Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID

ClinicalTrials.gov ID: NCT06631287

Public ClinicalTrials.gov record NCT06631287. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 10, 2026, 6:09 AM EDT

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Official title

Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID (REVERSE-LC)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The overarching goal of this study is to determine if baricitinib, as compared to placebo, will improve neurocognitive function, along with measures of physical function, quality of life, post-exertional malaise, effect of breathlessness on daily activities, post-COVID-19 symptom burden, and biomarkers of inflammation and viral measures, in participants with Long COVID.

Study identification

NCT ID: NCT06631287
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Wes Ely; Other
Enrollment: 550 participants

Conditions and interventions

Conditions

Interventions

Baricitinib Drug
Placebo Other

Drug · Other

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Oct 20, 2024
Primary completion: Oct 31, 2026
Completion: Jun 30, 2027
Last update posted: May 10, 2026

2024 – 2027

United States locations

U.S. sites: 17
U.S. states: 15
U.S. cities: 16

Facility	City	State	ZIP	Site status
University of Arizona	Tucson	Arizona	85724	Recruiting
University of California, Los Angeles (UCLA)	Los Angeles	California	90024	Recruiting
University of California San Francisco	San Francisco	California	94143	Recruiting
University of Colorado I Anschutz Medical Campus	Aurora	Colorado	80045	Recruiting
Yale University	New Haven	Connecticut	06510	Recruiting
University of Florida College of Medicine	Gainesville	Florida	32610	Recruiting
Emory University	Atlanta	Georgia	30322	Recruiting
Illinois Research Network (ILLInet), University of Illinois Chicago	Chicago	Illinois	60608	Recruiting
Brigham and Women's Hospital	Boston	Massachusetts	02115	Recruiting
University of Minnesota	Minneapolis	Minnesota	55455	Recruiting
NYU Langone Health - Brooklyn	Brooklyn	New York	11220	Recruiting
University Hospitals Cleveland Case Western	Cleveland	Ohio	44106	Recruiting
The MetroHealth System	Cleveland	Ohio	44109	Recruiting
Vanderbilt University Medical	Nashville	Tennessee	37203	Recruiting
University of Texas at San Antonio	San Antonio	Texas	78229	Recruiting
Swedish Medical Center	Seattle	Washington	98104	Recruiting
West Virginia Clinical and Translational Science Institute	Morgantown	West Virginia	26506-7015	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06631287, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 10, 2026 · Synced Sep 10, 2026

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The complete protocol, eligibility criteria, and contact information for NCT06631287 live on ClinicalTrials.gov.

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