | West Virginia | 26506-9600 | — |
| University of Wisconsin - Madison | Madison | Wisconsin | 53706 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 105 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06619236, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 28, 2026 · Synced Oct 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06619236 live on ClinicalTrials.gov.