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Recruiting Phase 1Phase 2 Interventional Accepts healthy volunteers

Study of XmAb942 in Healthy Participants and Participants With Ulcerative Colitis

ClinicalTrials.gov ID: NCT06619990

Public ClinicalTrials.gov record NCT06619990. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Oct 20, 2026, 2:26 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 1, Randomized, Double-Blind, Placebo-Controlled Study in Healthy Participants Followed by a Randomized, Double-Blind, Placebo-Controlled Phase 2 Study of XmAb942 in Participants With Moderate-To-Severe Active Ulcerative Colitis.

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The Phase 1 study described herein will evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of XmAb942 in healthy volunteers (Parts A and B). Part C of this study will be a Phase 2 study to evaluate XmAb942 in participants with ulcerative colitis (UC).

Study identification

NCT ID
NCT06619990
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 1, Phase 2
Lead sponsor
Xencor, Inc.
Industry
Enrollment
270 participants

Conditions and interventions

Interventions

Biological · Drug

Eligibility (public fields only)

Age range
18 Years to 75 Years
Sex
All
Healthy volunteers
Accepts healthy volunteers

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Oct 10, 2024 (Actual)
Primary completion
Dec 2027 (Estimated)
Completion
May 2030 (Estimated)
Last update posted
Sep 29, 2026

2024 – 2030

United States locations

U.S. sites
30
U.S. states
11
U.S. cities
28
Facility City State ZIP Site status
Xencor Investigative Site Scottsdale Arizona 85255 Recruiting
Xencor Investigative Site Palo Alto California 94301 Recruiting
Xencor Investigative Site Bradenton Florida 34209 Recruiting
Xencor Investigative Site Brandon Florida 33511 Recruiting
Xencor Investigative Site Jacksonville Florida 32258 Recruiting
Xencor Investigative Site Kissimmee Florida 34741 Recruiting
Xencor Investigative Site Margate Florida 33063 Recruiting
Xencor Investigative Site Palmetto Bay Florida 33176 Recruiting
Xencor Investigative Site Tampa Florida 33612 Recruiting
Xencor Investigative Site Tampa Florida 33613 Recruiting
Xencor Investigative Site Louisville Kentucky 40218 Recruiting
Xencor Investigative Site Oxford Mississippi 38655 Recruiting
Xencor Investigative Site Tupelo Mississippi 38801 Recruiting
Xencor Investigative Site Albany New York 12206 Recruiting
Xencor Investigative Site Rochester New York 14618 Recruiting
Xencor Investigative Site Raleigh North Carolina 27612 Recruiting
Xencor Investigative Site Beavercreek Ohio 45440 Recruiting
Xencor Investigative Site Cordova Tennessee 38018 Recruiting
Xencor Investigative Site Cedar Park Texas 78613 Recruiting
Xencor Investigative Site Denton Texas 76201 Recruiting
Xencor Investigative Site Garland Texas 75044 Recruiting
Xencor Investigative Site Georgetown Texas 78628 Recruiting
Xencor Investigative Site Houston Texas 77024 Recruiting
Xencor Investigative Site Houston Texas 77090 Recruiting
Xencor Investigative Site Kingwood Texas 77339 Recruiting
Xencor Investigative Site Lubbock Texas 79424 Recruiting
Xencor Investigative Site San Antonio Texas 78229 Recruiting
Xencor Investigative Site Tyler Texas 75701 Recruiting
Xencor Investigative Site Webster Texas 77598 Recruiting
Xencor Investigative Site Richmond Virginia 23229 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 68 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT06619990, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Sep 29, 2026 · Synced Oct 20, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT06619990 live on ClinicalTrials.gov.

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