A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Metastatic Non-squamous NSCLC

ClinicalTrials.gov ID: NCT06627647

Public ClinicalTrials.gov record NCT06627647. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 6, 2026, 8:23 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase III, Randomized, Double-blind, Multicenter, Global Study of Rilvegostomig or Pembrolizumab in Combination With Platinum-based Chemotherapy for the First-line Treatment of Patients With Metastatic Non-squamous Non-small Cell Lung Cancer Whose Tumors Express PD-L1 (ARTEMIDE-Lung03)

Study identification

NCT ID: NCT06627647
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: AstraZeneca; Industry
Enrollment: 878 participants

Conditions and interventions

Conditions

Non-squamous Non-small Cell Lung Cancer

Interventions

Carboplatin Drug
Cisplatin Drug
Pembrolizumab Drug
Pemetrexed Drug
Rilvegostomig Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Nov 26, 2024
Primary completion: May 9, 2029
Completion: Mar 24, 2030
Last update posted: Mar 26, 2026

2024 – 2030

United States locations

U.S. sites: 77
U.S. states: 31
U.S. cities: 74

Facility	City	State	ZIP	Site status
Research Site	Mobile	Alabama	36608	Recruiting
Research Site	Chandler	Arizona	85224	Withdrawn
Research Site	Phoenix	Arizona	85054	Recruiting
Research Site	Anaheim	California	92801	Recruiting
Research Site	Beverly Hills	California	90211	Recruiting
Research Site	Loma Linda	California	92350	Not yet recruiting
Research Site	Redlands	California	92373	Recruiting
Research Site	San Diego	California	92123	Recruiting
Research Site	San Francisco	California	94121	Recruiting
Research Site	Santa Rosa	California	95403	Recruiting
Research Site	Walnut Creek	California	94598	Recruiting
Research Site	Lone Tree	Colorado	80124	Recruiting
Research Site	Stamford	Connecticut	06902	Recruiting
Research Site	West Haven	Connecticut	06516	Recruiting
Research Site	Newark	Delaware	19713	Recruiting
Research Site	Bay Pines	Florida	33744	Recruiting
Research Site	Fort Lauderdale	Florida	33308	Recruiting
Research Site	Gainesville	Florida	32610	Withdrawn
Research Site	Jacksonville	Florida	32224	Recruiting
Research Site	Miami	Florida	33125	Recruiting
Research Site	Ocala	Florida	34474	Not yet recruiting
Research Site	St. Petersburg	Florida	33709	Recruiting
Research Site	Atlanta	Georgia	30342	Withdrawn
Research Site	Boise	Idaho	83712	Recruiting
Research Site	Chicago	Illinois	60637	Recruiting
Research Site	Decatur	Illinois	62526	Recruiting
Research Site	Hinsdale	Illinois	60521	Recruiting
Research Site	Quincy	Illinois	62305	Recruiting
Research Site	Rockford	Illinois	61114	Withdrawn
Research Site	Waterloo	Iowa	50702	Recruiting
Research Site	Lexington	Kentucky	40509	Recruiting
Research Site	Lexington	Kentucky	40536	Withdrawn
Research Site	Louisville	Kentucky	40207	Recruiting
Research Site	Alexandria	Louisiana	71301	Withdrawn
Research Site	Baton Rouge	Louisiana	70808	Not yet recruiting
Research Site	Shreveport	Louisiana	71103	Recruiting
Research Site	Shreveport	Louisiana	71105	Recruiting
Research Site	South Portland	Maine	04106	Not yet recruiting
Research Site	Baltimore	Maryland	21202	Recruiting
Research Site	Grand Rapids	Michigan	49503	Recruiting
Research Site	Duluth	Minnesota	55805	Withdrawn
Research Site	Rochester	Minnesota	55905	Recruiting
Research Site	Saint Paul	Minnesota	55102	Recruiting
Research Site	Bridgeton	Missouri	63044	Recruiting
Research Site	Columbia	Missouri	65212	Withdrawn
Research Site	Lincoln	Nebraska	68506	Recruiting
Research Site	Camden	New Jersey	08103	Recruiting
Research Site	Buffalo	New York	14221	Recruiting
Research Site	Westbury	New York	11590	Recruiting
Research Site	Canton	Ohio	44710	Recruiting
Research Site	Medford	Oregon	97504	Recruiting
Research Site	Portland	Oregon	97239	Withdrawn
Research Site	Salem	Oregon	97301	Recruiting
Research Site	Pittsburgh	Pennsylvania	15212	Withdrawn
Research Site	York	Pennsylvania	17403	Recruiting
Research Site	Providence	Rhode Island	02903	Withdrawn
Research Site	Pierre	South Dakota	57501	Recruiting
Research Site	Sioux Falls	South Dakota	57105	Recruiting
Research Site	Chattanooga	Tennessee	37404	Recruiting
Research Site	Nashville	Tennessee	37203	Recruiting
Research Site	Fort Worth	Texas	76104	Recruiting
Research Site	Houston	Texas	77090	Withdrawn
Research Site	Irving	Texas	75063	Recruiting
Research Site	Kingwood	Texas	77339	Recruiting
Research Site	Lubbock	Texas	79410	Withdrawn
Research Site	Palestine	Texas	75801	Recruiting
Research Site	Round Rock	Texas	78665	Recruiting
Research Site	Fairfax	Virginia	22031	Recruiting
Research Site	Norfolk	Virginia	23502	Recruiting
Research Site	Roanoke	Virginia	24014	Recruiting
Research Site	Seattle	Washington	98101	Recruiting
Research Site	Seattle	Washington	98104	Withdrawn
Research Site	Silverdale	Washington	98383	Recruiting
Research Site	Spokane	Washington	99208	Recruiting
Research Site	Tacoma	Washington	98405	Recruiting
Research Site	Wenatchee	Washington	98801	Withdrawn
Research Site	La Crosse	Wisconsin	54601	Withdrawn

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 205 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06627647, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Mar 26, 2026 · Synced May 6, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06627647 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →