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Recruiting Phase 1 Interventional

Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors

ClinicalTrials.gov ID: NCT06625775

Public ClinicalTrials.gov record NCT06625775. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 3, 2026, 3:17 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 1a/1b Open-Label Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of BBO-10203 in Subjects With Advanced Solid Tumors (The BREAKER-101 Study)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

First in human study to evaluate the safety, tolerability, and pharmacokinetics (PK) of BBO-10203, a PI3Kα:RAS breaker, alone and in combination with other anti-cancer agents in patients with advanced solid tumors.

Study identification

NCT ID
NCT06625775
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 1
Enrollment
392 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Oct 28, 2024
Primary completion
Oct 31, 2028
Completion
Oct 31, 2028
Last update posted
Jun 22, 2026

2024 – 2028

United States locations

U.S. sites
19
U.S. states
10
U.S. cities
16
Facility City State ZIP Site status
City of Hope Comprehensive Cancer Center Duarte California 91010 Recruiting
University of California Los Angeles Los Angeles California 90095 Recruiting
University of California San Diego Moores Cancer Center San Diego California 92093 Recruiting
UCSF Helen Diller Family Comprehensive Cancer Center San Francisco California 94158 Recruiting
Moffitt Cancer Center Tampa Florida 33612 Recruiting
Indiana University Simon Comprehensive Cancer Center Indianapolis Indiana 46202 Recruiting
Massachusetts General Hospital Boston Massachusetts 02114 Recruiting
Dana-Farber Cancer Insitute Boston Massachusetts 02215 Recruiting
St. Lukes Hospital of Kansas City Kansas City Missouri 64111 Recruiting
Washington University School of Medicine St Louis Missouri 63110 Recruiting
Columbia University Irving Medical Center New York New York 10032 Recruiting
Memorial Sloan Kettering Cancer Center New York New York 10065 Recruiting
SCRI Oncology Partners Nashville Tennessee 37203 Recruiting
SCRI at Mary Crowley Dallas Texas 75230 Recruiting
University of Texas Southwestern Medical Center Dallas Texas 75390 Recruiting
The University of Texas MD Anderson Cancer Center Houston Texas 77030 Recruiting
University of Texas San Antonio (UTSA) San Antonio Texas 78229 Recruiting
Fred Hutchinson Cancer Center Seattle Washington 98109 Recruiting
Wisconsin Institute for Medical Research Madison Wisconsin 53792 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 21 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT06625775, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Jun 22, 2026 · Synced Sep 3, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06625775 live on ClinicalTrials.gov.

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